The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Effects of Tyrosine, Phentermine, Caffeined-amphetamine, and Placebo on Cognitive and Motor Performance Deficits During Sleep Deprivation
Abstract
Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men. Tests of visual scanning, running memory, logical reasoning, mathematical processing, the Stroop task, four-choice serial reaction time, time wall take, pursuit tracking, visual vigilance, Trails (B) task and long-term memory were evaluated at standardized intervals before, during and after sleep deprivation and drugs. Performance decrements with sleep deprivation occurred in visual scanning, running memory, logical reasoning, mathematical processing, the Stroop test, the time wall test, tracking and visual vigilance. Interestingly, with sleep deprivation some tests improved and others did not deteriorate. Improvements with medication following sleep deprivation were seen in running memory, logical reasoning, mathematical processing, tracking and visual vigilance. Although less effective than D-amphetamine, tyrosine improved performance on several tests. We conclude that all drugs tested improved at least some aspects of cognitive and motor performance after sleep deprivation. As a naturally occurring amino acid, and thus amenable to nutritional strategies, tyrosine may deserve further testing.
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“AMP also reversed deficits in various cognitive and motor performances (Magill et al., 2003) and complex expression identification (Huck et al., 2008) following continuous sleep deprivation.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Magill et al., 2003
Citations
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RetractedQUALITATIVE CHARACTERIZATION OF PHYTOCHEMICALS PRESENT IN THE BARK FROM SOME SELECTED TREE SPECIES
Vadera, H. R., Pandya, J., & Mehta, S. (2022) · International Association of Biologicals and Computational Digest · doi:10.56588/iabcd.v1i2.68
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Brands, A., Knauth, K., Mathar, D., Roedder, T., Lisner, K., & Peters, J. (2025) · bioRxiv · doi:10.1371/journal.pcbi.1014356
“TYR supplementation presumably elicits a more indirect manipulation of DA-levels compared to pharmacological approaches [56,2,57,58,7].”
Long, Y., Wang, Z., Hu, X., Wang, S., Zheng, L., Fu, Z., & Ni, Y. (2025) · Metabolites · doi:10.3390/metabo15090577
“In addition, Magill et al. reported that supplementing tyrosine after SD improved working memory, reasoning, and alertness in healthy young men [65].”
Influence de polymorphismes génétiques sur le sommeil et l'efficacité de la caféine
Erblang, M. (2020) · theses.fr (ABES) · doi:10.70675/10d39c5czed91z47dez802cz926b956f3874
Fan, H., Hsieh, C.-C., Chen, T.-P., Lai, P.-J., Hsu, H., Yeh, C., Wu, C. W., Chien, K., Huang, H., & Tung, Y. (2026) · Metabolomics · doi:10.1007/s11306-026-02450-4
“A randomized controlled trial indicated that GABA from unpolished rice improved both subjective and objec-tive sleep quality, (Byun et al., 2018) while tyrosine supplementation enhanced cognitive functions following sleep deprivation (Magill et al., 2003).”
Metadata
- Authors
- Magill, R. A., Waters, W. F., Bray, G. A., Volaufova, J., Smith, S. R., Lieberman, H. R., McNevin, N., & Ryan, D. H.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 6
- Issue
- 4
- Pages
- 237-246
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W1999076139
- Cited by
- 114
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- sleep deprivation, tyrosine, phentermine, caffeine, d-amphetamine, cognitive performance, motor performance, visual vigilance, Stroop task, serial reaction time, long-term memory, amino acid supplementation
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Caffeine, Cognition, Dextroamphetamine, Double-Blind Method, Humans, Male, Motor Activity, Phentermine, Placebos, Sleep Deprivation, Tyrosine
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