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Effects of Tyrosine, Phentermine, Caffeined-amphetamine, and Placebo on Cognitive and Motor Performance Deficits During Sleep Deprivation
Abstract
Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men. Tests of visual scanning, running memory, logical reasoning, mathematical processing, the Stroop task, four-choice serial reaction time, time wall take, pursuit tracking, visual vigilance, Trails (B) task and long-term memory were evaluated at standardized intervals before, during and after sleep deprivation and drugs. Performance decrements with sleep deprivation occurred in visual scanning, running memory, logical reasoning, mathematical processing, the Stroop test, the time wall test, tracking and visual vigilance. Interestingly, with sleep deprivation some tests improved and others did not deteriorate. Improvements with medication following sleep deprivation were seen in running memory, logical reasoning, mathematical processing, tracking and visual vigilance. Although less effective than D-amphetamine, tyrosine improved performance on several tests. We conclude that all drugs tested improved at least some aspects of cognitive and motor performance after sleep deprivation. As a naturally occurring amino acid, and thus amenable to nutritional strategies, tyrosine may deserve further testing.
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“AMP also reversed deficits in various cognitive and motor performances (Magill et al., 2003) and complex expression identification (Huck et al., 2008) following continuous sleep deprivation.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Magill et al., 2003
Citations
Cites
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Aviation, Space, and Environmental Medicine
(2011) · Wilderness and Environmental Medicine · doi:10.1016/j.wem.2010.11.006 · Cited by 1,200
Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine
Wesensten, N. J., Belenky, G. L., Kautz, M. A., Thorne, D. R., Reichardt, R. M., & Balkin, T. J. (2001) · Psychopharmacology · doi:10.1007/s002130100916 · Cited by 404
Hindmarch, I., Rigney, U., Stanley, N., Quinlan, P., Rycroft, J., & Lane, J. (2000) · Psychopharmacology · doi:10.1007/s002130000383 · Cited by 251
Caffeine Eliminates Psychomotor Vigilance Deficits from Sleep Inertia
Dongen, H. P. A. V., Price, N. J., Mullington, J. M., Szuba, M. P., Kapoor, S. C., & Dinges, D. F. (2001) · SLEEP · doi:10.1093/sleep/24.7.813 · Cited by 219
Caffeine reversal of sleep deprivation effects on alertness and mood
Penetar, D. M., McCann, U. D., Thorne, D., Kamimori, G. H., Galinski, C., Sing, H. C., Thomas, M., & Belenky, G. L. (1993) · Psychopharmacology · doi:10.1007/bf02244933 · Cited by 208
Pigeau, R., Naitoh, P., Buguet, A., McCann, C., Baranski, J. V., Taylor, M. M., Thompson, M. M., & MACK, I. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00172.x · Cited by 191
Slow‐release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation
Valck, E. D., & Cluydts, R. (2001) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2001.00260.x · Cited by 140
Beaumont, M., Batéjat, D., Piérard, C., Coste, O., Doireau, P., Beers, P. V., Chauffard, F., Chassard, D., Enslen, M., Denis, J. B., et al. (2001) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2001.00266.x · Cited by 119
The Use of Caffeine Versus Prophylactic Naps in Sustained Performance
Bonnet, M. H., Gomez, S. A., Wirth, O., & Arand, D. L. (1995) · SLEEP · doi:10.1093/sleep/18.2.97 · Cited by 117
Research works printed but not linked: 3
- Dinges D.F., 1992, Sleep, Arousal, and Performance, 176
- Neri D.F., 1995, Aviation Space and Environmental Medicine, 66, 313
- Waters W.F., 2000, Pennington Center Nutrition Series, Volume, 10, Countermeasures for Battlefield Stressors, 290
Cited by
