The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Impact of nose-only exposure system on pulmonary gene expression
Abstract
Nose-only exposure is used to study the distribution and toxicity of airborne contaminants. Restraint of animals in nose-only tubes causes stress, but the impact on pulmonary mRNA levels is unknown. Since stress and xenobiotics activate common pathways, we assessed whether nose-only exposure would alter expression of toxicologically relevant genes in the lungs. To identify candidate genes for further analysis, we first interrogated microarray data to examine time-dependent changes in gene expression in air-control animals from a nose-only inhalation study involving male wild-type C57BL/6 mice and transgenic tumor necrosis factor (TNF)-alpha over-expressing littermates. Comparison of transcript levels immediately and 24 h after a single 4-h nose-only exposure to air revealed differential expression of 280 genes (false discovery rate-adjusted, p < .05). Functional analysis revealed enrichment of immune response, apoptosis, and signalling terms, consistent with effects of restraint stress. We then selected a subset of target genes for comparison of naive animals and air-exposed animals from the inhalation study by real-time polymerase chain reaction (PCR). Expression of genes involved in stress (BNIP, sestrin-1, CDKN1A [p21], GADD45 gamma), glucocorticoid-response (GILZ, Sgk), and signal transduction (MAP3K6, C/EBP-delta) was increased as a result of nose-only exposure (p < .05). In contrast, proinflammatory factors (lymphotoxin-beta, chemokine receptor CXCR5) were decreased (p…
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“Both inhalation methods have pitfalls. In one hand, a precise analysis of the aerosol can be made following exposure in chamber, but the amount of inhaled fibers is less precise (hair deposition, etc.); on the other hand, animals housed in a container represent a different situation from the human working activities, and some studies suggest that animals can be stressed in these conditions [50-55]”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [53]
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Cited by
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry
Oberdörster, G., Castranova, V., Asgharian, B., & Sayre, P. (2015) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2015.1051611 · Cited by 150
Metadata
- Authors
- Thomson, E. M., Williams, A., Yauk, C. L., & Vincent, R.
- Venue
- Inhalation Toxicology
- Publisher
- Informa UK Limited
- Published
- 2009-06-30
- Volume
- 21
- Issue
- sup1
- Pages
- 74-82
- ISSN
- 0895-8378
- 1091-7691
- Cited by
- 15
- References
- 38
- Language
- en
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- Thomson, E. M., Williams, A., Yauk, C. L., & Vincent, R. (2009). Impact of nose-only exposure system on pulmonary gene expression. Inhalation Toxicology. https://doi.org/10.1080/08958370902962309
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
