Influence of the type of pegylated interferon on the onset of depressive and neuropsychiatric symptoms in HIV-HCV coinfected patients
Abstract
This is a prospective observational comparative 48-week study to assess the impact of the different types of Peg-IFN on depressive and neuropsychiatric symptoms during treatment in HIV-HCV coinfected patients. Thirty-one patients treated with Peg-IFN alpha-2b 1.5 microg/kg/w plus ribavirine (RBV) (Peg-IFN alpha-2b Group) and 32 patients receiving Peg-IFN alpha-2a 180 microg/w plus RBV (Peg-IFN alpha-2a Group) were included. Depressive and neuropsychiatric symptoms, quality of life and adherence were assessed. Fifteen subjects (23%) discontinued therapy (p = 0.3, between groups). Overall, 37 patients presented mild to moderate depressive symptoms, 9 moderate to severe and 3 severe, without differences between groups. Patients in Peg-IFN alpha-2b reported higher fatigue and dizziness at weeks 12 (p < 0.05) and 24 (p < 0.05), and irritability and memory loss at week 24 (p < 0.05) with respect to Peg-IFN alpha-2a Group. At week 12, role functioning, general health perception, vitality, emotional role, mental health and the summary areas of physical health and mental health were lower in Peg-IFN alpha-2b Group (p < 0.05). The same was observed in physical functioning (p = 0.05) and role functioning, general health perception, emotional role and mental health (p < 0.001) at week 24. Three months after finishing treatment, no patient had depressive or neuropsychiatric symptoms, and quality of life improved. Antiretroviral adherence was low but adherence to anti-HCV therapy remained high in both groups. According to our data, Peg-IFN alpha-2a and Peg-IFN alpha-2b exert a similar impact on the overall rate of depressive symptoms, although patients treated with Peg-IFN alpha-2a experience less fatigue and fewer neuropsychiatric symptoms and a lower impairment in their physical and mental quality of life.
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Confidence in one's ability to pursue goals affects how well people adhere to medication across many long-term illnesses.
“Self-efficacy or confidence in one’s ability to successfully engage in goal-directed behavior has been shown to influence medication adherence across many chronic illnesses.”
From Reliability and validity of a self‐efficacy instrument for hepatitis C antiviral treatment regimens (2012) · cites this paper as [16]
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- Authors
- Fumaz, C. R., Muñoz-Moreno, J. A., Ballesteros, A. L., Paredes, R., Ferrer, M. J., Salas, A., Fuster, D., Masmitjà, E., Pérez-Álvarez, N., Gómez, G., Tural, C., & Clotet, B.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- a Lluita contra la SIDA Foundation , Barcelona , Spain
- Hospital Universitari Germans Trias i Pujol (ES)
- Fundació Lluita contra les Infeccions (ES)
- d Universitat Politècnica de Catalunya , Barcelona , Spain
- IrsiCaixa (ES)
- Corresponding author
- Fumaz, C. R.
- Venue
- AIDS Care
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 19
- Issue
- 1
- Pages
- 138-145
- ISSN
- 0954-0121 (ISSN-L)
- 1360-0451
- OpenAlex
- W2021182443
- Cited by
- 30
- References
- 35
- Citations by year
- 2019: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2013: 5 · 2012: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- Fundación Para La Innovación Y La Prospectiva En Salud En España
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- pegylated interferon, HIV/HCV coinfection, depressive symptoms, neuropsychiatric symptoms, antiviral therapy, quality of life, fatigue, medication adherence, antiretroviral therapy
- MeSH terms
- Interferon alpha-2, Adult, Antidepressive Agents, Antiviral Agents, Mental Disorders, Drug Therapy, Combination, Female, Humans, Male, Polyethylene Glycols, Prospective Studies, Quality of Life, Recombinant Proteins, Recurrence, Ribavirin, HIV Infections, Treatment Refusal, Interferon-alpha, Hepatitis C, Chronic
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