Stress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
Abstract
A bstract : Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)‐12, tumor necrosis factor (TNF)‐α, and interferon (IFN)‐γ, whereas they stimulate the production of antiinflammatory cytokines, such as IL‐10, IL‐4, and transforming growth factor (TGF)‐β. Thus, systemically, an excessive immune response, through activation of the stress system, stimulates an important negative feedback mechanism, which protects the organism from an “overshoot” of proinflammatory cytokines and other products of activated macrophages with tissue‐damaging potential. Conversely, in certain local responses and under certain conditions, stress hormones actually may boost regional immune responses, through induction of TNF‐α, IL‐1, and IL‐8, and by inhibiting TGF‐β production. Therefore, conditions that are associated with significant changes in stress system activity, such as acute or chronic stress, cessation of chronic stress, severe exercise, and pregnancy and the postpartum period, through modulation of the systemic or local pro/antiinflammatory cytokine balance, may suppress or potentiate autoimmune diseases activity and/or progression.
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Noradrenaline is a part of the human stress response and has been suggested to potentiate cytokine production.
“Noradrenaline is a part of the human stress response and has been suggested to potentiate cytokine production.45”
From Association of depressive disorders, depression characteristics and antidepressant medication with inflammation (2012) · cites this paper as [45]
Cites
The expanding universe of T-cell subsets: Th1, Th2 and more
Mosmann, T. R., & Sad, S. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80606-2 · Cited by 3,603 · see citing works
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works
Self-citationTrinchieri, G. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001343 · Cited by 2,427 · see citing works
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252 · see citing works
Self-citationThe Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,718 · see citing works
Rate of Pregnancy-Related Relapse in Multiple Sclerosis
Confavreux, C., Hutchinson, M., Hours, M. M., Cortinovis-Tourniaire, P., & Moreau, T. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390501 · Cited by 1,559 · see citing works
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519 · see citing works
Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance
Beutler, B., Krochin, N., Milsark, I. W., Luedke, C. E., & Cerami, A. (1986) · Science · doi:10.1126/science.3754653 · Cited by 1,268 · see citing works
Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes
Lotz, M., Vaughan, J. H., & Carson, D. A. (1988) · Science · doi:10.1126/science.2457950 · Cited by 925 · see citing works
Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease
Elenkov, I. J., & Chrousos, G. P. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00188-5 · Cited by 804 · see citing works
Self-citationGlucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates
Boumpas, D. T., Chrousos, G. P., Wilder, R. L., Cupps, T. R., & Balow, J. E. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-12-199312150-00007 · Cited by 765 · see citing works
Self-citationMarzi, M., Viganò, M., Trabattoni, D., Villa, M. L., SALVAGGIO, A., Clerici, E., & Clerici, M. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-809.x · Cited by 613 · see citing works
An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease
Segal, B., Dwyer, B. K., & Shevach, E. (1998) · Journal of Experimental Medicine · doi:10.1084/jem.187.4.537 · Cited by 534 · see citing works
Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
Ramírez, F., Fowell, D. J., Puklavec, M. J., Simmonds, S. J., & Mason, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2406 · Cited by 483 · see citing works
Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
Karalis, K. P., Sano, H., Redwine, J. M., LISTWAK, S. J., Wilder, R. L., & Chrousos, G. P. (1991) · Science · doi:10.1126/science.1925600 · Cited by 482 · see citing works
Self-citationBeta2-agonists prevent Th1 development by selective inhibition of interleukin 12.
