Carotenoids: biochemistry, pharmacology and treatment

Bioavailability of curcumin: Problems and promises

Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · see citing works

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638 · see citing works

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9432-8 · Cited by 2,124 · see citing works

Carotenoids and human health

RAO, A., & RAO, L. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.012 · Cited by 2,024 · see citing works

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works

Intake of Carotenoids and Retino in Relation to Risk of Prostate Cancer

Giovannucci, E. L., Ascherio, A., Rimm, E. B., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.23.1767 · Cited by 1,320 · see citing works

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Southan, C., Sharman, J., Benson, H., Faccenda, E., Pawson, A. J., Alexander, S. P. H., Buneman, O., Davenport, A., McGrath, J., Peters, J., et al. (2015) · Nucleic Acids Res. · doi:10.1093/nar/gkv1037 · Cited by 1,121 · see citing works

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

Wilken, R., Veena, M. S., Wang, M. B., & Srivatsan, E. S. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-12 · Cited by 1,072 · see citing works

Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration

Seddon, J. M. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520180037032 · Cited by 993 · see citing works

Bioactivity and protective effects of natural carotenoids

Stahl, W., & Sies, H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.12.006 · Cited by 898 · see citing works

Carotenoid Action on the Immune Response

Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795 · see citing works

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Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779 · see citing works

Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities

Saini, R. K., Nile, S. H., & Park, S. W. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.047 · Cited by 758 · see citing works

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

Kaulmann, A., & Bohn, T. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.010 · Cited by 675 · see citing works

The role of carotenoids in the prevention of human pathologies

Tapiero, H., Townsend, D. M., & Tew, K. D. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.12.006 · Cited by 647 · see citing works

Carotenoid radical chemistry and antioxidant/pro-oxidant properties

El-Agamey, A., Lowe, G. M., McGarvey, D. J., Mortensen, A., Phillip, D. M., Truscott, T. G., & Young, A. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.007 · Cited by 627 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13354 · Cited by 604 · see citing works

Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

Aggarwal, B. B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R. A., Bueso-Ramos, C., & Price, J. E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1192 · Cited by 583 · see citing works

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition &amp; Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569 · see citing works

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Ringman, J. M., Frautschy, S. A., Cole, G. M., Masterman, D. L., & Cummings, J. L. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585882 · Cited by 519 · see citing works

Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene

Levy, J., Bosin, E., Feldman, B., Giat, Y., Miinster, A., Danilenko, M., & Sharoni, Y. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514415 · Cited by 507 · see citing works

A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin

Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231204 · Cited by 482 · see citing works

Carotenoids and cardiovascular health

Voutilainen, S., Nurmi, T., Mursu, J., & Rissanen, T. H. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1265 · Cited by 463 · see citing works

Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in Cardiovascular Disease

Pashkow, F. J., Watumull, D. G., & Campbell, C. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.010 · Cited by 446 · see citing works

Lycopene and cardiovascular disease

Arab, L., & Steck, S. E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1691s · Cited by 438 · see citing works

Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice

De, R., Kundu, P., Swarnakar, S., et al. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01242-08 · Cited by 432 · see citing works

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

Nam, K. N., Park, Y.-M., Jung, H.-J., Lee, J. Y., Min, B. D., Park, S.-U., Jung, W., Cho, K., Park, J. H., Kang, I., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.003 · Cited by 431 · see citing works

Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy.

Kucuk, O., Sarkar, F. H., Sakr, W., Djurić, Z., Pollak, M., Khachik, F., Li, Y. W., Banerjee, M., Grignon, D. J., Bertram, J. S., et al. (2001) · PubMed · Cited by 416 · see citing works

MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation

Song, Y., Yue, Z.-Y., Wang, Z.-N., Xu, Y., Luo, Y., Xu, H., Zhang, X., Jiang, L., Xing, C., & Zhang, Y. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-1 · Cited by 392 · see citing works

Curcumin for malaria therapy

Reddy, R. C., Vatsala, P. G., Keshamouni, V. G., Padmanaban, G., & Rangarajan, P. N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.051 · Cited by 387 · see citing works

Curcumin Induces Apoptosis in Human Melanoma Cells through a Fas Receptor/Caspase-8 Pathway Independent of p53

Bush, J., Cheung, K. J., & Li, G. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5381 · Cited by 379 · see citing works

Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis

Dwyer, J. H., Navab, M., Dwyer, K. M., Hassan, K., Sun, P., Shircore, A. M., Hama-Levy, S., Hough, G., Wang, X., Drake, T. A., et al. (2001) · Circulation · doi:10.1161/01.cir.103.24.2922 · Cited by 338 · see citing works

Carotenoids: potential allies of cardiovascular health?