Sorted by citations
A meta-analysis of the impact of short-term sleep deprivation on cognitive variables
Lim, J., & Dinges, D. F. (2010) · Psychological Bulletin · doi:10.1037/a0018883 · Cited by 1,389
“…2005 Falleti et al., 2003 1 Franzen et al., 2008 Frey et al., 2004 Falleti et al., 2003 2 Glenville et al., 1978 Jay et al., 2007 Lee et al., 2003 Magill et al., 2003 McLellan et al., 2007 Pilcher et al., 2007 Roehrs et al 2003 ., Russo et al., 2005 Forest plots for a sample cognitive domain…”
BackgroundMethodInfluentialSleep Deprivation and Vigilant Attention
Lim, J., & Dinges, D. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.002 · Cited by 1,213
Vigilance, alertness, or sustained attention: physiological basis and measurement
Oken, B. S., Salinsky, M. C., & Elsas, S. M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.01.017 · Cited by 887
Allison, D. B., Gadde, K. M., Garvey, W. T., Peterson, C. A., Schwiers, M. L., Najarian, T., Tam, P. Y., Troupin, B., & Day, W. W. (2012) · Obesity · doi:10.1038/oby.2011.330 · Cited by 711
Dopaminergic Modulation of Arousal in Drosophila
Waldowski, R. A., van Swinderen, B., & Greenspan, R. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.025 · Cited by 359
Lieberman, H. R., Bathalon, G. P., Falco, C. M., Kramer, F. M., Morgan, C. A., & Niro, P. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.014 · Cited by 344
Self-citationWESENSTEN, N. J., KILLGORE, W. D. S., & BALKIN, T. J. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00468.x · Cited by 306
“In previous studies, performance-enhancing effects of two of the three compounds have been compared (e.g. caffeine versus dextroamphetamine, Magill et al., 2003; Waters et al., 2003; dextroamphetamine versus modafinil, Pigeau et al., 1995; Saletu et al., 1989; caffeine versus modafinil, Wesensten…”
BackgroundThe Effects of Dietary Nutrition on Sleep and Sleep Disorders
Zhao, M., Tuo, H., Wang, S., & Zhao, L. (2020) · Mediators of Inflammation · doi:10.1155/2020/3142874 · Cited by 301
“reported that supplementation of tyrosine 150mg/kg following overnight sleep deprivation improved working memory, reasoning, and vigilance [73].”
BackgroundInternational Society of Sports Nutrition position stand: energy drinks
Campbell, B. I., Wilborn, C., Bounty, P. L., Taylor, L. W., Nelson, M., Greenwood, M., Ziegenfuss, T. N., Lopez, H. L., Hoffman, J. R., Stout, J. R., et al. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-1 · Cited by 207
“L-Tyrosine Prevents depletion of catecholamines, may ameliorate declines in cognition with acute stress [40-47] Some supportive evidence on cognition (e.”
BackgroundBoot, N. C., Baas, M., van Gaal, S., Cools, R., & Dreu, C. K. W. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.007 · Cited by 198
“Tyrosine counteracts the cognitive effects of sleep deprivation (Magill et al., 2003) and facilitates executive control during a cognitively demanding task (Colzato, Jongkees, Sellaro, & Hommel, 2013).”
Jongkees, B. J., Hommel, B., Kühn, S., & Colzato, L. S. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.08.014 · Cited by 183
“Furthermore, TYR has been beneficial for performance on the Stroop task and working memory while participants were exposed to an auditory stressor (Deijen and Orbleke, 1994), as well as for working memory, reasoning, and vigilance during sleep deprivation (Magill et al., 2003).”
BackgroundThe Effect of Caffeine as an Ergogenic Aid in Anaerobic Exercise
Woolf, K., Bidwell, W. K., & Carlson, A. G. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.4.412 · Cited by 167
“It has also been suggested that caffeine reduces fatigue, improves concentration, and enhances mental alertness (Lieberman, Tharion, Shukitt-Hale, Speckman, & Tulley, 2002; Magill et al., 2003; van Duinen, Lorist, & Zijdewind, 2005).”
