MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy
Open accessAbstract
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry.
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Beta- and gamma-radiation are viewed as having a relative biologic efficiency of 1.0, while emerging radiopharmaceutical therapies using alpha-particle emitters carry a much higher relative biologic efficiency.
“Although b - and g -radiation are viewed as having a relative biologic ef fi ciency (RBE) of 1.0, other emerging RPTs, particularly those that use radionuclides that emit a -particles, carry much a higher RBE ( 21 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [21]
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Cites
THE STOPPING AND RANGE OF IONS IN SOLIDS
Ziegler, J. F. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-780621-1.50005-8 · Cited by 9,056 · see citing works
THE STOPPING AND RANGE OF IONS IN SOLIDS
Ziegler, J. F. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-780620-4.50007-0 · Cited by 5,869 · see citing works
Recommendations of the International Commission on Radiological Protection
(1961) · Postgraduate Medical Journal · doi:10.1136/pgmj.37.425.168-b · Cited by 5,868 · see citing works
The Stopping and Range of Ions in Matter
Ziegler, J. F., & Biersack, J. P. (1985) · Springer eBooks · doi:10.1007/978-1-4615-8103-1_3 · Cited by 4,009 · see citing works
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498 · see citing works
The Stopping and Ranges of Ions in Matter
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-02882-4 · Cited by 2,982 · see citing works
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228 · see citing works
International Commission on Radiological Protection
(1969) · Radiology · doi:10.1148/93.6.1298 · Cited by 2,153 · see citing works
Basic anatomical and physiological data for use in radiological protection: reference values
Valentin, J. (2002) · Annals of the ICRP · doi:10.1016/s0146-6453(03)00002-2 · Cited by 2,024 · see citing works
Report of the task group on reference man
(1979) · Annals of the ICRP · doi:10.1016/0146-6453(79)90123-4 · Cited by 1,715 · see citing works
(1995) · Annals of the ICRP · doi:10.1016/s0146-6453(00)80008-1 · Cited by 1,369 · see citing works
Benefits and costs, an eternal balance
Dixon, A. K. (2007) · Annals of the ICRP · doi:10.1016/j.icrp.2007.09.001 · Cited by 1,355 · see citing works
Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229 · see citing works
Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA
Goodhead, D. T. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550021 · Cited by 1,204 · see citing works
Firestone, R. B., & Browne, E. (1998) · Elsevier eBooks · doi:10.1016/b978-0-12-436255-0.50019-8 · Cited by 1,078 · see citing works
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
Nagasawa, H., & Little, J. B. (1992) · PubMed · Cited by 1,003 · see citing works
Bolch, W. E., Eckerman, K. F., Sgouros, G., & Thomas, S. R. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.056036 · Cited by 913 · see citing works
Self-citationTHE INTERNATIONAL COMMISSION ON RADIATION UNITS AND MEASUREMENTS
Wambersie, A. (2004) · Journal of the ICRU · doi:10.1093/jicru/ndh019 · Cited by 869 · see citing works
Recommendations of the International Commission on Radiological Protection Publication 60
Icrp (1991) · Medical Entomology and Zoology · Cited by 833 · see citing works
Jain, R. K., & Baxter, L. T. (1988) · PubMed · Cited by 710 · see citing works
Ws, S., Hl, F., Mr, F., & Warner, G. G. (1969) · PubMed · Cited by 627 · see citing works
Comments on ICRU Report No. 49: Stopping Powers and Ranges for Protons and Alpha Particles
Ziegler, J. F. (1999) · Radiation Research · doi:10.2307/3580097 · Cited by 619 · see citing works
National Technical Information Service
Holcombe, S. L. (2008) · Reference Reviews · doi:10.1108/09504120810872238 · Cited by 611 · see citing works
1990 Recommendations of the International Commission on Radiological Protection.
(1991) · PubMed · Cited by 600 · see citing works
Azzam, E. I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011417098 · Cited by 594 · see citing works
Siegel, J. A., Thomas, S. R., Stubbs, J. B., Mg, S., Hays, M. T., Koral, K. F., Robertson, J. S., Howell, R. W., Wessels, B. W., Fisher, D. R., et al. (1999) · PubMed · Cited by 572 · see citing works
Self-citationAzzam, E. I., de Toledo, S. M., Gooding, T. B., & Little, J. B. (1998) · Radiation Research · doi:10.2307/3579865 · Cited by 521 · see citing works
Valentin, J. (2003) · Annals of the ICRP · doi:10.1016/s0146-6453(03)00024-1 · Cited by 521 · see citing works
MIRD primer for absorbed dose calculations
LOEVINGER, R., Budinger, T. F., & Watson, E. E. (1988) · Medical Entomology and Zoology · Cited by 512 · see citing works
Radiation-Induced Bystander Effects: Past History and Future Directions
Mothersill, C. E., & Seymour, C. B. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0759:ribeph]2.0.co;2 · Cited by 508 · see citing works
Tumor therapy with targeted atomic nanogenerators.