Panina‐Bordignon, P., Mazzeo, D., Lucia, P. D., D’Ambrosio, D., Lang, R., Fabbri, L. M., Self, C., & Sinigaglia, F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119674 · Cited by 461 · see citing works
Neuroendocrine-Immune System Interactions and Autoimmunity
Wilder, R. L. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001515 · Cited by 457 · see citing works
Theoharides, T. C., Singh, L. K., Boucher, W. S., Pang, X., Létourneau, R., Webster, E., & Chrousos, G. P. (1998) · Endocrinology · doi:10.1210/endo.139.1.5660 · Cited by 447 · see citing works
Self-citationWoiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schöning, B., Glöckner, F., Lanksch, W., Volk, H., & Döcke, W. (1998) · Nature Medicine · doi:10.1038/nm0798-808 · Cited by 435 · see citing works
Sanders, V. M., Baker, R. A., Ramer-Quinn, D. S., Kasprowicz, D. J., Fuchs, B. A., & Street, N. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4200 · Cited by 434 · see citing works
Elenkov, I. J., Papanicolaou, D. A., Wilder, R. L., & Chrousos, G. P. (1996) · PubMed · Cited by 419 · see citing works
Self-citationFrequency of lupus flare in pregnancy: The hopkins lupus pregnancy center experience
Petri, M., Howard, D., & Repke, J. T. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780341210 · Cited by 392 · see citing works
Spengler, R. N., Allen, R., Remick, D. G., Strieter, R. M., & Kunkel, S. L. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.5.1430 · Cited by 388 · see citing works
Blotta, M. H. S. L., DeKruyff, R. H., & Umetsu, D. T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5589 · Cited by 352 · see citing works
Miller, L. E., Jüsten, H., Schcölmerich, J., & Straub, R. H. (2000) · The FASEB Journal · doi:10.1096/fj.99-1082com · Cited by 294 · see citing works
Elenkov, I. J., Wilder, R. L., Bakalov, V. K., Link, A. A., Dimitrov, M. A., Fisher, S., Crane, M., Kanik, K. S., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7905 · Cited by 272 · see citing works
Self-citationDeKruyff, R. H., Fang, Y., & Umetsu, D. T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2231 · Cited by 241 · see citing works
Theoharides, T. C., Spanos, C., Pang, X., Alferes, L., Ligris, K., Letourneau, R., Rozniecki, J. J., Webster, E., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588332 · Cited by 214 · see citing works
Lombardi, M. S., Kavelaars, A., Schedlowski, M., Bijlsma, J. W. J., Okihara, K. L., van de Pol, M., Ochsmann, S., Pawlak, C. R., Schmidt, R. E., & Heijnen, C. J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.715 · Cited by 208 · see citing works
Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness
Wu, C. Y., Wang, K., McDyer, J. F., & Seder, R. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2723 · Cited by 207 · see citing works
Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: What is the evidence?
Brandt, K. D., Smith, G. N., & Simon, L. S. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200006)43:6 · Cited by 204 · see citing works
Tulzo, Y. L., Shenkar, R., Kaneko, D., Moine, P., Fantuzzi, G., Dinarello, C. A., & Abraham, E. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119314 · Cited by 187 · see citing works
Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men
Tabardel, Y., Duchateau, J., Schmartz, D., Marécaux, G., Shahla, M., Barvais, L., LeClerc, J.-L., & Vincent, J. (1996) · Surgery · doi:10.1016/s0039-6060(96)80217-0 · Cited by 179 · see citing works
Elenkov, I. J., Haskó, G., Kovács, K., & Vizi, E. S. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00080-l · Cited by 178 · see citing works
Self-citationSubstance P-induced IL-12 production by murine macrophages
Kincy-Cain, T., & Bost, K. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2334 · Cited by 161 · see citing works
Substance P and Calcitonin Gene-Related Peptide: Effects on Mast Cells and in Human Skin
Foreman, J. C. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234229 · Cited by 160 · see citing works
The effects of pregnancy on autoimmune diseases
Buyon, J. P. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.3.281 · Cited by 139 · see citing works
SYSTEMIC LUPUS ERYTHEMATOSUS FLARES DURING PREGNANCY
Khamashta, M. A., Ruiz‐Irastorza, G., & Hughes, G. R. V. (1997) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70312-4 · Cited by 130 · see citing works
van der Poll, T., Barber, A. E., Coyle, S. M., & Lowry, S. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855809 · Cited by 129 · see citing works
HOPKINS LUPUS PREGNANCY CENTER: 1987 TO 1996
Petri, M. (1997) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70311-2 · Cited by 127 · see citing works
Interaction of Neuropeptides with Human Mast Cells
