Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 11

The DOI matches its Crossref record.

Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1

Kawanobe, Takaaki, Shiranaga, Naoko, Kioka, Noriyuki, Kimura, Yasuhisa, Ueda, Kazumitsu·2019·Bioscience, Biotechnology, and Biochemistry
DOI 10.1080/09168451.2018.1547106
Open this paper in CoChat — free account

Abstract

ATP-binding cassette transporter A1 (ABCA1) is critical for the generation of nascent high-density lipoprotein (HDL) and plays important roles in cholesterol homeostasis. ABCA1 has two large extracellular domains (ECDs), which may interact directly with apolipoprotein A-I (apoA-I). However, the molecular mechanisms underlying HDL formation and the importance of ABCA1–apoA-I interactions in HDL formation remain unclear. We investigated the ABCA1–apoA-I interaction in photo-activated crosslinking experiments using sulfo-SBED–labeled apoA-I. ApoA-I bound to cells expressing ABCA1, but not to untransfected cells or cells expressing non-functional ABCA1. Binding was inhibited by sulfo-SBED–labeled apoA-I, and crosslinking of sulfo-SBED–labeled apoA-I with ABCA1 was inhibited by non-labeled apoA-I, suggesting that sulfo-SBED–labeled apoA-I specifically binds and crosslinks with functional ABCA1. Proteolytic digestion of crosslinked ABCA1 revealed that apoA-I bound the N-terminal half of ABCA1, and that the first ECD of ABCA1 is an apoA-I binding site. Abbreviations: ABC: ATP-binding cassette; apoA-I: apolipoprotein A-I; ATP: adenosine triphosphate; CHAPS: 3-(3-cholamidepropyl)dimethylammonio-1- propanesulphonate; DTT: dithiothreitol; ECD: extra cellular domain; EDTA: ethylenediaminetetraacetic acid; GFP: green fluorescent protein; HA: hemagglutinin; HDL: high density lipoprotein; HEK: human embryonic kidney; HEPES: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; sulfo-SBED: (sulfosuccinimidyl-2-[6-(biotinamido)-2-(p-azidobenzamido)hexanoamido] ethyl-1,3ʹ-dithiopropionate; NHS-ester, N-hydroxysuccinimide-ester

Overview

Integrity signals

Registry

Crossref · 10.1080/09168451.2018.1547106

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 26

  1. Khera, 2011, Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis, N Engl J Med, 364, 127, 10.1056/NEJMoa1001689 · DOI · Paper page
  2. Segrest, 1999, A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein, J Biol Chem, 274, 31755, 10.1074/jbc.274.45.31755 · DOI
  3. Li, 2006, Structural analysis of nanoscale self-assembled discoidal lipid bilayers by solid-state NMR spectroscopy, Biophys J, 91, 3819, 10.1529/biophysj.106.087072 · DOI
  4. Wu, 2007, The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction, Nat Struct Mol Biol, 14, 861, 10.1038/nsmb1284 · DOI
  5. Bodzioch, 1999, The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease, Nat Genet, 22, 347, 10.1038/11914 · DOI · Paper page
  6. Brooks-Wilson, 1999, Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency, Nat Genet, 22, 336, 10.1038/11905 · DOI · Paper page
  7. Rust, 1999, Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1, Nat Genet, 22, 352, 10.1038/11921 · DOI · Paper page
  8. Oram, 2006, ATP-Binding cassette cholesterol transporters and cardiovascular disease, Circ Res, 99, 1031, 10.1161/01.RES.0000250171.54048.5c · DOI · Paper page
  9. Hozoji, 2009, Formation of two intramolecular disulfide bonds is necessary for apoA-I-dependent cholesterol efflux mediated by ABCA1, J Biol Chem, 284, 11293, 10.1074/jbc.M900580200 · DOI
  10. Ishigami, 2018, Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation, Sci Rep, 8, 6170, 10.1038/s41598-018-24428-6 · DOI
  11. Fitzgerald, 2002, Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I, J Biol Chem, 277, 33178, 10.1074/jbc.M204996200 · DOI
  12. Fitzgerald, 2004, ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux, J Lipid Res, 45, 287, 10.1194/jlr.M300355-JLR200 · DOI
  13. Chroni, 2004, Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1, Biochemistry, 43, 2126, 10.1021/bi035813p · DOI
  14. Vedhachalam, 2007, ABCA1-induced cell surface binding sites for apoA-I, Arterioscler Thromb Vasc Biol, 27, 1603, 10.1161/ATVBAHA.107.145789 · DOI
  15. Nagao, 2012, ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding, J Lipid Res, 53, 126, 10.1194/jlr.M019976 · DOI
  16. Phillips, 2014, Molecular mechanisms of cellular cholesterol efflux, J Biol Chem, 289, 24020, 10.1074/jbc.R114.583658 · DOI
  17. Tanaka, 2001, Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren’s syndrome, Biochem Biophys Res Commun, 283, 1019, 10.1006/bbrc.2001.4891 · DOI
  18. Ritchie, 2009, Chapter 11 Reconstitution of membrane proteins in phospholipid bilayer nanodiscs, Methods Enzymol, 464, 211, 10.1016/S0076-6879(09)64011-8 · DOI
  19. Deffieu, 2011, Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding, Proc Natl Acad Sci U S A, 108, 18932, 10.1073/pnas.1110439108 · DOI
  20. Amundson, 1999, Fluorometric method for the enzymatic determination of cholesterol, J. Biochem. Biophys. Methods, 38, 43, 10.1016/S0165-022X(98)00036-0 · DOI
  21. Hirayama, 2013, ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin, J Lipid Res, 54, 496, 10.1194/jlr.M033209 · DOI
  22. Nakanishi, 2011, Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase, Biochim Biophys Acta, 1807, 1170, 10.1016/j.bbabio.2011.05.012 · DOI
  23. Favari, 2009, Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1, Biochemistry, 48, 11067, 10.1021/bi901564g · DOI · Paper page
  24. Nagao, 2009, Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation, J Lipid Res, 50, 1165, 10.1194/jlr.M800597-JLR200 · DOI
  25. Qian, 2017, Structure of the human lipid exporter ABCA1, Cell, 169, 1228, 10.1016/j.cell.2017.05.020 · DOI
  26. Vedhachalam, 2007, Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles, J Biol Chem, 282, 25123, 10.1074/jbc.M704590200 · DOI

Cited by

Metadata

Authors
Kawanobe, T., Shiranaga, N., Kioka, N., Kimura, Y., & Ueda, K.
Affiliations
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Venue
Bioscience, Biotechnology, and Biochemistry
Publisher
Informa UK Limited
Published
2019-03-04
Volume
83
Issue
3
Pages
490-497
ISSN
  • 0916-8451
  • 1347-6947
DOI
10.1080/09168451.2018.1547106
Cited by
11
References
0
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • AMED-PRIME (JP18gm5910022)
  • Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (15H01638, 15K07390, 18H05269, 18K19176)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.