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Cited by 285Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix®) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study

Freeman, M, Vinciullo, C, Francis, D, Spelman, L, Nguyen, R, Fergin, P, Thai, K‐E, Murrell, D, Weightman, W, Anderson, C, Reid, C, Watson, A, Foley, P·2003·Journal of Dermatological Treatment
DOI 10.1080/09546630310012118
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Abstract

BACKGROUND: Actinic keratosis (AK) is a very common condition, which has the potential of progressing to squamous cell carcinoma. The present study is a prospective, randomized study comparing the lesion response, cosmetic outcome, patient satisfaction and tolerability of a new treatment modality, photodynamic therapy (PDT), using topical methyl aminolevulinate (Metvix), with the most commonly used standard therapy for AK, cryotherapy. METHODS: A total of 204 patients with clinically diagnosed AK were randomized to either cryotherapy or PDT. The PDT patients were further assigned to an active or placebo group in a random, double-blind manner. Cryotherapy was performed using liquid nitrogen spray in a single freeze-thaw cycle. PDT was performed using 160 mg/g methyl aminolevulinate cream or placebo, a 3-hour application time, red light (570-670 nm) and a total light dose of 75 J/cm(2). PDT was repeated after 7 days. Two sessions of PDT were undertaken, as a previous study had shown a single session had similar efficacy to cryotherapy. Lesion response was assessed clinically after 3 months (complete response or non-complete response). RESULTS: The lesion response rate was 91% in the methyl aminolevulinate PDT group, 68% in the cryotherapy group and 30% in the placebo PDT group. Methyl aminolevulinate PDT was statistically significantly better than both cryotherapy and placebo PDT in terms of response rates and cosmetic outcome. Most patients preferred PDT to other treatments. CONCLUSIONS: PDT with methyl aminolevulinate is an excellent treatment option, particularly for patients with widespread damage or AK lesions in cosmetically sensitive areas.

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Crossref · 10.1080/09546630310012118

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Research works printed but not linked: 3

  1. Szeimies RM, 1996, Pharmacology and Treatment, 192, 246
  2. Fritsch C, 1998, Photo- chem Photobiol, 68, 218
  3. 10.1067/mjd.2002.119649 · DOI

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Metadata

Authors
Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Nguyen, R., Fergin, P., Thai, K., Murrell, D., Weightman, W., Anderson, C., Reid, C., Watson, A., & Foley, P.
Affiliations
  • The Skin Centre, Gold Coast, QLD
  • The Perth Surgicentre, Perth, WA
  • The Belmont Specialist Clinic, Brisbane, QLD
  • Skin and Cancer Foundation (AU)
  • St George Hospital (AU)
  • Queen Elizabeth Hospital (AU)
  • Liverpool Hospital (AU)
  • Royal Adelaide Hospital (AU)
  • Royal Newcastle Hospital, Newcastle, NSW
  • St Vincent's Hospital Melbourne (AU)
Corresponding author
Foley, P
ORCID
Venue
Journal of Dermatological Treatment
Publisher
Informa UK Limited
Published
2003-01-01
Volume
14
Issue
2
Pages
99-106
ISSN
  • 0954-6634 (ISSN-L)
  • 1471-1753
DOI
10.1080/09546630310012118
OpenAlex
W2007413267
Cited by
285
References
21
Citations by year
2026: 5 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 10 · 2014: 19 · 2013: 5 · 2012: 15
FWCI
13.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dermatological Treatment (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
actinic keratosis, photodynamic therapy, methyl aminolevulinate, cryotherapy, liquid nitrogen spray, cosmetic outcome, patient satisfaction, treatment tolerability, squamous cell carcinoma prevention
MeSH terms
Administration, Cutaneous, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Cryosurgery, Double-Blind Method, Female, Humans, Keratosis, Male, Middle Aged, Photochemotherapy, Prospective Studies, Severity of Illness Index, Victoria, Treatment Outcome, Photosensitizing Agents

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