McDevitt, M. R., Ma, D., Lai, L. T., Simon, J., Borchardt, P., Frank, R. K., Wu, K., Pellegrini, V., Curcio, M. J., Miederer, M., et al. (2001) · Science · doi:10.1126/science.1064126 · Cited by 501 · see citing works
Self-citationNilsson, S. F., Franzén, L., Parker, C. C., Tyrrell, C., Blom, R., Tennvall, J., Lennernäs, B., Petersson, U., Johannessen, D. C., Sokal, M., et al. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70147-x · Cited by 493 · see citing works
Induction of a bystander mutagenic effect of alpha particles in mammalian cells
Zhou, H., Randers-Pehrson, G., Waldren, C. A., Vannais, D. B., Hall, E. J., & Hei, T. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030420797 · Cited by 478 · see citing works
Targeted α particle immunotherapy for myeloid leukemia
Jurcic, J. G., Larson, S. M., Sgouros, G., McDevitt, M. R., Finn, R. D., Divgi, C. R., Ballangrud, Å., Hamacher, K. A., Ma, D., Humm, J. L., et al. (2002) · Blood · doi:10.1182/blood.v100.4.1233.h81602001233_1233_1239 · Cited by 472 · see citing works
Self-citationWikstrand, C. J., Hale, L. P., Batra, S. K., et al. (1995) · PubMed · Cited by 472 · see citing works
First Clinical Experience with α-Emitting Radium-223 in the Treatment of Skeletal Metastases
Nilsson, S. F., Larsen, R. H., Fosså, S. D., Balteskard, L., Borch, K. W., Westlin, J., Salberg, G., & Bruland, Ø. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2244 · Cited by 439 · see citing works
Zalutsky, M. R., Reardon, D. A., Akabani, G., Coleman, R. E., Friedman, A. H., Friedman, H. S., McLendon, R. E., Wong, T. Z., & Bigner, D. D. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.046938 · Cited by 414 · see citing works
Self-citationRadioimmunotherapy with alpha-emitting nuclides
McDevitt, M. R., Sgouros, G., Finn, R. D., Humm, J. L., Jurcic, J. G., Larson, S. M., & Scheinberg, D. A. (1998) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050306 · Cited by 403 · see citing works
Self-citationCurrent Topics in Radiation Research
Elkind, M. M. (1968) · Radiology · doi:10.1148/91.4.831b · Cited by 374 · see citing works
Transport of fluid and macromolecules in tumors
Baxter, L. T., & Jain, R. K. (1991) · Microvascular Research · doi:10.1016/0026-2862(91)90003-t · Cited by 368 · see citing works
Bruland, Ø. S., Nilsson, S. F., Fisher, D. R., & Larsen, R. H. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0841 · Cited by 356 · see citing works
Self-citationRadiation biology in cancer research
(1978) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(78)90242-6 · Cited by 336 · see citing works
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
Unruh, A., Ressel, A., Mohamed, H. G., Johnson, R. S., Nadrowitz, R., Richter, E., Katschinski, D. M., & Wenger, R. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206385 · Cited by 334 · see citing works
Hall, E. J., & Brenner, D. J. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90367-5 · Cited by 309 · see citing works
Lee, S. L. (2012) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328357fa0c · Cited by 306 · see citing works
Richmond, C. R. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551281 · Cited by 305 · see citing works
Ion Implantation Science and Technology
(1988) · Elsevier eBooks · doi:10.1016/b978-0-12-780621-1.x5001-1 · Cited by 304 · see citing works
Bone marrow dosimetry for radioimmunotherapy: theoretical considerations.
Sgouros, G. (1993) · PubMed · Cited by 299 · see citing works
Self-citationMonoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic
Shepard, H. M., Phillips, G. D. L., Sarup, J. C., FENDLY, B. M., Maneval, D. C., Mordenti, J. J., Figari, I. S., Kotts, C. E., Palladino, M. A., Ullrich, A., et al. (1991) · Journal of Clinical Immunology · doi:10.1007/bf00918679 · Cited by 295 · see citing works
Hartsock, R. J., Smith, E. B., & Petty, C. S. (1965) · American Journal of Clinical Pathology · doi:10.1093/ajcp/43.4.326 · Cited by 292 · see citing works
Brechbiel, M. W., Gansow, O. A., Atcher, R. W., et al. (1986) · Inorganic Chemistry · doi:10.1021/ic00236a024 · Cited by 289 · see citing works
Henriksen, G., Breistøl, K., Bruland, Ø. S., Fodstad, Ø., & Larsen, R. H. (2002) · PubMed · Cited by 279 · see citing works
Brenner, D. J., & Ward, J. F. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551591 · Cited by 275 · see citing works
Larson, S. M., Carrasquillo, J. A., Krohn, K., et al. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111175 · Cited by 262 · see citing works
Barendsen, G. W., Koot, C. J., van Kersen, G. R., et al. (1966) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553006614550421 · Cited by 259 · see citing works
An alpha-particle emitting antibody ([213Bi]J591) for radioimmunotherapy of prostate cancer.
McDevitt, M. R., Barendswaard, E., Ma, D., Lai, L. T., Curcio, M. J., Sgouros, G., Ballangrud, Å., Yang, W., Finn, R. D., Pellegrini, V., et al. (2000) · PubMed · Cited by 259 · see citing works
Self-citationBarendsen, G. W., Beusker, T. L. J., Vergroesen, A. J., et al. (1960) · Radiation Research · doi:10.2307/3570859 · Cited by 255 · see citing works
Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions
Thacker, J., Stretch, A., & Stephens, M. A. (1979) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007914550891 · Cited by 251 · see citing works
Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice.
Henriksen, G., Fisher, D. R., Roeske, J. C., Bruland, Ø. S., & Larsen, R. H. (2003) · PubMed · Cited by 250 · see citing works
Self-citationThe Relation Between Tumour Lethal Doses and the Radiosensitivity of Tumour Cells
Munro, T. R., & Gilbert, C. W. (1961) · British Journal of Radiology · doi:10.1259/0007-1285-34-400-246 · Cited by 246 · see citing works
Charlton, D. E., Nikjoo, H., & Humm, J. L. (1989) · International Journal of Radiation Biology · doi:10.1080/09553008914551141 · Cited by 243 · see citing works
Design and synthesis of 225Ac radioimmunopharmaceuticals.