BackgroundWinslow, D. H., Bowden, C. H., DiDonato, K. P., & McCullough, P. A. (2012) · Sleep · doi:10.5665/sleep.2204 · Cited by 163
Bonnet, M. H., Balkin, T. J., Dinges, D. F., Roehrs, T., Rogers, N. L., & Wesensten, N. J. (2005) · SLEEP · doi:10.1093/sleep/28.9.1163 · Cited by 164
Cognitive methods for assessing mental energy
Lieberman, H. R. (2007) · Nutritional Neuroscience · doi:10.1080/10284150701722273 · Cited by 118
“1993b), and the scanning visual vigilance test (Fine et al. 1994; Lieberman et al. 1998; Magill et al. 2003).”
BackgroundMethodInfluentialSelf-citationLim, J., Choo, W. C., & Chee, M. W. L. (2007) · SLEEP · doi:10.1093/sleep/30.1.61 · Cited by 115
The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance
Silber, B. Y., Croft, R. J., Papafotiou, K., & Stough, C. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0410-7 · Cited by 140
“Performance on tracking tasks has also been examined with sleep-deprived volunteers (Magill et al. 2003; Belleville et al. 1979), in which a dose of either 10- or 20-mg d-amphetamine significantly improved tracking performance.”
BackgroundTassi, P., Bonnefond, A., Engasser, O., Hoeft, A., Eschenlauer, R., & Muzet, A. G. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.09.017 · Cited by 106
Sleep less, think worse: The effect of sleep deprivation on working memory.
Frenda, S. J., & Fenn, K. M. (2016) · Journal of Applied Research in Memory and Cognition · doi:10.1016/j.jarmac.2016.10.001 · Cited by 121
Pharmacological manipulation of human working memory
Barch, D. M. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1732-3 · Cited by 88
“In addition, several studies have found that amphetamine can ameliorate the deficits in short term/working memory induced by sleep deprivation (e.g. Pigeau et al. 1995; Magill et al. 2003 ).”
Emotional and Cognitive Impact of Sleep Restriction in Children
Vriend, J. L., Davidson, F., Rusak, B., & Corkum, P. V. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.02.009 · Cited by 90
van de Rest, O., van der Zwaluw, N. L., & de Groot, C. P. G. M. (2013) · Amino Acids · doi:10.1007/s00726-013-1583-0 · Cited by 87
Does acute caffeine ingestion alter brain metabolism in young adults?
Xu, F., Liu, P., Pekar, J. J., & Lu, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.046 · Cited by 75
“The primary psychological effects of caffeine are mitigation of drowsiness and improvement in vigilance (Magill et al., 2003).”
Kühn, S., Düzel, S., Colzato, L. S., Norman, K., Gallinat, J., Brandmaier, A. M., Lindenberger, U., & Widaman, K. F. (2017) · Psychological Research · doi:10.1007/s00426-017-0957-4 · Cited by 73
“Even in response to single doses (ranges of 100–300 mg/kg body weight) of tyrosine supplements, effects on cognition have been shown, in particular on working memory performance (Colzato, Jongkees, Sellaro, & Hommel, 2013; Deijen & Orlebeke, 1994; Deijen, Wientjes, Vullinghs, Cloin, & Langefeld, 1999; Magill et al., 2…”
BackgroundLieberman, H. R., Caruso, C. M., Niro, P. J., Adam, G. E., Kellogg, M. D., Nindl, B. C., & Kramer, F. M. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.667 · Cited by 70
Self-citationExecutive dysfunction in major depressive disorder
DeBattista, C. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.1.79 · Cited by 62
Acute effects of dietary constituents on motor skill and cognitive performance in athletes
Baker, L. B., Nuccio, R. P., & Jeukendrup, A. E. (2014) · Nutrition Reviews · doi:10.1111/nure.12157 · Cited by 61
Martindale, S. L., Morissette, S. B., Rowland, J. A., & Dolan, S. L. (2016) · Neuropsychology · doi:10.1037/neu0000312 · Cited by 51
“These results are congruent with previous studies that indicated disturbed sleep impairs these domains of cognitive function (Fernandez-Mendoza et al., 2010; Magill et al., 2003; Verfaellie, Lee, Lafleche, & Spiro, 2015).”
