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Phytoncides (Wood Essential Oils) Induce Human Natural Killer Cell Activity
Abstract
To explore the effect of forest bathing on the human immune system, we investigated the effect of phytoncides (wood essential oils) on natural killer (NK) activity and the expression of perforin, granzyme A and granulysin in human NK cells. We used NK-92MI cell, an interleukin-2 independent human NK cell line derived from the NK-92 cell, in the present study. NK-92MI cells express the CD56 surface marker, perforin, granzyme A, and granulysin by flow cytometry and are highly cytotoxic to K562 cells in chromium release assay. Phytoncides significantly increase cytolytic activity of NK-92MI cells in a dose-dependent manner and significantly increase the expression of perforin, granzyme A, and granulysin in the NK-92MI cells. Phytoncides also partially, but significantly, restore the decreased human NK activity and the decreased perforin, granzyme A, and granulysin expression in NK-92MI cells induced by dimethyl 2,2-dichlorovinyl phosphate (DDVP), an organophosphorus pesticide. Pretreatment with phytoncides partially prevents DDVP-induced inhibition of NK activity. Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin.
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Cited by
Nature Contact and Human Health: A Research Agenda
Frumkin, H., Bratman, G. N., Breslow, S. J., Cochran, B., Kahn Jr, P. H., Lawler, J. J., Levin, P. S., Tandon, P. S., Varanasi, U., Wolf, K. L., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1663 · Cited by 1,237
“…Brown et al. 2016; Thiering et al. 2016 16 Better eyesight French et al. 2013; Guggenheim et al. 2012; He et al. 2015 17 Improved immune function Li et al. 2006; Li et al. 2008a; Li et al. 2008b; Li et al. 2010; Li and Kawada 2011 18 Improved general health: Adults Brown et al. 2016; de Vries…”
BackgroundEffect of forest bathing trips on human immune function
Li, Q. (2010) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-008-0068-3 · Cited by 561
Self-citationAntonelli, M., Barbieri, G., & Donelli, D. (2019) · International Journal of Biometeorology · doi:10.1007/s00484-019-01717-x · Cited by 271
Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review
Antonelli, M., Donelli, D., Barbieri, G., Valussi, M., Maggini, V., & Firenzuoli, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186506 · Cited by 237
Medical empirical research on forest bathing (Shinrin-yoku): a systematic review
Wen, Y., Yan, Q., Pan, Y., Gu, X., & Liu, Y. (2019) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-019-0822-8 · Cited by 235
Metadata
- Authors
- Li, Q., Nakadai, A., Matsushima, H., Miyazaki, Y., Krensky, A. M., Kawada, T., & Morimoto, K.
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 28
- Issue
- 2
- Pages
- 319-333
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2158634318
- Cited by
- 194
- References
- 0
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Q., Nakadai, A., Matsushima, H., Miyazaki, Y., Krensky, A. M., Kawada, T., & Morimoto, K. (2006). Phytoncides (Wood Essential Oils) Induce Human Natural Killer Cell Activity. Immunopharmacology and Immunotoxicology. https://doi.org/10.1080/08923970600809439
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