McDevitt, M. R., Ma, D., Simon, J., Frank, R. K., & Scheinberg, D. A. (2002) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(02)00167-7 · Cited by 225 · see citing works
Self-citationNon-targeted bystander effects induced by ionizing radiation
Morgan, W. F., & Sowa, M. B. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.11.009 · Cited by 219 · see citing works
Production of Ac-225 from Th-229 for Targeted α Therapy
Apostolidis, C., Molinet, R., Rasmussen, G., & Morgenstern, A. (2005) · Analytical Chemistry · doi:10.1021/ac0580114 · Cited by 215 · see citing works
Hall, E. J. (2003) · Health Physics · doi:10.1097/00004032-200307000-00008 · Cited by 212 · see citing works
Barendsen, G. W., Walter, H. M. D., Fowler, J. F., & Bewley, D. K. (1963) · Radiation Research · doi:10.2307/3571430 · Cited by 211 · see citing works
Sgouros, G., Ballangrud, Å., Jurcic, J. G., McDevitt, M. R., Humm, J. L., Erdi, Y. E., Mehta, B. M., Finn, R. D., Larson, S. M., & Scheinberg, D. A. (1999) · PubMed · Cited by 207 · see citing works
Self-citationAstatine-211-Labeled Radiotherapeutics An Emerging Approach to Targeted Alpha-Particle Radiotherapy
Zalutsky, M. R., & Vaidyanathan, G. (2000) · Current Pharmaceutical Design · doi:10.2174/1381612003399275 · Cited by 203 · see citing works
Kozak, R. W., Atcher, R. W., Gansow, O. A., Friedman, A. M., Hines, J. J., Jr., & Waldmann, T. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.2.474 · Cited by 197 · see citing works
Jenner, T. J., deLara, C. M., O'Neill, P., et al. (1993) · International Journal of Radiation Biology · doi:10.1080/09553009314551421 · Cited by 189 · see citing works
(1991) · Annals of the ICRP · doi:10.1016/0146-6453(91)90065-o · Cited by 189 · see citing works
The Relative Radiosensitivity of the Nucleus and Cytoplasm of Chinese Hamster Fibroblasts
Munro, T. R. (1970) · Radiation Research · doi:10.2307/3572962 · Cited by 181 · see citing works
Goddu, S. M., Howell, R. W., & Rao, D. V. (1994) · PubMed · Cited by 177 · see citing works
Self-citationNikula, T. K., McDevitt, M. R., Finn, R. D., Wu, C., Kozak, R. W., Garmestani, K., Brechbiel, M. W., Curcio, M. J., Pippin, C. G., Tiffany-Jones, L., et al. (1999) · PubMed · Cited by 176 · see citing works
Self-citationApostolidis, C., Molinet, R., McGinley, J., Abbas, K., Möllenbeck, J., & Morgenstern, A. (2005) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2004.06.013 · Cited by 176 · see citing works
Mird: Radionuclide Data and Decay Schemes
Eckerman, K. F., & Endo, A. (1989) · CERN Document Server (European Organization for Nuclear Research) · Cited by 174 · see citing works
Cancer Stem Cells and Metastasis: Lethal Seeds
Wicha, M. S. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1537 · Cited by 174 · see citing works
Production of actinium-225 for alpha particle mediated radioimmunotherapy.
Boll, R. A., Malkemus, D., & Mirzadeh, S. (2005) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2004.12.003 · Cited by 171 · see citing works
Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus
Raju, M. R., Eisen, Y., Carpenter, S. G., & Inkret, W. C. T. (1991) · Radiation Research · doi:10.2307/3578139 · Cited by 167 · see citing works
GOODHEAD, D. T., Munson, R. J., Thacker, J., & Cox, R. (1980) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008014550201 · Cited by 166 · see citing works
The promise of targeted {alpha}-particle therapy.
Mulford, D. A., Scheinberg, D. A., & Jurcic, J. G. (2005) · PubMed · Cited by 164 · see citing works
Zalutsky, M. R., Garg, P. K., Friedman, H. S., & Bigner, D. D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7149 · Cited by 156 · see citing works
Radioimmunotherapy with Alpha-Particle-Emitting Immunoconjugates
Macklis, R. M., Kinsey, B. M., Kassis, A. I., Ferrara, J. L. M., Atcher, R. W., Hines, J. J., Jr., Coleman, C. N., Adelstein, S. J., & Burakoff, S. J. (1988) · Science · doi:10.1126/science.2897133 · Cited by 155 · see citing works
Lindegren, S., Bäck, T. A., & Jensen, H. J. (2001) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(01)00044-6 · Cited by 155 · see citing works
Bishayee, A., Hill, H. Z., von Stein, D. E., et al. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0335:friagj]2.0.co;2 · Cited by 155 · see citing works
Miederer, M., Henriksen, G., Alke, A., Mossbrugger, I., Quintanilla-Martinez, L., Senekowitsch-Schmidtke, R., & Essler, M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4647 · Cited by 155 · see citing works
Kneifel, S., Cordier, D., Good, S., Ionescu, M.-C. S., Ghaffari, A., Höfer, S., Kretzschmar, M., Tolnay, M., Apostolidis, C., Waser, B., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2820 · Cited by 153 · see citing works
Targeted actinium-225 in vivo generators for therapy of ovarian cancer.
Borchardt, P. E., Yuan, R., Miederer, M., McDevitt, M. R., & Scheinberg, D. A. (2003) · PubMed · Cited by 150 · see citing works
Self-citationBarendsen, G. W. (1962) · Nature · doi:10.1038/1931153a0 · Cited by 150 · see citing works
Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses.
