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Immunomodulatory Effects of Curcumin
Abstract
Curcumin (diferuloylmethane), found in the spice turmeric, exhibits anti-inflammatory, antioxidant, and chemopreventive activities. However, the effect of curcumin on the immunological responses largely remains unknown. In this study we have investigated the effect of curcumin on mitogen (phytohaemagglutinin; PHA) stimulated T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCs), nitric oxide (NO) production in mouse macrophage cells, RAW-264.7. Furthermore, we have carried out an electromobility shift assay to elucidate the mechanism of action of curcumin at DNA protein interaction level. We observed that curcumin inhibits PHA-induced T-cell proliferation, interleukin-2 production, NO generation, and lipopolysachharide-induced nuclear factor-kappaB (NF-kappaB) and augments NK cell cytotoxicity. Our results suggest that curcumin most likely inhibits cell proliferation and cytokine production by inhibiting NF-kappaB target genes involved in the induction of these immune parameters.
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Citations
Cited by
CURCUMIN: THE INDIAN SOLID GOLD
Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,647
Carotenoids: biochemistry, pharmacology and treatment
Milani, A., Basirnejad, M., Shahbazi, S., & Bolhassani, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13625 · Cited by 781
Multiple molecular targets in cancer chemoprevention by curcumin
Thangapazham, R. L., Sharma, A., & Maheshwari, R. K. (2006) · The AAPS Journal · doi:10.1208/aapsj080352 · Cited by 310
Metadata
- Authors
- Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., & Singh, V. K.
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 27
- Issue
- 3
- Pages
- 485-497
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2170804837
- Cited by
- 215
- References
- 0
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., & Singh, V. K. (2005). Immunomodulatory Effects of Curcumin. Immunopharmacology and Immunotoxicology. https://doi.org/10.1080/08923970500242244
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