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Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions: II. Chinese Hamster V79 Cells
Abstract
Inactivation and mutation to thioguanine-resistance of V79 hamster cells were studied after irradiation with accelerated helium, boron or nitrogen ions covering a range of linear energy transfer from 28 to 470 keV micrometers-1. For all radiation qualities a dose-dependent increase in mutant frequency was found for doses giving surviving fractions greater than about 0.20. The effectiveness per unit dose for both inactivation and mutation induction increased with the linear energy transfer of the radiation to a maximum in the range 90-200 keV micrometer-1. However, the maximum mutagenic effectiveness relative to gamma-rays was about two or more times that for inactivation. It is suggested that a proportion of the radiation-induced mutants suffer extensive genetic damage, and that some forms of this damage may be induced with high efficiency by radiations of high linear energy transfer.
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Cited by
Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058651 · Cited by 552
Friedland, W., Dingfelder, M., Kundrát, P., & Jacob, P. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.01.003 · Cited by 386
Space Radiation Cancer Risks and Uncertainties for Mars Missions
Cucinotta, F. A., Schimmerling, W., Wilson, J. W., Peterson, L. E., Badhwar, G. D., Saganti, P. B., & Dicello, J. F. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0682:srcrau]2.0.co;2 · Cited by 328
Effects of Radiations of Different Qualities on Cells: Molecular Mechanisms of Damage and Repair
Goodhead, D. T., Thacker, J., & Cox, R. (1993) · International Journal of Radiation Biology · doi:10.1080/09553009314450721 · Cited by 292
Self-citationFriedrich, T., Scholz, U., ElsaSser, T., Durante, M., & Scholz, M. (2013) · Journal of Radiation Research · doi:10.1093/jrr/rrs114 · Cited by 287
Metadata
- Authors
- Thacker, J., Stretch, A., & Stephens, M. A.
- Venue
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Publisher
- Informa UK Limited
- Published
- 1979-01
- Volume
- 36
- Issue
- 2
- Pages
- 137-148
- ISSN
- 0020-7616 (ISSN-L)
- OpenAlex
- W1843977103
- Cited by
- 251
- References
- 0
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions: II. Chinese Hamster V79 Cells. https://app.cochat.ai/papers/10.1080/09553007914550891
- The paper
- Thacker, J., Stretch, A., & Stephens, M. A. (1979). Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions: II. Chinese Hamster V79 Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. https://doi.org/10.1080/09553007914550891
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