Gammone, M. A., Riccioni, G., & D’Orazio, N. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.26762 · Cited by 326 · see citing works

Crocus sativus L.: A comprehensive review

Srivastava, R., Ahmed, H., Dixit, R., Dharamveer, & Saraf, S. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.70919 · Cited by 325 · see citing works

Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention

Ribaya‐Mercado, J. D., & Blumberg, J. B. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719427 · Cited by 315 · see citing works

Tomatoes and risk of digestive‐tract cancers

Franceschi, S., Bidoli, E., Vecchia, C. L., Talamini, R., D’Avanzo, B., & Negri, E. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590207 · Cited by 312 · see citing works

Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial

Noorbala, A.-A., Akhondzadeh, S., Tahmacebi‐Pour, N., & Jamshidi, A. H. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.11.004 · Cited by 311 · see citing works

Curcumin Inhibits Immunostimulatory Function of Dendritic Cells: MAPKs and Translocation of NF-κB as Potential Targets

Kim, G., Kim, K., Lee, S.-H., Yoon, M., Lee, H.-J., Moon, D., Lee, C.-M., Ahn, S., Park, Y. C., & Park, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.8116 · Cited by 310 · see citing works

Antitumor Activity of β-Carotene, Canthaxanthin and Phytoene

Mathews‐Roth, M. M. (2009) · Oncology · doi:10.1159/000225601 · Cited by 309 · see citing works

Cis-Lycopene Is More Bioavailable Than Trans-Lycopene In Vitro and In Vivo in Lymph-Cannulated Ferrets

Boileau, A. C., Merchen, N. R., Wasson, K., Atkinson, C., & Erdman, J. W. (1999) · Journal of Nutrition · doi:10.1093/jn/129.6.1176 · Cited by 306 · see citing works

The protective role of curcumin in cardiovascular diseases

Wongcharoen, W., & Phrommintikul, A. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.01.073 · Cited by 293 · see citing works

Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care

Ciccone, M. M., Cortese, F., Gesualdo, M., Carbonara, S., Zito, A., Ricci, G., Pascalis, F. D., Scicchitano, P., & Riccioni, G. (2013) · Mediators of Inflammation · doi:10.1155/2013/782137 · Cited by 292 · see citing works

Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation

Kim, J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.81 · Cited by 285 · see citing works

Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement

Capelli, B., Bagchi, D., & Cysewski, G. R. (2013) · Nutrafoods · doi:10.1007/s13749-013-0051-5 · Cited by 278 · see citing works

Lutein and zeaxanthin in eye and skin health

Roberts, R. L., Green, J. A., & Lewis, B. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2008.01.011 · Cited by 276 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13355 · Cited by 267 · see citing works

Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS)

Moeller, S. M. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.8.1151 · Cited by 257 · see citing works

γ-Carotene, Carotenoids and the Prevention of Coronary Heart Disease

Kritchevsky, S. B. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.5 · Cited by 255 · see citing works

Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight Prospective Studies

Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. A., Gao, Y., Goodman, M. T., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs461 · Cited by 248 · see citing works

Effects of Turmeric ( Curcuma longa ) on Skin Health: A Systematic Review of the Clinical Evidence

Vaughn, A. R., Branum, A., & Sivamani, R. K. (2016) · Phytotherapy Research · doi:10.1002/ptr.5640 · Cited by 247 · see citing works

Health protective effects of carotenoids and their interactions with other biological antioxidants

Jomová, K., & Valko, M. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.09.054 · Cited by 244 · see citing works

Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo

Ochiai, T., Shimeno, H., Mishima, K.-I., et al. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.11.012 · Cited by 244 · see citing works

Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases—A Critical Review

Müller, L., Caris, C., Lowe, G., & Böhm, V. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.801827 · Cited by 238 · see citing works

Carotenoid Bioavailability in Humans from Tomatoes Processed in Different Ways Determined from the Carotenoid Response in the Triglyceride-Rich Lipoprotein Fraction of Plasma after a Single Consumption and in Plasma after Four Days of Consumption

Hof, K. H. V. H., de Boer, B. C. J., Tijburg, L. B. M., Lucius, B., Zijp, I. M., West, C. E., HAUTVAST, J. G. A. J., & Weststrate, J. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1189 · Cited by 237 · see citing works

Neuroprotection by crocetin in a hemi-parkinsonian rat model

Ahmad, A. S., Ansari, M. A., Ahmad, M., Saleem, S., Yousuf, S., Hoda, M. N., & Islam, F. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.007 · Cited by 237 · see citing works

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

Nahum, A., Hirsch, K., Danilenko, M., Watts, C. K. W., Prall, O. W. J., Levy, J., & Sharoni, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204452 · Cited by 236 · see citing works

Food carotenoids and cancer prevention: An overview of current research

Astorg, P. (1997) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(97)01092-3 · Cited by 234 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13347 · Cited by 230 · see citing works

Saffron and natural carotenoids: Biochemical activities and anti-tumor effects

Bolhassani, A., Khavari, A., & Bathaie, S. Z. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.11.001 · Cited by 228 · see citing works

Inhibition of homodimerization of Toll-like receptor 4 by curcumin

Youn, H. S., Saitoh, S. I., Miyake, K., & Hwang, D. H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.022 · Cited by 226 · see citing works

Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells.