Azzam, E. I., de Toledo, S. M., & Little, J. B. (2003) · PubMed · Cited by 149 · see citing works
Baxter, L. T., & Jain, R. K. (1991) · Microvascular Research · doi:10.1016/0026-2862(91)90026-8 · Cited by 146 · see citing works
Boyd, M., Ross, S. C., Dorrens, J., et al. (2006) · PubMed · Cited by 146 · see citing works
Beiträge zur Biologie der Strahlenwirkung
Holthusen, H. (1921) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01722061 · Cited by 143 · see citing works
An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation.
McDevitt, M. R., Finn, R. D., Sgouros, G., Ma, D., & Scheinberg, D. A. (1999) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(98)00151-1 · Cited by 138 · see citing works
Self-citationArtificially Radioactive Element 85
Corson, D. R., MacKenzie, K. R., & Segre, E. (1940) · Physical Review · doi:10.1103/physrev.58.672 · Cited by 137 · see citing works
Melanoma Therapy via Peptide-Targeted α-Radiation
Miao, Y., Hylarides, M. D., Fisher, D. R., Shelton, T. D., Moore, H. A., WESTER, D. W., Fritzberg, A. R., Winkelmann, C. T., Hoffman, T. J., & Quinn, T. P. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0619 · Cited by 136 · see citing works
Self-citationDNA damage induced by radiation of different linear energy transfer: initial fragmentation
Höglund, E. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138556 · Cited by 135 · see citing works
Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells
Iyer, R. S., & Lehnert, B. E. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)157[0003:apiiit]2.0.co;2 · Cited by 135 · see citing works
MIRD : radionuclide data and decay schemes
Weber, D. A., & Dillman, L. T. (1989) · Society of Nuclear Medicine eBooks · Cited by 131 · see citing works
Improved in Vivo Stability of Actinium-225 Macrocyclic Complexes
Deal, K. A., Davis, I. A., Mirzadeh, S., Kennel, S. J., & Brechbiel, M. W. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990141f · Cited by 130 · see citing works
Behr, T. M., Béhé, M. P., Stabin, M. G., Wehrmann, E., Apostolidis, C., Molinet, R., Strutz, F., Fayyazi, A., Wieland, E., Gratz, S., et al. (1999) · PubMed · Cited by 127 · see citing works
Goddu, S. M., Rao, D. V., & Howell, R. W. (1994) · PubMed · Cited by 125 · see citing works
Self-citationOCCUPATIONAL POISONING IN MANUFACTURE OF LUMINOUS WATCH DIALS
Martland, H. S. (1929) · JAMA · doi:10.1001/jama.1929.92700320002013 · Cited by 125 · see citing works
Qu, C., Li, Y., Song, Y., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602232 · Cited by 125 · see citing works
Bishayee, A., Rao, D. V., & Howell, R. W. (1999) · Radiation Research · doi:10.2307/3580054 · Cited by 125 · see citing works
Self-citationIntralesional targeted alpha therapy for metastatic melanoma
Allen, B., Raja, C., Rizvi, S. M., Li, Y., Tsui, W., Graham, P., Thompson, J. A., Reisfeld, R. A., Kearsley, J. H., Morgenstern, A., et al. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.12.2251 · Cited by 124 · see citing works
Self-citationMiederer, M., McDevitt, M. R., Sgouros, G., Kramer, K., Cheung, N. V., & Scheinberg, D. A. (2004) · PubMed · Cited by 119 · see citing works
Self-citationEngineered liposomes for potential alpha-particle therapy of metastatic cancer.
Sofou, S., Thomas, J. L., Lin, H. Y., McDevitt, M. R., Scheinberg, D. A., & Sgouros, G. (2004) · PubMed · Cited by 119 · see citing works
Self-citationMutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions
Cox, R., & Masson, W. K. (1979) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007914550901 · Cited by 118 · see citing works
(2007) · Annals of the ICRP · doi:10.1016/j.icrp.2008.08.001 · Cited by 116 · see citing works
Brechbiel, M. W., & Gansow, O. A. (1992) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/p19920001173 · Cited by 115 · see citing works
Barendsen, G. W. (1964) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553006414550561 · Cited by 113 · see citing works
Preparation of alpha-emitting 213Bi-labeled antibody constructs for clinical use.
