The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Depression in multiple sclerosis
Abstract
Depressive disorders occur in up to 50% of people living with multiple sclerosis (MS). Prevalence estimates are generally 2-3-times higher than those of the general population. Myriad aetiologic factors may contribute to the aetiology of depression in MS including biological mechanisms (e.g. hippocampal microglial activation, lesion burden, regional atrophy), as well as the stressors, threats, and losses that accompany living with an unpredictable and often disabling disease. Some prominent risk factors for depression such as (younger) age, (female) sex, and family history of depression are less consistently associated with depression in MS than they are in the general population. Management of depression in MS has not been well studied, but available data on detection and treatment align with general principles of depression management. While the validity of standard measurement scales has often been questioned, available evidence suggests that standard scales provide valid ratings. Evidence for the effectiveness of depression treatments in MS is limited, but available evidence supports the effectiveness of standard treatment approaches, including both cognitive behavioural therapies and antidepressant medications.
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“patients with autoimmune diseases with elevated TH17 cells often exhibit comorbid depression (Kurd et al., 2010; Patten et al., 2017).”
From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Patten et al., 2017
Citations
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Cited by
Sorted by citations
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136
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Metadata
- Authors
- Patten, S. B., Marrie, R. A., & Carta, M. G.
- Affiliations
- University of Calgary (CA)
- University of Manitoba (CA)
- University of Cagliari (IT)
- Corresponding author
- Patten, Scott B.
- Venue
- International Review of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2017-07-06
- Volume
- 29
- Issue
- 5
- Pages
- 463-472
- ISSN
- 0954-0261 (ISSN-L)
- 1369-1627
- OpenAlex
- W2726625509
- Cited by
- 262
- References
- 103
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 34 · 2023: 33 · 2022: 43 · 2021: 34 · 2020: 57 · 2019: 11 · 2018: 7 · 2017: 2
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, multiple sclerosis, prevalence, etiology, lesion burden, brain atrophy, stressors, risk factors, depression screening, depression treatment, cognitive behavioral therapy, antidepressants, measurement scales
- MeSH terms
- Adult, Antidepressive Agents, Depression, Female, Humans, Male, Multiple Sclerosis, Brief Psychiatric Rating Scale, Cognitive Behavioral Therapy, Prevalence
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