ResultTyrosine prevents effects of hyperthermia on behavior and increases norepinephrine
Lieberman, H. R., Georgelis, J. H., Maher, T. J., & Yeghiayan, S. K. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.10.023 · Cited by 51
Self-citationAparicio, S., Garau, C., Esteban, S., Nicolau, M. C., Rivero, M., & Rial, R. V. (2007) · Nutritional Neuroscience · doi:10.1080/10284150701455916 · Cited by 50
“On the other hand, changes in catecholamine turnover are normally associated with modifications in cognitive and motor functions during waking (Magill et al. 2003) and the absence of changes suggests that the manipulation of dietary tryptophan contents produced no effects on the wake related…”
BackgroundBloemendaal, M., Froböse, M. I., Wegman, J., Zandbelt, B. B., van de Rest, O., Cools, R., & Aarts, E. (2018) · eNeuro · doi:10.1523/eneuro.0035-17.2018 · Cited by 47
“…150 mg/kg body weight, in accordance with most previous studies in young volunteers (Shurtleff et al., 1994; Neri et al., 1995; Thomas et al., 1999; Magill et al., 2003; Mahoney et al., 2007), but see work by Colzato and colleagues for beneficial effects on cognition in young volunteers with much…”
MethodResultInfluentialInfluence of energy drink ingredients on mood and cognitive performance
Childs, E. (2014) · Nutrition Reviews · doi:10.1111/nure.12148 · Cited by 54
Hart, C. L., Haney, M., Nasser, J. A., & Foltin, R. W. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.04.008 · Cited by 48
Positive Effects of Basic Training on Cognitive Performance and Mood of Adult Females
Lieberman, H. R., Karl, J. P., Niro, P. J., Williams, K. W., Farina, E. K., Cable, S. J., & McClung, J. P. (2014) · Human Factors The Journal of the Human Factors and Ergonomics Society · doi:10.1177/0018720813519472 · Cited by 44
“…of the associations observed varies from study to study depending on the specific aspects of mood and performance examined (Childs & de Wit, 2008; Fiedler, 2005; Fogt, Kalns, & Michael, 2010; Lieberman et al., 2005; Lieberman, Tharion, Shukitt-Hale, Speckman, & Tulley, 2002; Magill et al., 2003).”
BackgroundSelf-citationCrawford, C. C., Teo, L., Lafferty, L. A., Drake, A., Bingham, J. J., Gallon, M. D., O’Connell, M. L., Chittum, H. K., Arzola, S. M., & Berry, K. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux007 · Cited by 42
“This review included 1 low-quality study that found a benefit to long-term memory.(42) This contrasts with the 2001 IOM report that cited earlier studies in which caffeine appeared to improve long-term memory.”
MethodResultMorrow, S. A., Smerbeck, A., Patrick, K., Cookfair, D., Weinstock-Guttman, B., & Benedict, R. H. B. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6663-7 · Cited by 40
“Amphetamines also enhance executive function, attention and working memory in patients with schizophrenia [18, 19] and after sleep deprivation [20, 21].”
BackgroundEffects of Amino Acid Derivativeson Physical, Mental, and Physiological Activities
Luckose, F., Pandey, M. C., & Radhakrishna, K. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.708368 · Cited by 40
Sleep Deprivation and Time-Based Prospective Memory
Esposito, M. J., Occhionero, M., & Cicogna, P. (2015) · SLEEP · doi:10.5665/sleep.5172 · Cited by 39
L-tyrosine to alleviate the effects of stress?