Church, M. K., Lowman, M. A., Robinson, C., Holgate, S. T., & Benyon, C. R. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234752 · Cited by 127 · see citing works
Singh, V. K., & Leu, S.-J. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90025-5 · Cited by 123 · see citing works
β2-Adrenergic activation enhances interleukin-8 production by human monocytes
Kavelaars, A., van de Pol, M., Zijlstra, J., & Heijnen, C. J. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00076-3 · Cited by 123 · see citing works
Borger, P., Hoekstra, Y., Esselink, M. T., Postma, D. S., Zaagsma, J., Vellenga, E., & Kauffman, H. F. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.3.2765 · Cited by 113 · see citing works
Greig, P. C., Herbert, W. N. P., Robinette, B. L., & Teot, L. A. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91358-0 · Cited by 113 · see citing works
Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse
Gayo, A., Mozo, L., Suárez, A., Tuñon, A., Lahoz, C., & Gutiérrez, C. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00262-2 · Cited by 107 · see citing works
Irwin, M. R. (1994) · Advances in Neuroimmunology · doi:10.1016/s0960-5428(06)80188-9 · Cited by 106 · see citing works
Malfait, A., Malik, A. S., Marinova-Mutafchieva, L., Butler, D., Maini, R. N., & Feldmann, M. (1999) · PubMed · Cited by 96 · see citing works
Wiegmann, K., Muthyala, S., Kim, D. H., Arnason, B. G. W., & Chelmicka-Schorr, E. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)00153-f · Cited by 95 · see citing works
Haskó, G., Elenkov, I. J., Kvetan, V., & Vizi, E. S. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1440457 · Cited by 95 · see citing works
Self-citationHaskó, G., Szabó, C., Nemeth, Z. H., Salzman, A. L., & Vizi, E. S. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00073-3 · Cited by 95 · see citing works
Malfait, A., Malik, A. S., Marinova-Mutafchieva, L., Butler, D. M., Maini, R. N., & Feldmann, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.6278 · Cited by 92 · see citing works
Stimulation of interleukin-6 production by corticotropin-releasing factor
Leu, S.-J. C., & Singh, V. K. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90018-k · Cited by 90 · see citing works
Felten, D. L., Felten, S. Y., Bellinger, D. L., & Lorton, D. (1992) · PubMed · Cited by 90 · see citing works
Karaszewski, J. W., Reder, A. T., Maselli, R. A., Brown, M., & Arnason, B. G. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270404 · Cited by 84 · see citing works
Chelmicka‐Schorr, E., Kwasniewski, M. N., Thomas, B., & Arnason, B. G. W. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90138-0 · Cited by 84 · see citing works
Cadet, P., Rady, P. L., Tyring, S. K., Yandell, R. B., & Hughes, T. K. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90164-7 · Cited by 83 · see citing works
Elenkov, I. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.10.4933 · Cited by 80 · see citing works
Self-citationElenkov, L. J., Hoffman, J., & Wilder, R. L. (1997) · Molecular Medicine Today · doi:10.1016/s1357-4310(97)01089-7 · Cited by 72 · see citing works
MacKenzie, F. J., Leonard, J. P., & Cuzner, M. L. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90027-1 · Cited by 68 · see citing works
Wilder, R. L., & Elenkov, I. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07619.x · Cited by 68 · see citing works
Self-citationHellstrand, K., & Hermodsson, S. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234972 · Cited by 58 · see citing works
Lindén, A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16000.x · Cited by 58 · see citing works
Effects of Stress on Alveolar Macrophages: A Role for the Sympathetic Nervous System
Broug-Holub, E., Persoons, J. H. A., Schornagel, K., Mastbergen, S. C., & Kraal, G. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.5.3103 · Cited by 58 · see citing works
The Effects of Pregnancy on Autoimmune Diseases
Buyon, J. P., Nelson, J. L., & Lockshin, M. D. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0018 · Cited by 58 · see citing works
Kovács, K., & Elenkovt, I. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00662.x · Cited by 58 · see citing works
Batuman, O., Ferrero, A., Cupp, C., Jiménez, S. A., & Khalili, K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4397 · Cited by 56 · see citing works
Karaszewski, J. W., Reder, A. T., Anlar, B., & Arnason, B. G. W. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90068-a · Cited by 54 · see citing works
Dose- and time-dependent activation of rat alveolar macrophages by glucocorticoids
Broug-Holub, E., & Kraal, G. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.29733.x · Cited by 52 · see citing works
Diminished autonomic nervous system responsiveness in rheumatoid arthritis of recent onset.