McDevitt, M. R., Finn, R. D., Ma, D., Larson, S. M., & Scheinberg, D. A. (1999) · PubMed · Cited by 112 · see citing works
Self-citationThe assessment of RBE effects using the concept of biologically effective dose
Dale, R., & Jones, B. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00364-2 · Cited by 111 · see citing works
Hamilton, J. G., & Soley, M. H. (1940) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1940.131.1.135 · Cited by 110 · see citing works
A microdosimetric model of astatine-211 labeled antibodies for radioimmunotherapy
Humm, J. L. (1987) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(87)90176-3 · Cited by 110 · see citing works
Macklis, R. M., Lin, J. Y., Beresford, B. A., Atcher, R. W., Hines, J. J., Jr., & Humm, J. L. (1992) · Radiation Research · doi:10.2307/3578279 · Cited by 109 · see citing works
Criteria for the Applicability of LET
Kellerer, A. M., & Chmelevsky, D. (1975) · Radiation Research · doi:10.2307/3574148 · Cited by 109 · see citing works
deLara, C. M., Jenner, T. J., Townsend, K. M. S., et al. (1995) · Radiation Research · doi:10.2307/3579234 · Cited by 108 · see citing works
Kirschner, A. S., Ice, R. D., & Beierwaltes, W. H. (1975) · Journal of Nuclear Medicine · Cited by 108 · see citing works
Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection
Dadachova, E., Nakouzi, A. S., Bryan, R. A., & Casadevall, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1731272100 · Cited by 107 · see citing works
Barendsen, G. W. (1994) · Radiation Research · doi:10.2307/3578823 · Cited by 107 · see citing works
Larsen, R. H., Wieland, B. W., & Zalutsky, M. R. (1996) · Applied Radiation and Isotopes · doi:10.1016/0969-8043(95)00285-5 · Cited by 106 · see citing works
Barendsen, G. W., & Walter, H.-K. (1964) · Radiation Research · doi:10.2307/3571569 · Cited by 105 · see citing works
Comparison of 225actinium chelates: tissue distribution and radiotoxicity
Davis, I. A., Glowienka, K. A., Boll, R. A., Deal, K. A., Brechbiel, M. W., Stabin, M. G., Bochsler, P. N., Mirzadeh, S., & Kennel, S. J. (1999) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(99)00024-4 · Cited by 105 · see citing works
Ballangrud, Å., Yang, W.-H., Palm, S., Enmon, R. M., Borchardt, P. E., Pellegrini, V., McDevitt, M. R., Scheinberg, D. A., & Sgouros, G. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0800 · Cited by 105 · see citing works
Self-citationNorenberg, J. P., Krenning, B. J., Konings, I. R. H. M., Kusewitt, D. F., Nayak, T. K., Anderson, T. L., de Jong, M., Garmestani, K., Brechbiel, M. W., & Kvols, L. K. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1264 · Cited by 104 · see citing works
Zhang, M., Yao, Z., Garmestani, K., Axworthy, D. B., Zhang, Z., Mallett, R. W., Theodore, L. J., Goldman, C. K., Brechbiel, M. W., Carrasquillo, J. A., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0107 · Cited by 103 · see citing works
The centenary of the discovery of the Bragg peak
Brown, A., & Suit, H. D. (2004) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2004.09.008 · Cited by 102 · see citing works
Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate
Zalutsky, M. R., & Narula, A. S. (1988) · International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes · doi:10.1016/0883-2889(88)90176-1 · Cited by 102 · see citing works
Rejoining of DNA fragments produced by radiations of different linear energy transfer
Stenerlöw, B. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138565 · Cited by 102 · see citing works
MICROSCOPIC ENERGY DISTRIBUTION IN IRRADIATED MATTER
Rossi, H. H. (1968) · Elsevier eBooks · doi:10.1016/b978-0-12-066401-6.50009-9 · Cited by 100 · see citing works
Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells
Mattes, M. J., Griffiths, G. L., Diril, H., Goldenberg, D. M., Ong, G. L., & Shih, L. B. (1994) · Cancer · doi:10.1002/1097-0142(19940201)73:3+ · Cited by 98 · see citing works
Efforts to Control the Errant Products of a Targeted <i>In vivo</i> Generator
Singh Jaggi, J., Kappel, B. J., McDevitt, M. R., Sgouros, G., Flombaum, C. D., Cabassa, C., & Scheinberg, D. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3096 · Cited by 98 · see citing works
Self-citationBallangrud, Å., Yang, W., Charlton, D. E., McDevitt, M. R., Hamacher, K. A., Panageas, K. S., Ma, D., Bander, N. H., Scheinberg, D. A., & Sgouros, G. (2001) · PubMed · Cited by 98 · see citing works
Self-citationSandmaier, B. M., Bethge, W. A., Wilbur, D. S., Hamlin, D. K., Santos, E. B., Brechbiel, M. W., Fisher, D. R., & Storb, R. F. (2002) · Blood · doi:10.1182/blood-2001-12-0322 · Cited by 95 · see citing works
Self-citationThe feasibility of 225 Ac as a source of ??-particles in radioimmunotherapy
Geerlings, M. W., Kaspersen, F. M., Apostolidis, C., & van der Hout, R. (1993) · Nuclear Medicine Communications · doi:10.1097/00006231-199302000-00009 · Cited by 95 · see citing works
Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers
Sofou, S., Kappel, B. J., Jaggi, J. S., McDevitt, M. R., Scheinberg, D. A., & Sgouros, G. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070075t · Cited by 94 · see citing works
Self-citationA Model of Cell Inactivation by Alpha-Particle Internal Emitters
Humm, J. L., & Chin, L. M. (1993) · Radiation Research · doi:10.2307/3578453 · Cited by 93 · see citing works
Astatine-211—Tellurium Radiocolloid Cures Experimental Malignant Ascites
Bloomer, W. D., McLaughlin, W., Neirinckx, R. D., et al. (1981) · Science · doi:10.1126/science.7209534 · Cited by 89 · see citing works
Jaggi, J. S., Seshan, S. V., McDevitt, M. R., LaPerle, K., Sgouros, G., & Scheinberg, D. A. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004110945 · Cited by 89 · see citing works
Self-citationRadioimmunotherapy with alpha-particle emitting radionuclides.
Zalutsky, M. R., & Pozzi, O. R. (2004) · PubMed · Cited by 88 · see citing works
Inactivation of Synchronized Chinese Hamster V79 Cells with Charged-Particle Track Segments
Bird, R. P., Rohrig, N., Colvett, R. D., Geard, C. R., & Marino, S. A. (1980) · Radiation Research · doi:10.2307/3575379 · Cited by 88 · see citing works
Howell, R. W., Rao, D. V., Hou, D., et al. (1991) · Radiation Research · doi:10.2307/3578051 · Cited by 88 · see citing works
Self-citationEffective alpha-particle-mediated radioimmunotherapy of murine leukemia.
