The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Stress and Hypothermia in Mice in A Nose-Only Cigarette Smoke Exposure System
Abstract
In nose-only exposure systems, animals need to be restrained inside a tube, which leads to stress. Stress is known to cause hyperthermia in rodents. Chronically repeated episodes of hyperthermia could be detrimental to animal health and influence results of nose-only exposure studies. Therefore we investigated whether hyperthermia occurred in male C57BL/6J mice that were restrained for increasing lengths of time, using nosepieces held at room temperature, preheated at 37 degrees C, or thermostat controlled at different temperatures, with and without exposure to different concentrations of cigarette smoke. Body temperature, body weight, plasma corticosterone levels, and adrenal weights were recorded. Restraint using nosepieces at room temperature caused a time-dependent decrease in body temperature, which could be reversed by preheating the nosepieces to 37 degrees C. Cigarette smoke dose-dependently caused an additional decrease, which was counteracted by controlling nosepiece temperature at 38 degrees C. During 3 mo of exposure using heated nosepieces, Delta body temperature remained constant. Body weight gain did not differ between smoke-exposed and room air-breathing animals exposed using either heated or room-temperature nosepieces, but both groups gained significantly less weight, while adrenal weights were significantly and similarly increased, when compared to unrestrained littermates. Plasma corticosterone levels did not differ between the three groups. In conclusion,…
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“Both inhalation methods have pitfalls. In one hand, a precise analysis of the aerosol can be made following exposure in chamber, but the amount of inhaled fibers is less precise (hair deposition, etc.); on the other hand, animals housed in a container represent a different situation from the human working activities, and some studies suggest that animals can be stressed in these conditions [50-55]”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [55]
Citations
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Cited by
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Metadata
- Authors
- van Eijl, S., van Oorschot, R., Olivier, B., Nijkamp, F. P., & Bloksma, N.
- Venue
- Inhalation Toxicology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 18
- Issue
- 11
- Pages
- 911-918
- ISSN
- 0895-8378
- 1091-7691
- Cited by
- 33
- References
- 23
- Language
- en
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