Geenen, R., Godaert, G. L. R., Jacobs, J. W. G., Peters, M. L., & Bijlsma, J. W. J. (1996) · PubMed · Cited by 51 · see citing works
Lorton, D., Bellinger, D. L., Duclos, M., Felten, S. Y., & Felten, D. L. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00150-6 · Cited by 49 · see citing works
Ho, W., Stavropoulos, G., Lai, J.-P., Hu, B., Magafa, V., Anagnostides, S. T., & Douglas, S. D. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00175-6 · Cited by 37 · see citing works
Blood Lymphocyte β‐Adrenergic Receptors in Multiple Sclerosis
Arnason, B. G. W., BROWN, M., Maselli, R. A., KARASZEWSKI, J., & Reder, A. T. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb27181.x · Cited by 30 · see citing works
Baker, A., & Fuller, R. W. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.3.395 · Cited by 24 · see citing works
Immunoregulation in Rapidly Progressive Multiple Sclerosisa
Arnason, B. G. W., Noronha, A., & Reder, A. T. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb27046.x · Cited by 19 · see citing works
Straub, R. H., & Cutolo, M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200103)44:3
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1 of the 77 references couldn’t be matched to a known paper.
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Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd, P. M. (2003) · PubMed · Cited by 1,102 · see citing works
How stress influences the immune response
Padgett, D. A., & Glaser, R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00173-x · Cited by 1,059 · see citing works
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968 · see citing works
Therapeutic strategies for rheumatoid arthritis
Smolen, J. S., & Steiner, G. E. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1109 · Cited by 915 · see citing works
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
Cumulative childhood stress and autoimmune diseases in adults
Dube, S. R., Fairweather, D., Pearson, W. S., Felitti, V. J., Anda, R. F., & Croft, J. B. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907888 · Cited by 820 · see citing works
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works
Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749 · see citing works
Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies
BOSCARINO, J. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.011 · Cited by 691 · see citing works
Glucocorticoids and the Th1/Th2 Balance
Elenkov, I. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.010 · Cited by 607 · see citing works
Self-citationNeurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580 · see citing works
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541 · see citing works
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Self-citationPsychologic intervention improves survival for breast cancer patients
Andersen, B. L., Yang, H., Farrar, W. B., Golden‐Kreutz, D. M., Emery, C. F., Thornton, L. M., Young, D. C., & Carson, W. E. (2008) · Cancer · doi:10.1002/cncr.23969 · Cited by 495 · see citing works
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The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
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Ambros‐Rudolph, C. M., Müllegger, R., Jones, S. V., Kerl, H., & Black, M. M. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.12.012 · Cited by 419 · see citing works
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The impact of psychosocial stress and stress management on immune responses in patients with cancer
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Varnum, M. M., & Ikezu, T. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0181-2 · Cited by 395 · see citing works
Psychosocial Aspects of Chronic Disease: ESRD as a Paradigmatic Illness
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Self-citationAnesthetics, immune cells, and immune responses
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Gerritsen, R. J. S., & Band, G. P. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00397 · Cited by 342 · see citing works
Schneider, T., Roman, A., Basta‐Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., & Przewłocki, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.011 · Cited by 338 · see citing works
Sadowsky, D. W., Waldorf, K. M. A., Gravett, M. G., Witkin, S. S., & Novy, M. J. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.072 · Cited by 332 · see citing works
Vogelzangs, N., Duivis, H. E., Beekman, A. T. F., Kluft, C., Neuteboom, J., Hoogendijk, W., Smit, J. H., de Jonge, P., & Penninx, B. W. J. H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.8 · Cited by 323 · see citing works
“45 Use of SNRI, TCA and TeCA has also been observed to disturb functioning of autonomic nervous sys-tem, 46 blood pressure 47 and the metabolic syndrome.”