Huneke, R. B., Pippin, C. G., Squire, R. A., Brechbiel, M. W., Gansow, O. A., & Strand, M. (1992) · PubMed · Cited by 86 · see citing works
Adams, G. P., Shaller, C. C., Chappell, L. L., Wu, C., Horak, E. M., Simmons, H. H., Litwin, S., Marks, J. D., Weiner, L. M., & Brechbiel, M. W. (2000) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(00)00103-7 · Cited by 83 · see citing works
Chappell, L. L., Deal, K. A., Dadachova, E., & Brechbiel, M. W. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990153f · Cited by 82 · see citing works
Evaluation of 225 Ac for Vascular Targeted Radioimmunotherapy of Lung Tumors
Kennel, S. J., Chappell, L. L., Dadachova, K., Brechbiel, M. W., Lankford, T. K., Davis, I. A., Stabin, M. G., & Mirzadeh, S. (2000) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/108497800414329 · Cited by 82 · see citing works
Bloomer, W. D., McLaughlin, W., Lambrecht, R. M., et al. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90052-x · Cited by 82 · see citing works
Thorotrast-induced cancer in man
Baserga, R., Yokoo, H., & Henegar, G. C. (1960) · Cancer · doi:10.1002/1097-0142(196009/10)13:5 · Cited by 81 · see citing works
Vaidyanathan, G., & Zalutsky, M. R. (1992) · Bioconjugate Chemistry · doi:10.1021/bc00018a006 · Cited by 81 · see citing works
Hadley, S. W., Wilbur, D. S., Gray, M. A., et al. (1991) · Bioconjugate Chemistry · doi:10.1021/bc00009a006 · Cited by 80 · see citing works
Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate
Dahle, J., Borrebæk, J., Jónasdóttir, T. J., Hjelmerud, A. K., Melhus, K. B., Bruland, Ø. S., Press, O. W., & Larsen, R. H. (2007) · Blood · doi:10.1182/blood-2007-01-066803 · Cited by 80 · see citing works
The Radiation-Induced Bystander Effect for Clonogenic Survival
Sawant, S. G., Zheng, W., Hopkins, K. M., et al. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)157[0361:tribef]2.0.co;2 · Cited by 80 · see citing works
Persaud, R., Zhou, H., Baker, S. E., Hei, T. K., & Hall, E. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2875 · Cited by 79 · see citing works
Zalutsky, M. R., McLendon, R. E., Garg, P., Archer, G. E., Schuster, J. M., & Bigner, D. D. (1994) · PubMed · Cited by 79 · see citing works
Mitigation of radiation nephropathy after internal α-particle irradiation of kidneys
Jaggi, J. S., Seshan, S. V., McDevitt, M. R., Sgouros, G., Hyjek, E. M., & Scheinberg, D. A. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.11.036 · Cited by 78 · see citing works
Self-citationHarrison, J. D., & Muirhead, C. R. (2003) · International Journal of Radiation Biology · doi:10.1080/0955300021000038671 · Cited by 78 · see citing works
Improved point kernels for electron and beta-ray dosimetry
Berger, M. J. (1973) · doi:10.6028/nbs.ir.73-107 · Cited by 77 · see citing works
Alpha- and beta-emitting radiolanthanides in targeted cancer therapy
Allen, B., & Blagojevic, N. (1996) · Nuclear Medicine Communications · doi:10.1097/00006231-199601000-00008 · Cited by 75 · see citing works
Self-citationTargeting of HER2 Antigen for the Treatment of Disseminated Peritoneal Disease
Milenic, D. E., Garmestani, K., Brady, E. D., Albert, P. S., Ma, D., Abdulla, A., & Brechbiel, M. W. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1226 · Cited by 75 · see citing works
Rao, D., Howell, R. W., Narra, V. R., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90896-9 · Cited by 75 · see citing works
Self-citationLi, Y., Rizvi, S. M., Ranson, M., & Allen, B. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600179 · Cited by 73 · see citing works
Self-citationChang, M.-Y., Seideman, J. H., & Sofou, S. (2008) · Bioconjugate Chemistry · doi:10.1021/bc700440a · Cited by 73 · see citing works
Barendsen, G. W., & Beusker, T. L. J. (1960) · Radiation Research · doi:10.2307/3570858 · Cited by 73 · see citing works
Production routes of the alpha emitting 149 Tb for medical application
Beyer, G. J., Comor, J. J., Daković, M. Z., Soloviev, D., Tamburella, C., Hagebø, E., Allan, B., Dmitriev, S. N., & Zaitseva, N. G. (2002) · Radiochimica Acta · doi:10.1524/ract.2002.90.5_2002.247 · Cited by 72 · see citing works
Elgqvist, J., Andersson, H., Bäck, T. A., Hultborn, R., Jensen, H. J., Karlsson, B., Lindegren, S., Palm, S., Warnhammar, E., & Jacobsson, L. (2005) · PubMed · Cited by 72 · see citing works
Self-citationRadioimmunotherapy of micrometastases in lung with vascular targeted213Bi
Kennel, S. J., Boll, R. A., Stabin, M. G., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690337 · Cited by 70 · see citing works
Monoclonal antibodies : applications in clinical oncology
Epenetos, A. A. (1991) · Chapman & Hall Medical eBooks · Cited by 69 · see citing works
Generator-produced alpha-emitters