Young, S. N. (2007) · PubMed Central · Cited by 36
Observing changes in human functioning during induced sleep deficiency and recovery periods
Ochab, J. K., Jerzy Szwed, A., Oleś, K., Beres, A. M., Chialvo, D. R., Domagalik, A., Fąfrowicz, M., Gudowska-Nowak, E., Marek, T., Nowak, M. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255771 · Cited by 41
Caffeine: Implications for Alertness in Athletes
Rogers, N. L., & Dinges, D. F. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.012 · Cited by 35
Attipoe, S., Zeno, S. A., Lee, C., Crawford, C. C., Khorsan, R., Walter, A. R., & Deuster, P. A. (2015) · Military Medicine · doi:10.7205/milmed-d-14-00594 · Cited by 32
Zhang, X., Zheng, Y., Feng, J., Zhou, R., & Ma, M. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111672 · Cited by 32
Altered amino acid homeostasis in subjects affected by fibromyalgia
Bazzichi, L. M., Palego, L., Giannaccini, G., Rossi, A., Feo, F. D., Giacomelli, C., Betti, L., Giusti, L., Mascia, G., Bombardieri, S., et al. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.02.025 · Cited by 31
“Moreover many studies indicated the use of tyrosine in particular conditions such as stress [38], fatigue [39] and insomnia [40,41].”
BackgroundEffects of caffeine on visual evoked potencial (P300) and neuromotor performance
Deslandes, A. C., Veiga, H., Cagy, M., Piedade, R. A. M., Pompeu, F. A. M. S., & Ribeiro, P. F. M. (2004) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2004000300002 · Cited by 30
Ditta, S. A., Yaqub, A., Tanvir, F., Rashid, M. A. R., Ullah, R., Zubair, M., Ali, S., & Anjum, K. M. (2023) · Journal of Materials Science · doi:10.1007/s10853-023-08209-9 · Cited by 28
Lieberman, H. R., Thompson, L., Caruso, C. M., Niro, P. J., Mahoney, C. R., McClung, J. P., & Caron, G. R. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3727-7 · Cited by 25
“…way reduce the behavioral and physiological consequences of stress (Lehnert et al. 1984a; Lehnert et al. 1984b; Banderet and Lieberman 1989; Shurtleff et al. 1993; Lieberman 1994; Deijen and Orlebeke 1994; Neri et al. 1995; Thomas et al. 1999; Magill et al. 2003; Deijen 2005; Mahoney et al. 2007).”
BackgroundSelf-citationTipper, C. M., Cairo, T. A., Woodward, T. S., Phillips, A. G., Liddle, P. F., & Ngan, E. T. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0025-4 · Cited by 34
“Baranski and Pigeau, 1997; Magill et al. 2003; Shappell et al. 1992).”
BackgroundKennedy, D. O., Wightman, E. L., Forster, J. S., Khan, J., Haskell‐Ramsay, C. F., & Jackson, P. A. (2017) · Nutrients · doi:10.3390/nu9121332 · Cited by 24
Mental Energy: Assessing the Cognition Dimension
Lieberman, H. R. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00252.x · Cited by 21
Self-citationA rodent model of the human psychomotor vigilance test: Performance comparisons
Davis, C. M., Roma, P. G., & Hienz, R. D. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.11.014 · Cited by 22
Montenegro, M., Veiga, H., Deslandes, A. C., Cagy, M., McDowell, K., Pompeu, F. A. M. S., Piedade, R. A. M., & Ribeiro, P. F. M. (2005) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2005000300009 · Cited by 19
Tuell, J. R., Park, J., Wang, W., Cooper, B. R., Sobreira, T. J. P., Cheng, H. W., & Kim, Y. H. B. (2020) · Foods · doi:10.3390/foods9020215 · Cited by 18
Mathar, D., Abdoust, M. E., Tuszus, D., Marrenbach, T., & Peters, J. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010785 · Cited by 21
“(2003) [7] who found that following sleep deprivation, tyrosine significantly reduced RTs compared with placebo across several cognitive tasks.”