BackgroundduPont, N. C., Wang, K., Wadhwa, P. D., Culhane, J. F., & Nelson, E. L. (2005) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2005.03.005 · Cited by 319 · see citing works
Landi, S., Moreno, V. R., Gioia‐Patricola, L., Guinó, E., Navarro, M., de, J., Capellá, G., & Canzian, F. (2003) · PubMed · Cited by 315 · see citing works
The environment and autoimmune thyroid diseases
Prummel, M. F., Strieder, T. G. A., & Wiersinga, W. M. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500605 · Cited by 298 · see citing works
You, Z., Luo, C., Zhang, W., Chen, Y., He, J., Zhao, Q., Zuo, R. M., & Wu, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.006 · Cited by 301 · see citing works
FROHLICH, M. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00260-4 · Cited by 294 · see citing works
Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms
García‐Bueno, B., Caso, J. R., & Leza, J. C. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.001 · Cited by 280 · see citing works
Yang, I. H., Corwin, E. J., Brennan, P. A., Jordan, S., Murphy, J. R., & Dunlop, A. L. (2015) · Nursing Research · doi:10.1097/nnr.0000000000000133 · Cited by 283 · see citing works
Elenkov, I. J. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.037 · Cited by 273 · see citing works
Self-citationStress System – Organization, Physiology and Immunoregulation
Elenkov, I. J., & Chrousos, G. P. (2006) · NeuroImmunoModulation · doi:10.1159/000104853 · Cited by 267 · see citing works
Self-citationPsychosocial Factors and Inflammation in the Multi-Ethnic Study of Atherosclerosis
Ranjit, N. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.2.174 · Cited by 261 · see citing works
Stress, Endocrine Physiology and Pathophysiology -- Endotext
DeGroot, L. J., Chrousos, G. P., Dungan, K., Grossman, A. B., Jm, H., Koch, C., Korbonits, M., McLachlan, R., New, M., Purnell, J. Q., et al. (2000) · Europe PMC (PubMed Central) · Cited by 260 · see citing works
Self-citationMaking sense of apparently conflicting data: Stress and immunity in swine and cattle1
Salak‐Johnson, J. L., & McGlone, J. J. (2007) · Journal of Animal Science · doi:10.2527/jas.2006-538 · Cited by 255 · see citing works
Prenatal Stress Alters Cytokine Levels in a Manner That May Endanger Human Pregnancy
Coussons‐Read, M. E., Okun, M. L., Schmitt, M. P., & Giese, S. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170331.74960.ad · Cited by 247 · see citing works
Neeman, E., & Ben‐Eliyahu, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.006 · Cited by 245 · see citing works
Glasner, A., Avraham, R., Rosenne, E., Benish, M., Zmora, O., Shemer, S., Meiboom, H., & Ben‐Eliyahu, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903301 · Cited by 239 · see citing works
Tian, R., Hou, G., Li, D., & Yuan, T. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/780616 · Cited by 237 · see citing works
Influence of Stress and Nutrition on Cattle Immunity
Carroll, J. A., & Forsberg, N. E. (2007) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2007.01.003 · Cited by 337 · see citing works
Immune Influence on Adult Neural Stem Cell Regulation and Function
Carpentier, P. A., & Palmer, T. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.038 · Cited by 235 · see citing works
Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
Grippo, A. J., Francis, J., Beltz, T. G., Felder, R. B., & Johnson, A. K. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.011 · Cited by 233 · see citing works
Raiten, D. J., Ashour, F. A. S., Ross, A. C., Meydani, S. N., Dawson, H. D., Stephensen, C. B., Brabin, B. J., Suchdev, P. S., & van Ommen, B. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.194571 · Cited by 234 · see citing works
Diz-Chaves, Y., Pernía, O., Carrero, P., & García‐Segura, L. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-71 · Cited by 232 · see citing works
