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The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review
Abstract
The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage yield modulation; numbers of OH. free radicals reacting with the target, and amount of chemical repair occurring on the target radicals. These factors are discussed in the light of the structures within which cellular DNA is packaged and the known rate constants for the reactions involved. It is concluded from our current knowledge that, in the presence of oxygen: (a) the number of DNA dsb is linearly related to dose, and (b) the yields of DNA damage per dose among cell types are constant. There is a caveat to the latter conclusion: the chromatin structure may be different in radiosensitive cell lines. In the absence of such a difference, variations in radiosensitivity with dose or with cell type are assigned to differences in repair speed and/or accuracy.
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Citations
Cited by
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
Pfeiffer, P. (2000) · Mutagenesis · doi:10.1093/mutage/15.4.289 · Cited by 462
Human minisatellite mutation rate after the Chernobyl accident
Dubrova, Y. E., Nesterov, V. N., Krouchinsky, N. G., Ostapenko, V. A., Neumann, R., Neil, D. L., & Jeffreys, A. J. (1996) · Nature · doi:10.1038/380683a0 · Cited by 408
Mladenov, E., & Iliakis, G. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.02.005 · Cited by 381
DNA double-strand break end synapsis by DNA loop extrusion
Yang, J. H., Brandão, H. B., & Hansen, A. S. (2023) · Nature Communications · doi:10.1038/s41467-023-37583-w · Cited by 36
Metadata
- Authors
- Ward, J. F.
- Venue
- International Journal of Radiation Biology
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 57
- Issue
- 6
- Pages
- 1141-1150
- ISSN
- 0955-3002 (ISSN-L)
- 1362-3095
- OpenAlex
- W1999035626
- Cited by
- 313
- References
- 0
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ward, J. F. (1990). The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review. International Journal of Radiation Biology. https://doi.org/10.1080/09553009014551251
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