BackgroundPaulus, R., Roth, A., Titus, L., Chen, R., Bridges, M. C., & Woodyard, S. (2015) · The Ohio Journal of Science · doi:10.18061/ojs.v115i2.4607 · Cited by 17
Effects of d-amphetamine on simulated driving performance before and after sleep deprivation
Hjälmdahl, M., Vadeby, A., Forsman, Å., Fors, C., Ceder, G., Woxler, P., & Kronstrand, R. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2744-7 · Cited by 16
Crawford, C. C., Boyd, C. C., & Deuster, P. A. (2021) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2021.0135 · Cited by 18
Kwong, A. C., Cassé‐Perrot, C., Costes-Salon, M.-C., Jouve, É., Lanteaume, L., Audebert, C., Rouby, F., Lefebvre, M., Ranjeva, J., Beck, A., et al. (2020) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001199 · Cited by 13
“Previous studies using the N-back task or the RVP task on HV, with or without SD condition, with or without psychoactive drugs, also provided quite heterogeneous results.(15,33,44,45) Indeed, one should be cautious when comparing the results of studies with different designs: the population (eg, military with experien…”
ResultKassim, F. M. (2023) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2856 · Cited by 11
“AMP also reversed deficits in various cognitive and motor performances (Magill et al., 2003) and complex expression identification (Huck et al., 2008) following continuous sleep depri- vation.”
BackgroundContemplating Cognitive Enhancement in Medical Students and Residents
Webb, J., Thomas, J. W., & Valasek, M. A. (2010) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0154 · Cited by 12
Cognitive Function in Ecstasy Naive Abstinent Drug Dependants and MDMA Users
Potter, A., Downey, L. A., & Stough, C. K. K. (2013) · Current Drug Abuse Reviews · doi:10.2174/1874473711306010008 · Cited by 10
“Acute doses of amphetamine have also been found to improve psychomotor performance on measures such as Digit Symbol Substitution [7] and tracking tasks [8].”
MethodMcAllister, M. J., Martaindale, M. H., Dillard, C. C., & McCullough, R. (2024) · Stress · doi:10.1080/10253890.2024.2375588 · Cited by 9
“…1999). however, the most common dose among literature is typically 150 mg/kg (attipoe et al., 2015; Bloemendaal et al., 2018; coull et al., 2015; Magill et al., 2003; Mahoney et al., 2007). as such, the lack of an interaction effect from supplement ingestion on salivary stress markers could be…”
InfluentialTyrosine negatively affects flexible-like behaviour under cognitively demanding conditions
Robson, A., Lim, L. W., & Aquili, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.031 · Cited by 9
Humility Pills: Building an Ethics of Cognitive Enhancement
Goodman, R. (2014) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1093/jmp/jhu017 · Cited by 8
Human Nutritional Neuroscience: Fundamental Issues
Lieberman, H. R. (2005) · doi:10.1201/9780203564554-5 · Cited by 8
Self-citationTumilty, L., Davison, G., Beckmann, M., & Thatcher, R. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2577-4 · Cited by 7
Utility of caffeine: evidence from the laboratory
Bonnet, M. H., & Arand, D. L. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511783005.008 · Cited by 5
Schork, N. J., Baker, D. G., & Risbrough, V. B. (2008) · CRC Press eBooks · doi:10.1201/9781420071788.ch8 · Cited by 5
Lieberman, H. R., Caruso, C. M., Niro, P. J., & Bathalon, G. P. (2006) · Defense Technical Information Center (DTIC) · Cited by 5
Self-citationLieberman, H. R. (2005) · Nutrition, brain, and behavior./Nutrition, brain and behavior · doi:10.1201/9780203564554.pt1 · Cited by 5
Self-citationElectrochemical Quantification of Tyrosine in the Presence of Analogous Amino Acids
Amani‐Beni, Z., & Nezamzadeh‐Ejhieh, A. (2023) · ChemistrySelect · doi:10.1002/slct.202300493 · Cited by 4
The effects of caffeine and d-amphetamine on spatial span task in healthy participants
Kassim, F. M., Lim, J. H. M., Slawik, S. V., Gaus, K., Peters, B., Lee, J. W. Y., Hepple, E. K., Rodger, J., Albrecht, M. A., & Martin-Iverson, M. T. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287538 · Cited by 7
“Several studies have shown that amphetamine improves subjective ratings of arousal and perceived enhancements [5], and objective measures of cognitive performance in sleep-deprived participants [6–11].”