Heckenberg, R. A., Eddy, P. J., Kent, S., & Wright, B. J. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.09.010 · Cited by 233 · see citing works
A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects
Coghlan, M. J., Jacobson, P. B., Lane, B. C., Nakane, M., Lin, C. W., Elmore, S. W., Kym, P. R., Luly, J. R., Carter, G. W., Turner, R. T., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0355 · Cited by 224 · see citing works
Stout, R. D., & Suttles, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00260.x · Cited by 220 · see citing works
Achiron, A., Kishner, I., Dolev, M., Stern, Y., Dulitzky, M., Schiff, E., & Achiron, R. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0495-z · Cited by 215 · see citing works
Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects
Razavi Nematollahi, L., Kitabchi, A. E., Stentz, F. B., Wan, J. Y., Larijani, B. A., Tehrani, M. M., Gozashti, M. H., Omidfar, K., & Taheri, E. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.018 · Cited by 210 · see citing works
Quinteiro-Filho, W. M., Rodrigues, M. V., Ribeiro, A. B., Ferraz-de-Paula, V., Pinheiro, M. L., de Sá, L. R. M., Ferreira, A. J. P., & Palermo‐Neto, J. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-3949 · Cited by 218 · see citing works
Depressive disorders—is it time to endorse different pathophysiologies?
Antonijevic, I. A. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.004 · Cited by 207 · see citing works
Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate
El-Shenawy, N. S. (2009) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2009.06.001 · Cited by 207 · see citing works
Molecular links between endocrine, nervous and immune system during chronic stress
Zefferino, R., Di Gioia, S., & Conese, M. (2021) · Brain and Behavior · doi:10.1002/brb3.1960 · Cited by 204 · see citing works
Cytokine secretion in macrophages and other cells: Pathways and mediators
Stow, J. L., Low, P. C., Offenhäuser, C., & Sangermani, D. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.005 · Cited by 205 · see citing works
Sympathetic Hyperactivity in Chronic Renal Failure
Koomans, H. A., Blankestijn, P. J., & Joles, J. A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000113320.57127.b9 · Cited by 203 · see citing works
The effects of shift work on physical and mental health
Vogel, M., Braungardt, T., Meyer, W. T., & Schneider, W. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0800-4 · Cited by 198 · see citing works
Probing the Effects of Stress Mediators on the Human Hair Follicle
Peters, E. M. J., Liotiri, S., Bodó, E., Hagen, E., Bı́ró, T., Arck, P., & Paus, R. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061206 · Cited by 196 · see citing works
Genetic variation associated with preterm birth: a HuGE review
Crider, K. S., Whitehead, N., & Buus, R. M. (2005) · Genetics in Medicine · doi:10.1097/01.gim.0000187223.69947.db · Cited by 190 · see citing works
Wang, L., Wang, R., Liu, L., Qiao, D., Baldwin, D. S., & Hou, R. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.021 · Cited by 186 · see citing works
Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage
Wang, Y., & Sun, Z. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134320 · Cited by 183 · see citing works
Antioxidant and Anti-Inflammatory Activities of the PlantAndrographis PaniculataNees
Sheeja, K., Kochumon, S., & Kuttan, G. (2006) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970600626007 · Cited by 179 · see citing works
Effect of propofol and isoflurane anaesthesia on the immune response to surgery*
Inada, T., Yamanouchi, Y., Jomura, S., Sakamoto, S., Takahashi, M., Kambara, T., & Shingu, K. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2004.03837.x · Cited by 178 · see citing works
