Radiation-induced Lipid Peroxidation: Influence of Oxygen Concentration and Membrane Lipid Composition
Abstract
Radiation-induced lipid peroxidation in phospholipid liposomes was investigated in terms of its dependence on lipid composition and oxygen concentration. Non-peroxidizable lipid incorporated in the liposomes reduced the rate of peroxidation of the peroxidizable phospholipid acyl chains, possibly by restricting the length of chain reactions. The latter effect is believed to be caused by interference of the non-peroxidizable lipids in the bilayer. At low oxygen concentration lipid peroxidation was reduced. The cause of this limited peroxidation may be a reduced number of radical initiation reactions possibly involving oxygen-derived superoxide radicals. Killing of proliferating mammalian cells, irradiated at oxygen concentrations ranging from 0 to 100 per cent, appeared to be independent of the concentration of peroxidizable phospholipids in the cell membranes. This indicates that lipid peroxidation is not the determining process in radiation-induced reproductive cell death.
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Radiation produces reactive oxygen species, which can lead to oxidation of biomolecules such as lipids.
“In addition to DNA damage, radiation also produces reactive oxygen species, which can lead to the oxidation of biomolecules, such as lipids6.”
From An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer (2026) · cites this paper as [6]
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[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994 · see citing works
Cheng, C., Sun, L., Yang, J., Liu, Z., Zhang, F., Qiu, L., Yu, M., Wang, T., Huang, J., Wang, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73682-0
- Authors
- Wolters, H., van Tilburg, C. A. M., & Konings, A. W. T.
- Affiliations
- University of Groningen (NL)
- Venue
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 51
- Issue
- 4
- Pages
- 619-628
- ISSN
- 0020-7616 (ISSN-L)
- OpenAlex
- W1988305884
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2013: 1
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- radiation-induced lipid peroxidation, oxygen concentration, membrane lipid composition, phospholipid liposomes, superoxide, radical chain reaction, radiation-induced cell death, mammalian cells
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Fatty Acids, Unsaturated, Lipid Peroxides, Liposomes, Membrane Lipids, Oxygen, Structure-Activity Relationship, X-Rays, Mice
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