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Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

Favari, Elda, Calabresi, Laura, Adorni, Maria Pia, Jessup, Wendy, Simonelli, Sara, Franceschini, Guido, Bernini, Franco·2009·Biochemistry
DOI 10.1021/bi901564g
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Abstract

The aim of this study was to correlate the lipid content and size of discoidal reconstituted HDL particles with their ability to promote cellular cholesterol efflux. Homogeneous discoidal rHDL particles containing apoA-I and POPC, with diameters of 7.8, 9.6, 10.8, 12.5, and 17.0 nm, were prepared by the cholate dialysis technique. Cholesterol efflux to rHDL was evaluated in pathway-specific cell models for ABCA1-, ABCG1-, and SR-BI-mediated efflux. ABCA1-mediated efflux was efficiently promoted by the 7.8 nm rHDL containing 82 POPC molecules per particle. This rHDL also promoted ABCG1, but not SR-BI, cholesterol efflux. All large and lipid-rich rHDLs, with a diameter of >or=9.6 nm and a phospholipid content of >/=202 molecules per particle, promoted both SR-BI- and ABCG1-mediated efflux. Our results indicated that the ABCA1-mediated cell cholesterol efflux can be efficiently driven not only by monomolecular lipid free/poor apoA-I but also by a small discoidal phospholipid-containing particle resembling plasma pre-beta1 HDL. This same particle also promotes ABCG1- but not SR-BI-mediated efflux. These results help to clarify the role of plasma pre-beta1 HDL in reverse cholesterol transport.

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Metadata

Authors
Favari, E., Calabresi, L., Adorni, M. P., Jessup, W., Simonelli, S., Franceschini, G., & Bernini, F.
Affiliations
  • Department of Pharmacological and Biological Sciences, and Applied Chemistries, University of Parma, Parma, Italy
  • Center E. Grossi Paoletti, Department of Pharmacological Sciences, Università degli Studi di Milano, Milano, Italy
  • Centre for Vascular Research, University of New South Wales, Sydney, Australia
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
2009-10-29
Volume
48
Issue
46
Pages
11067-11074
ISSN
  • 0006-2960
  • 1520-4995
DOI
10.1021/bi901564g
Cited by
123
References
0
Language
en

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