McElwee, K. J., Gilhar, A., Tobin, D. J., Ramot, Y., Sundberg, J. P., Nakamura, M., Bertolini, M., Inui, S., TOKURA, Y., King, L. E., et al. (2013) · Experimental Dermatology · doi:10.1111/exd.12209 · Cited by 177 · see citing works
Alkhalifah, A. (2012) · Dermatologic Clinics · doi:10.1016/j.det.2012.08.010 · Cited by 176 · see citing works
Anti-inflammatory properties of anesthetic agents
Cruz, F. F., Rocco, P. R. M., & Pelosi, P. P. (2017) · Critical Care · doi:10.1186/s13054-017-1645-x · Cited by 171 · see citing works
Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173 · see citing works
How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis
Straub, R. H., Dhabhar, F. S., Bijlsma, J. W. J., & Cutolo, M. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20747 · Cited by 168 · see citing works
Zaldivar, F. P., Wang‐Rodriguez, J., Nemet, D., Schwindt, C. D., Galassetti, P. R., Mills, P. J., Wilson, L. D., & Cooper, D. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00562.2005 · Cited by 167 · see citing works
Marc, D. T., Ailts, J. W., Campeau, D. A., Bull, M. J., & Olson, K. L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.007 · Cited by 164 · see citing works
Heat Shock Protein 10 Inhibits Lipopolysaccharide-induced Inflammatory Mediator Production
Johnson, B. J. B., Le, T. T., Dobbin, C. A., Banovic, T., Howard, C. B., Flores, F. D. M. L., Vanags, D. M., Naylor, D. J., Hill, G. R., & Suhrbier, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411569200 · Cited by 165 · see citing works
Alopecia areata: pathogenesis and potential for therapy
Lu, W. D., Shapiro, J., Yu, M., Barekatain, A., Lo, B. K. K., Finner, A. M., & McElwee, K. J. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940601101x · Cited by 164 · see citing works
Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
Gray, S. M., & Bloch, M. H. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0272-0 · Cited by 162 · see citing works
The Impact of Everyday Stressors on the Immune System and Health
Seiler, A., Fagundes, C. P., & Christian, L. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16996-1_6 · Cited by 169 · see citing works
Gomez, D. I., Corréa, P., Gómez, L. M., Cadena, J., Molina, J. F., & Anaya, J. (2004) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2003.11.002 · Cited by 161 · see citing works
Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma
Lutgendorf, S. K., Lamkin, D. M., Jennings, N. B., Arevalo, J. M. G., Penedo, F., DeGeest, K., Langley, R. R., Lucci, J. A., Cole, S. W., Lubaroff, D. M., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0230 · Cited by 158 · see citing works
Koelsch, S., Boehlig, A., Hohenadel, M. G., Nitsche, I., Bauer, K., & Sack, U. (2016) · Scientific Reports · doi:10.1038/srep23008 · Cited by 162 · see citing works
Carta, M. G., Loviselli, A., Hardoy, M. C., Massa, S., Cadeddu, M., Sardu, C., Carpiniello, B., Dell’Osso, L., & Mariotti, S. (2004) · BMC Psychiatry · doi:10.1186/1471-244x-4-25 · Cited by 159 · see citing works
Interleukin 1 Polymorphisms and Intervertebral Disc Degeneration
Solovieva, S. A., Kouhia, S., Leino‐Arjas, P., Ala‐Kokko, L., Luoma, K., Raininko, R., Saarela, J., & Riihimäki, H. (2004) · Epidemiology · doi:10.1097/01.ede.0000135179.04563.35 · Cited by 153 · see citing works
Leiro, J. M., Arranz, J. A., Yáñez, M., Ubeira, F. M., Sanmartín, M. L., & Orallo, F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.03.002 · Cited by 152 · see citing works
Cardiac Mast Cells Mediate Left Ventricular Fibrosis in the Hypertensive Rat Heart
Levick, S. P., McLarty, J. L., Murray, D. B., Freeman, R. M., Carver, W. E., & Brower, G. L. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.123158 · Cited by 152 · see citing works
Possible association of interleukin 1 gene locus polymorphisms with low back pain
