The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Suppression of tumor necrosis factor‐alpha‐induced neutrophil adherence responses by essential oils
Open accessAbstract
BACKGROUND: In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS: To assess their anti-inflammatory activities, effects of essential oils on neutrophil activation were examined in vitro. METHODS: Neutrophil activation was measured by tumor necrosis factor-alpha (TNF-alpha)-induced adherence reaction of human peripheral neutrophils. RESULTS: All essential oils tested at 0.1% concentration suppressed TNF-alpha-induced neutrophil adherence,and, in particular, lemongrass, geranium and spearmint oils clearly lowered the reaction even at 0.0125%. Similar inhibitory activities for the neutrophil adherence were obtained by their major constituent terpenoids: citral, geraniol, citronellol and carvone. In contrast, very popular essential oils, tea tree oil and lavender oil, did not display the inhibitory activity at the concentration. CONCLUSION: Thus, some essential oils used as antiinflammatory remedies suppress neutrophil activation by TNF-alpha at a low concentration (0.0125-0.025 %) in vitro.
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“Whether some essential oils are able to inhibit the production of pro-inflammatory cytokines such as TNF-α, some of them, particularly lemongrass, geranium and spearmint and their main components (citral, geraniol, citronellol, and carvone), can also suppress TNF-α-induced neutrophil adherence responses [120]. According to these authors, those essential oils or their major components do not affect”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [120]
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Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers
Godwin, D., & Michniak, B. B. (1999) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-100102251 · Cited by 138
Lavender Oil Inhibits Immediate-type Allergic Reaction in Mice and Rats
Kim, H., & Cho, S.-H. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772178 · Cited by 120
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Tea tree oil reduces histamine-induced oedema in murine ears
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Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
Carson, C. F., Hammer, K. A., & Riley, T. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.50-62.2006 · Cited by 1,429
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933
A Review on Anti-Inflammatory Activity of Monoterpenes
Sá, R. D. C. D. S. E., Andrade, L., & de Sousa, D. P. (2013) · Molecules · doi:10.3390/molecules18011227 · Cited by 579
Geraniol — A review of a commercially important fragrance material
Chen, W., & Viljoen, A. M. (2010) · South African Journal of Botany · doi:10.1016/j.sajb.2010.05.008 · Cited by 559
Chemistry, bioactivities, mode of action and industrial applications of essential oils
Jugreet, S., Suroowan, S., Rengasamy, K. R. R., & Mahomoodally, M. F. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.04.025 · Cited by 335
Metadata
- Authors
- Abe, S., Maruyama, N., Hayama, K., Ishibashi, H., Inoue, S., Oshima, H., & Yamaguchi, H.
- Affiliations
- Teikyo University (JP)
- Corresponding author
- Abe, Shigeru
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2003-01
- Volume
- 12
- Issue
- 6
- Pages
- 323-328
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC1781633
- OpenAlex
- W2130421481
- Cited by
- 107
- References
- 20
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Kampo Medicine Research Fund
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- essential oils, anti-inflammatory activity, neutrophil activation, neutrophil adhesion, TNF-α, aromatherapy, lemongrass essential oil, geranium oil, spearmint oil, terpenoids, citral, geraniol, citronellol, carvone, tea tree oil, lavender essential oil
- MeSH terms
- Acyclic Monoterpenes, Cyclohexane Monoterpenes, Cell Adhesion, Cells, Cultured, Dose-Response Relationship, Drug, Humans, Lipopolysaccharides, Neutrophils, Oils, Volatile, Terpenes, Tetradecanoylphorbol Acetate, Tumor Necrosis Factor-alpha, Monoterpenes
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