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Cited by 11Traumatic Brain Injury ResearchSleep and related disordersTraumatic Brain Injury and Neurovascular Disturbances

Gender role in sleep disturbances among older adults with traumatic brain injury

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Ledger, Conor, Karameh, Wael K., Munoz, David G., Fischer, Corinne E., Schweizer, Tom A.·2020·International Review of Psychiatry
DOI 10.1080/09540261.2019.1657384PMC PMC7255060
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Abstract

Older adults are particularly vulnerable to poor long-term outcomes, and the rate of TBI in this group is increasing. Studies have shown females experience worse outcomes from TBI than males, however this research has been limited. The aim of this study is to examine gender effects on the frequency of sleep disturbances in older adults post-TBI. An analysis was conducted on data obtained from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. A total of 405 patients greater than 60 years of age were examined. Sleep disturbances were measured using the Nighttime Behavioural Disturbances domain of the Neuropsychiatric Inventory–Questionnaire (NPI-Q). A significant difference (p = 0.025) in reported sleep disturbance was identified in the female TBI population relative to the female non-TBI population. In the male non-TBI group, 14.8% (n = 12) experienced nighttime disturbances while 19.8% (n = 17) of those with TBI experienced nighttime disturbances. This difference was not significant (p = 0.305). These results suggest there is a greater impact from traumatic brain injury on sleep disturbances in older females than males. Further research examining gender differences in older adults related to neuropsychiatric outcomes of TBI should be considered given the implications for treatment.

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  • With regards to sleep after TBI, women often report having worse sleep outcomes after injury than men, and the female sex is considered to be a risk factor when measuring sleep disorders after injury.

    “With regards to sleep after TBI, women often report having worse sleep outcomes after injury than men, and the female sex is considered to be a risk factor when measuring sleep disorders after injury.103–107”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [105]

    The Discussion reports a greater increase in sleep disturbances after TBI among older women (12.1%) than older men (5.0%), and the Conclusion says TBI has a greater impact on sleep disturbances in older women. The claim extends this finding beyond older adults and describes it as a risk factor for sleep disorders, whereas this study measured reported sleep disturbances. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 20

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Authors
Ledger, C., Karameh, W. K., Munoz, D. G., Fischer, C. E., & Schweizer, T. A.
Affiliations
  • St. Michael's Hospital (CA)
  • Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada;
Corresponding author
Fischer, Corinne E.
ORCID
Venue
International Review of Psychiatry
Publisher
Informa UK Limited
Published
2019-09-23
Volume
32
Issue
1
Pages
39-45
ISSN
  • 0954-0261 (ISSN-L)
  • 1369-1627
DOI
10.1080/09540261.2019.1657384
PMC
PMC7255060
OpenAlex
W2975302602
Cited by
11
References
1
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 2
FWCI
0.76
Type
journal article
Language
en
Open access
Locations
  • International Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (P30AG053760, P30AG010129, P30AG010133, P30AG049638, P30AG028383, P30AG012300, P50AG005133, U01AG016976, P50AG005131, P50AG005138, P30AG010124, P50AG016573, P50AG047366, P30AG008017, P30AG010161, P30AG008051, P50AG008702, P50AG033514, P30AG035982, P50AG005681, P50AG005142, P50AG047270, P30AG019610, P50AG005146, P30AG013846, P50AG005136, P50AG005134, P30AG013854, P50AG025688, P50AG047266, P30AG066444, U24AG072122, P50AG023501, P50AG016574)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
traumatic brain injury, sleep disorders, older adults, gender differences, sex differences, neuropsychiatric symptoms, long-term outcomes
MeSH terms
Brain Injuries, Traumatic, Aged, Aged, 80 and over, Aging, Female, Humans, Male, Sex Factors, Sleep Wake Disorders

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