Solovieva, S. A., Leino‐Arjas, P., Saarela, J., Luoma, K., Raininko, R., & Riihimäki, H. (2004) · Pain · doi:10.1016/j.pain.2003.10.020 · Cited by 149 · see citing works
Siegle, G. J., Moore, P. M., & Thase, M. E. (2004) · Cognitive Therapy and Research · doi:10.1023/b:cotr.0000045570.62733.9f · Cited by 148 · see citing works
Staats, P. S., Hekmat, H. M., Sauter, P. K., & Lillemoe, K. D. (2001) · Pain Medicine · doi:10.1046/j.1526-4637.2001.002001028.x · Cited by 147 · see citing works
Shift of Monocyte Function Toward Cellular Immunity During Sleep
Lange, T. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1695 · Cited by 145 · see citing works
Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147 · see citing works
Chronopharmacology of glucocorticoids
Scherholz, M. L., Schlesinger, N., & Androulakis, I. P. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.004 · Cited by 145 · see citing works
Biomarkers of Psychological Stress in Health Disparities Research
Djurić, Z., Bird, C. E., Furumoto-Dawson, A., Rauscher, G. H., Ruffin, M. T., Stowe, R. P., Tucker, K. L., & Masi, C. M. (2008) · The Open Biomarkers Journal · doi:10.2174/1875318300801010007 · Cited by 145 · see citing works
Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models
Marco, E. M., Macrì, S., & Laviola, G. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9205-z · Cited by 144 · see citing works
Düzgüner, V., & Erdoğan, S. (2009) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2009.11.008 · Cited by 144 · see citing works
Psychological Stress Exerts an Adjuvant Effect on Skin Dendritic Cell Functions In Vivo
Saint-Mézard, P., Chavagnac, C., Bosset, S., Ionescu, M., Peyron, E., Kaiserlian, D., Nicolas, J., & Bérard, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4073 · Cited by 140 · see citing works
Exercise and Brain Health ??? Implications for Multiple Sclerosis
White, L. J., & Castellano, V. (2008) · Sports Medicine · doi:10.2165/00007256-200838020-00001 · Cited by 138 · see citing works
Hostility and pain are related to inflammation in older adults
Graham‐Engeland, J. E., Robles, T. F., Kiecolt‐Glaser, J. K., Malarkey, W. B., Bissell, M. G., & Glaser, R. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.11.002 · Cited by 139 · see citing works
Marsland, A. L., Prather, A. A., Petersen, K. L., Cohen, S., & Manuck, S. B. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.11.008 · Cited by 138 · see citing works
- Authors
- ELENKOV, I. J., & CHROUSOS, G. P.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- ELENKOV, ILIA J.
- ORCID
- CHROUSOS, GEORGE P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2002-06
- Volume
- 966
- Issue
- 1
- Pages
- 290-303
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1987912134
- Cited by
- 983
- References
- 77
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 32 · 2023: 29 · 2022: 32 · 2021: 39 · 2020: 35 · 2019: 52 · 2018: 33 · 2017: 34 · 2016: 42 · 2015: 51 · 2014: 43 · 2013: 46 · 2012: 52
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- stress hormones, glucocorticoids, catecholamines, inflammatory cytokines, autoimmunity, autoimmune disease, IL-12, TNF-α, interferon-gamma, IL-10, TGF-beta, negative feedback regulation, chronic stress, physical activity, pregnancy, postpartum period
- MeSH terms
- Animals, Autoimmune Diseases, Catecholamines, Feedback, Female, Gene Expression Regulation, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Macrophage Activation, Male, Pregnancy, Pregnancy Complications, Puerperal Disorders, Rats, Inbred Lew, Stress, Physiological, Sympathetic Nervous System, Neuroimmunomodulation, Autoimmunity, Cytokines, Antigen Presentation, Th1 Cells, Th2 Cells, Models, Immunological, Inflammation Mediators, Rats
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