Mirzadeh, S. (1998) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(97)00175-9 · Cited by 69 · see citing works
Hartmann, F., Horak, E. M., Garmestani, K., Wu, C., Brechbiel, M. W., Kozak, R. W., Tso, J. Y., Kosteiny, S. A., Gansow, O. A., & Nelson, D. L. (1994) · PubMed · Cited by 69 · see citing works
Elgqvist, J., Andersson, H., Bäck, T. A., et al. (2006) · PubMed · Cited by 68 · see citing works
Nikula, T. K., Curcio, M. J., Brechbiel, M. W., et al. (1995) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)00126-5 · Cited by 67 · see citing works
The Promise of Targeted α-Particle Therapy
Mulford, D. A., Scheinberg, D. A., & Jurcic, J. G. (2005) · Journal of Nuclear Medicine · Cited by 67 · see citing works
Rao, D. V., Narra, V. R., Howell, R. W., et al. (1991) · Radiation Research · doi:10.2307/3577986 · Cited by 67 · see citing works
Self-citationVascular Targeted Radioimmunotherapy with 213Bi—An α-Particle Emitter
Kennel, S. J., & Mirzadeh, S. (1998) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(97)00200-x · Cited by 66 · see citing works
Neti, P. V. S. V., & Howell, R. W. (2006) · PubMed · Cited by 66 · see citing works
Self-citationThe use of hypnosis in the care of the cancer patient
Butler, B. C. (1954) · Cancer · doi:10.1002/1097-0142(195401)7:1 · Cited by 65 · see citing works
Feinendegen, L. E., & McClure, J. J. (1997) · Radiation Research · doi:10.2307/3579579 · Cited by 65 · see citing works
Cell Survival Following Multiple-track Alpha Particle Irradiation
Lloyd, E. L., Gemmell, M. A., Henning, C. B., Gemmell, D. S., & Zabransky, B. J. (1979) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007914550031 · Cited by 64 · see citing works
A Generic Age-Specific Biokinetic Model for Calcium-like Elements
Leggett, R. W. (1992) · Radiation Protection Dosimetry · doi:10.1093/oxfordjournals.rpd.a081254 · Cited by 64 · see citing works
Howell, R. W., Goddu, S. M., Narra, V. R., Fisher, D. R., Schenter, R. E., & Rao, D. V. (1997) · Radiation Research · doi:10.2307/3579342 · Cited by 62 · see citing works
Self-citationAllen, B., Tian, Z., Rizvi, S. M., Li, Y., & Ranson, M. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600838 · Cited by 61 · see citing works
Self-citationPreparation of a biologically stable and immunogenically competent astatinated protein
Friedman, A. M., Zalutsky, M. R., Wung, W. E., et al. (1977) · International Journal of Nuclear Medicine and Biology · doi:10.1016/0047-0740(77)90146-2 · Cited by 60 · see citing works
Targeted alpha therapy for cancer
Allen, B., Raja, C., Rizvi, S. M., et al. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/16/016 · Cited by 60 · see citing works
Self-citationEvidence for ‘bystander effects’ in vivo
Brooks, A. L. (2004) · Human & Experimental Toxicology · doi:10.1191/0960327104ht419oa · Cited by 59 · see citing works
Rydberg, B., Cooper, B., Cooper, P. K., Holley, W. R., & Chatterjee, A. (2004) · eScholarship (California Digital Library) · Cited by 58 · see citing works
Reist, C. J., Foulon, C. F., Alston, K. L., et al. (1999) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(98)00120-6 · Cited by 57 · see citing works
Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
Dahle, J., Borrebæk, J., Melhus, K. B., Bruland, Ø. S., Salberg, G., Olsen, D. R., & Larsen, R. H. (2006) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.12.004 · Cited by 57 · see citing works
Kvinnsland, Y., Stokke, T., & Aurlien, E. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0288:rwapem]2.0.co;2 · Cited by 57 · see citing works
Milenic, D. E., Roselli, M., Mirzadeh, S., Pippin, C. G., Gansow, O. A., Colcher, D. M., Brechbiel, M. W., & Schlom, J. (2001) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/108497801300189227 · Cited by 56 · see citing works
Model of DNA Damage Induced by Radiations of Various Qualities
Michalik, V. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551781 · Cited by 55 · see citing works
Production of terbium-152 by heavy ion reactions and proton induced spallation
Allen, B., Goozée, G., Sarkar, S., et al. (2001) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(00)00164-0 · Cited by 55 · see citing works
Self-citationBoyd, M., Mairs, R. J., Keith, W. N., Ross, S. C., Welsh, P. C., Akabani, G., Owens, J., Vaidyanathan, G., Carruthers, R., Dorrens, J., et al. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.578 · Cited by 55 · see citing works
Self-citationConsiderations of marrow cellularity in 3-dimensional dosimetric models of the trabecular skeleton.
Bolch, W. E., Patton, P. W., Rajon, D. A., et al. (2002) · PubMed · Cited by 55 · see citing works
Link, E. M., Brown, I., Carpenter, R. N., et al. (1989) · PubMed · Cited by 54 · see citing works
Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells.
