Association between interleukin-6 gene polymorphisms and rheumatoid arthritis in Chinese Han population: a case-control study and a meta-analysis
Open accessAbstract
The aim of this study was to investigate the possible association in the interleukin-6 (IL-6) gene with Rheumatoid arthritis (RA) in Chinese Han population from Shandong Province. Target regions of IL-6 gene were amplified by polymerase chain reaction (PCR) and genotyped. A logistic regression analysis was performed to detect potential associations in our case-control sample, the odd ratio(OR) and 95% confidence intervals(CIs) were calculated. Furthermore, we systematically tracked all the published studies in the field and performed a meta-analysis for the single nucleotide polymorphisms (SNPs) under study. 256 RA patients and 331 healthy controls were recruited into the case-control study. We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively). Significant difference was observed in haplotype frequencies of GCCGCT between RA patients and controls (P = 0.0001, OR = 4.066, 95%CI = 1.891 ~ 8.746), while GGCGCT frequencies was found lower in RA than controls (P = 0.006, OR = 0.669, 95%CI = 0.501 ~ 0.894). The results of the meta-analysis showed association polymorphism within the IL-6 promoter with RA. These findings suggest that rare IL-6 gene polymorphisms may associate with RA susceptibility in Han Chinese populations; however further studies are needed to assess the validity of the association of IL-6 with RA.
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GWAS, meta-analysis, exome analysis and SNP mapping have associated IL-6, IL-6R and gp130 with inflammatory diseases such as RA and coronary artery disease.
“Genome-wide association studies (GWAS), meta-analysis, exome analysis and single nucleotide polymorphism (SNP) mapping have associated IL-6, IL-6R and gp130 with inflammatory diseases such as RA and coronary artery disease (263–269).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [266]
The Abstract and Results (page numbers not provided) report a meta-analysis and case-control study associating IL-6 SNPs with rheumatoid arthritis. These passages do not support attributing associations involving IL-6R, gp130, or coronary artery disease—or findings from GWAS or exome analysis—to this paper. (LLM, conf=0.88)
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- Authors
- Li, F., Xu, J., Zheng, J., Sokolove, J., Zhu, K., Zhang, Y., Sun, H., Evangelou, E., & Pan, Z.
- Affiliations
- Shandong University (CN)
- Jinan City People's Hospital (CN)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Pan, Zhenglun
- Venue
- Scientific Reports
- Published
- 2014-07-17
- Volume
- 4
- Issue
- 1
- Pages
- 5714-5714
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4101469
- OpenAlex
- W1984763799
- Cited by
- 48
- References
- 18
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 11 · 2015: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Natural Science Foundation of China (30801025)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- interleukin-6, IL-6 gene polymorphism, rheumatoid arthritis, genetic susceptibility, single nucleotide polymorphisms, IL-6 promoter, haplotype association, rs1800795, rs1800797, Han Chinese
- MeSH terms
- Arthritis, Rheumatoid, China, Gene Frequency, Humans, Promoter Regions, Genetic, Interleukin-6, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies
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