The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Cellular mechanisms of cadmium-induced toxicity: a review
Abstract
Cadmium is a widespread toxic pollutant of occupational and environmental concern because of its diverse toxic effects: extremely protracted biological half-life (approximately 20-30 years in humans), low rate of excretion from the body and storage predominantly in soft tissues (primarily, liver and kidneys). It is an extremely toxic element of continuing concern because environmental levels have risen steadily due to continued worldwide anthropogenic mobilization. Cadmium is absorbed in significant quantities from cigarette smoke, food, water and air contamination and is known to have numerous undesirable effects in both humans and animals. Cadmium has a diversity of toxic effects including nephrotoxicity, carcinogenicity, teratogenicity and endocrine and reproductive toxicities. At the cellular level, cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. Current evidence suggests that exposure to cadmium induces genomic instability through complex and multifactorial mechanisms. Most important seems to be cadmium interaction with DNA repair mechanism, generation of reactive oxygen species and induction of apoptosis. In this article, we have reviewed recent developments and findings on cadmium toxicology.
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Cites
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Cited by
The effects of cadmium toxicity
Genchi, G., Sinicropi, M. S., Lauria, G., Carocci, A., & Catalano, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113782 · Cited by 2,722
Cadmium Toxicity and Health Effects—A Brief Summary
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Bioremediation Options for Heavy Metal Pollution
Kapahi, M., & Sachdeva, S. (2019) · Journal of Health and Pollution · doi:10.5696/2156-9614-9.24.191203 · Cited by 396
Metals and Mechanisms of Carcinogenesis
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Metadata
- Authors
- Rani, A., Kumar, A., Lal, A., & Pant, M.
- Venue
- International Journal of Environmental Health Research
- Publisher
- Informa UK Limited
- Published
- 2013-10-11
- Volume
- 24
- Issue
- 4
- Pages
- 378-399
- ISSN
- 0960-3123 (ISSN-L)
- 1369-1619
- OpenAlex
- W2022434891
- Cited by
- 719
- References
- 119
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rani, A., Kumar, A., Lal, A., & Pant, M. (2014). Cellular mechanisms of cadmium-induced toxicity: a review. International Journal of Environmental Health Research. https://doi.org/10.1080/09603123.2013.835032
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