Strickland, D. K., Vaidyanathan, G., & Zalutsky, M. R. (1994) · PubMed · Cited by 54 · see citing works
Brooks, A. L., Retherford, J. C., & McClellan, R. O. (1974) · Radiation Research · doi:10.2307/3574086 · Cited by 54 · see citing works
Miederer, M., McDevitt, M. R., Borchardt, P. E., Bergman, I., Kramer, K., Cheung, N. V., & Scheinberg, D. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0859 · Cited by 54 · see citing works
Self-citationHarrison, G. E., Carr, T. E. F., & Sutton, A. (1968) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553006814550161 · Cited by 54 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [59]Machinami R Ishikawa Y Boecker BB The international workshop on health effects of Thorotrast, radium, radon and other alpha-emitters, 1999 [preface] Radiat Res 1999 152 suppl S1 S2
- [68]Oliveira NG Castro M Rodrigues AS Wortmannin enhances the induction of micronuclei by low and high LET radiation [erratum] Mutagenesis 2003 18 217 12621080
- [100]Fisher DR The microdosimetry of monoclonal antibodies labeled with alpha emitters Schlafke-Stelson AT Watson EE Fourth International Radiopharmaceutical Dosimetry Symposium Oak Ridge, TN Oak Ridge Associated Universities 1986 26 36
- [103]Kellerer AM Analysis of patterns of energy deposition: a survey of theoretical relations in microdosimetry Ebert HG Proceedings of the Second Symposium on Microdosimetry Brussels, Belgium Commission of European Communities 1970 107 134
- [153]Goodhead DT Talk 23, Alpha Emitters, from Session 6, Effects from Specific Sources of Internal Radiation Presented at: CERRIE Workshop July 21–23, 2003 Oxford, U.K.
Cited by
Sorted by citations
Kratochwil, C., Bruchertseifer, F., Rathke, H., Bronzel, M., Apostolidis, C., Weichert, W., Haberkorn, U., Giesel, F. L., & Morgenstern, A. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.191395 · Cited by 505 · see citing works
Development of <sup>225</sup>Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences
Robertson, A. K. H., Ramogida, C. F., Schaffer, P., & Radchenko, V. (2018) · Current Radiopharmaceuticals · doi:10.2174/1874471011666180416161908 · Cited by 202 · see citing works
Development of targeted alpha particle therapy for solid tumors.
Tafreshi, N. K., Doligalski, M. L., Tichacek, C. J., Pandya, D. N., Budzevich, M. M., El-Haddad, G., Khushalani, N. I., Moros, E. G., McLaughlin, M. L., Wadas, T. J., et al. (2019) · Molecules · doi:10.3390/molecules24234314 · Cited by 157 · see citing works
Graf, F., Fahrer, J., Maus, S., Morgenstern, A., Bruchertseifer, F., Venkatachalam, S., Fottner, C., Weber, M. M., Huelsenbeck, J., Schreckenberger, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088239 · Cited by 143 · see citing works
Variations in Clinical PET/CT Operations: Results of an International Survey of Active PET/CT Users
Beyer, T., Czernin, J., & Freudenberg, L. S. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.079624 · Cited by 136 · see citing works
A bone marrow toxicity model for <sup>223</sup> Ra alpha-emitter radiopharmaceutical therapy
Hobbs, R. F., Song, H., Watchman, C. J., Bolch, W. E., Aksnes, A.-K., Ramdahl, T., Flux, G. D., & Sgouros, G. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/10/3207 · Cited by 122 · see citing works
Self-citationBismuth-213 for targeted radionuclide therapy: from atom to bedside.
Ahenkorah, S., Cassells, I., Deroose, C. M., Cardinaels, T., Burgoyne, A. R., Bormans, G., Ooms, M., & Cleeren, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050599 · Cited by 120 · see citing works
Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95 · see citing works
Self-citationTagawa, S. T., Thomas, C., Sartor, A. O., Sun, M., Stangl-Kremser, J., Bissassar, M., Vallabhajosula, S., Castellanos, S. H., Nauseef, J. T., Sternberg, C. N., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.23.00573 · Cited by 78 · see citing works
A nephron-based model of the kidneys for macro-to-micro α-particle dosimetry
Hobbs, R. F., Song, H., Huso, D. L., H Sundel, M., & Sgouros, G. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/13/4403 · Cited by 61 · see citing works
Self-citationVatsa, R., Sood, A., Vadi, S. K., Das, C. K., Kaur, K., Parmar, M., & Mittal, B. R. (2020) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000003031 · Cited by 23 · see citing works
The Role of Preclinical Models in Radiopharmaceutical Therapy
Sgouros, G., Hobbs, R. F., & Abou, D. S. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e121 · Cited by 16 · see citing works
Self-citation
- Authors
- Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G.
- Affiliations
- Johns Hopkins University (US)
- Loyola University Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- International Atomic Energy Agency (AT)
- Pacific Northwest National Laboratory (US)
- Vanderbilt University (US)
- Rutgers, The State University of New Jersey (US)
- Texas A&M University (US)
- ORCID
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2010-01-15
- Volume
- 51
- Issue
- 2
- Pages
- 311-328
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- PMC
- PMC5680544
- OpenAlex
- W2018649196
- Cited by
- 552
- References
- 363
- Citations by year
- 2026: 60 · 2025: 58 · 2024: 50 · 2023: 54 · 2022: 50 · 2021: 50 · 2020: 39 · 2019: 34 · 2018: 44 · 2017: 17 · 2016: 21 · 2015: 10 · 2014: 25 · 2013: 11 · 2012: 16
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005136)
- National Cancer Institute (R01CA109234, R41CA117599, P30CA008748)
- National Institute of Biomedical Imaging and Bioengineering (R01EB001994)
- National Center for Research Resources (R43RR015155)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Health Professions › Radiological and Ultrasound Technology › Radioactivity and Radon Measurements
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- alpha-emitting radionuclides, targeted alpha therapy, radiation biology, dosimetry, radionuclide conjugation, radiopharmaceuticals, cancer therapy
- MeSH terms
- Alpha Particles, Cell Survival, Clinical Trials as Topic, Dose-Response Relationship, Radiation, Female, Humans, Male, Neoplasms, Neoplasms, Radiation-Induced, Pamphlets, Radiation-Protective Agents, Radiobiology, Radioisotopes, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Relative Biological Effectiveness, Societies, Medical, Cell Death
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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