The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
Abstract
DNA double-strand breaks (DSB) are considered to be critical primary lesions in the formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as ionizing radiation, but also occur spontaneously during cellular processes at quite significant frequencies. To repair this potentially lethal damage, eukaryotic cells have evolved a variety of repair pathways related to homologous and illegitimate recombination, also called non-homologous DNA end joining, which may induce small scale mutations and chromosomal aberrations. In this paper we review the major cellular sources of spontaneous DSB and the different homologous and illegitimate recombination repair pathways, with particular focus on their potential to induce chromosomal aberrations.
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Cited by
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,625
Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499
Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
Linardopoulou, E. V., Williams, E. M., Fan, Y., Friedman, C., Young, J. M., & Trask, B. J. (2005) · Nature · doi:10.1038/nature04029 · Cited by 448
The Fine-Scale and Complex Architecture of Human Copy-Number Variation
Perry, G. H., Ben-Dor, A., Tsalenko, A., Sampas, N., Rodriguez-Revenga, L., Tran, C. W., Scheffer, A., Steinfeld, I., Tsang, P., Yamada, N. A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.010 · Cited by 346
Metadata
- Authors
- Pfeiffer, P.
- Venue
- Mutagenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 15
- Issue
- 4
- Pages
- 289-302
- ISSN
- 0267-8357 (ISSN-L)
- 1464-3804
- OpenAlex
- W2133323814
- Cited by
- 462
- References
- 146
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pfeiffer, P. (2000). Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis. https://doi.org/10.1093/mutage/15.4.289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