Aung, H. H., Wang, C. Z., Ni, M., Fishbein, A. B., Mehendale, S. R., Xie, J., Shoyama, C. Y., & Yuan, C. (2007) · PubMed · Cited by 221 · see citing works

The effects of Crocus sativus (saffron) and its constituents on nervous system: A review.

Khazdair, M. R., Boskabady, M. H., Hosseini, M., Rezaee, R., & Tsatsakis, A. M. (2015) · Europe PMC (PubMed Central) · Cited by 218 · see citing works

Immunomodulatory and therapeutic activity of curcumin

Srivastava, R. M., Singh, S., Dubey, S. K., Misra, K., & Khar, A. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.014 · Cited by 216 · see citing works

Immunomodulatory Effects of Curcumin

Yadav, V. S., Mishra, K. P., Singh, D., et al. (2005) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970500242244 · Cited by 216 · see citing works

Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study

Rissanen, T. H., Voutilainen, S., Nyyssönen, K., Salonen, R., Kaplan, G. A., & Salonen, J. T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.133 · Cited by 206 · see citing works

Crocetin: an Agent Derived from Saffron for Prevention and Therapy for Cancer

Gutheil, W. G., Reed, G. A., Ray, A., et al. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112798868566 · Cited by 206 · see citing works

A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats

Moulton, C. J., Valentine, R. J., Layman, D. K., Devkota, S., Singletary, K. W., Wallig, M. A., & Donovan, S. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-1 · Cited by 201 · see citing works

Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma

Amin, A., Hamza, A. A., Bajbouj, K., et al. (2011) · Hepatology · doi:10.1002/hep.24433 · Cited by 200 · see citing works

Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro

Gao, X., Kuo, J., Jiang, H., Deeb, D., Liu, Y., Divine, G., Chapman, R., Dulchavsky, S. A., & Gautam, S. C. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.015 · Cited by 196 · see citing works

Inhibitory effect of dietary curcumin on skin carcinogenesis in mice

Limtrakul, P., Lipigorngoson, S., Namwong, O., et al. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)00187-0 · Cited by 195 · see citing works

Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines.

Gloria, N. F., Soares, N. D. C. P., Brand, C., de Oliveira, F. L., Borojević, R., & Teodoro, A. J. (2014) · PubMed · Cited by 194 · see citing works

Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma

LoTempio, M. M., Veena, M. S., Steele, H. L., Ramamurthy, B., Ramalingam, T. S., Cohen, A. N., Chakrabarti, R., Srivatsan, E. S., & Wang, M. B. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0301 · Cited by 194 · see citing works

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

Yasui, Y., Hosokawa, M., Mikami, N., Miyashita, K., & Tanaka, T. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.05.006 · Cited by 191 · see citing works

Chemotherapeutic Potential of Curcumin for Colorectal Cancer

Chauhan, D. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023394016 · Cited by 186 · see citing works

Immunomodulating actions of carotenoids: Enhancement of<i>in vivo</i>and<i>in vitro</i>antibody production to T‐dependent antigens

Jyonouchi, H., Zhang, L., Gross, M., & Tomita, Y. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514303 · Cited by 183 · see citing works

Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress

Kurihara, H., Kôda, H., Asami, S., Kiso, Y., & Tanaka, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01522-9 · Cited by 180 · see citing works

Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

Shen, G., Xu, C., Hu, R., Jain, M. R., Gopalkrishnan, A., Nair, S., Huang, M., Chan, J. Y., & Kong, A. T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0293 · Cited by 179 · see citing works

Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Wang, Y., Cui, R., Xiao, Y., Fang, J., & Xu, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137427 · Cited by 175 · see citing works

Lycopene Inhibits the Growth of Human Androgen-Independent Prostate Cancer Cells In Vitro and in BALB/c Nude Mice

Tang, L., Jin, T., Zeng, X., & Wang, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.287 · Cited by 173 · see citing works

Elaboration of microparticles of carotenoids from natural and synthetic sources for applications in food

Rutz, J. K., Borges, C. D., Zambiazi, R. C., et al. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.01.140 · Cited by 171 · see citing works

Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress

Schwedhelm, E., Maas, R., Troost, R., & ger, R. H. B. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00003 · Cited by 171 · see citing works

Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets.

Liu, C., Lian, F., Smith, D. E., Russell, R. M., & Wang, X. (2003) · PubMed · Cited by 170 · see citing works

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

Chadalapaka, G., Jutooru, I., Chintharlapalli, S. R., Papineni, S., Smith, R., Li, X., & Safe, S. H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6805 · Cited by 170 · see citing works

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

Alexander, S. P. H., Cidlowski, J. A., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13352 · Cited by 169 · see citing works

Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies

Aune, D., Chan, D. S. M., Vieira, A., Navarro-Rosenblatt, D., Vieira, R., Greenwood, D. C., & Norat, T. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034165 · Cited by 167 · see citing works

Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial

Talaeı, A., Moghadam, M. H., Tabassi, S. A. S., & Mohajeri, S. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.035 · Cited by 166 · see citing works

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity

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