Cheng, C., Xue, X., Jiao, Y., You, R., Zhang, M., Jia, M., Du, M., Zeng, X., Sun, J., Qin, W., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.12.044 · Cited by 4
Dawes, D. M., Ho, J. D., Vincent, A. S., Nystrom, P., & Driver, B. E. (2017) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2017.11.001 · Cited by 4
Effect of sleep restriction on cognitive function and its underlying mechanism
Liu, Q., Ru, T., Luo, X. G., Niu, J., Ma, Y., & Zhou, G. (2020) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2020.01493 · Cited by 5
“…在各复杂任务成绩上, 睡眠 限制与控制条件之间没有显著差异; 而在完成心 理运动警觉性任务时, 睡眠限制条件下被试的任 务表现显著变差, 且随着睡眠限制天数的增加而 持续下降。Sadeh, Gruber 和 Raviv (2003)使用简单 反应时任务和其他复杂认知任务也发现, 睡眠限 制对持续性注意功能的影响较大, 而对其他复杂 认知任务, 如手指敲击任务(运动速度功能)和数 字广度测试(工作记忆功能)等影响较小。同样地, 有研究发现, 与非睡眠限制条件相比, 在睡眠限 制条件下, 被试完成简单反应时任务的反应时显 著增加; 在线索反应时任务中,…”
Effects of regular whey protein consumption on rat thyroid functions
Akkurt, G., Kartal, B., Alimoğulları, M., Çaylı, S., & Alimoğulları, E. (2021) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2010-270 · Cited by 4
“In addition, numerous studies have been conducted on the relationships of tyrosine with stress, fatigue, prolonged sleep disorder, stress induced weight loss, stress induced changes in blood pressure, neuroendocrine system, perceptive, cognitive and physical performance in humans, and stress hormones [26].”
BackgroundBelbis, M. D., Camic, C. L., Howell, S. M., Zhang, S., & Chomentowski, P. J. (2022) · International journal of exercise science · doi:10.70252/uitr3728 · Cited by 5
Mathar, D., Abdoust, M. E., Tuszus, D., Marrenbach, T., & Peters, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.09.479693 · Cited by 4
A Catecholamine Precursor Does Not Influence Exercise Performance in Warm Conditions
Cordery, P., James, L. J., Peirce, N., Maughan, R. J., & Watson, P. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000791 · Cited by 3
“However, some improvements in performance have been observed for L-tyrosine supplementation during long duration military drills (25,32,34).”
BackgroundGijselaers, H. J. M., Kirschner, P. A., & de Groot, R. H. M. (2018) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000278 · Cited by 3
Acute sleep deprivation in humans
Casale, C. E., Brieva, T. E., Yamazaki, E. M., Antler, C. A., & Goel, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00005-0 · Cited by 3
Fields, B. D., Pascal, D. G., Rando, O. K., Huddleston, M., Ingram, K., Hopton, R., Grogg, M. W., Nelson, M., & Voigt, C. A. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00690 · Cited by 2
Mortaz‐Hedjri, S., Nooraie, R. Y., & Akbari-Kamrani, M. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006446 · Cited by 2
RetractedForsan, H. F. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-2681-3_19 · Cited by 2
An Overview of Sports Supplements
Lockwood, C. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-302-8_22 · Cited by 2
Neurotransmitters and Short-Term Effects of Nutrition on Behavior
Nair, K. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-35437-4_5 · Cited by 2
Lieberman, H. R., Carvey, C. E., & Thompson, L. (2010) · CRC Press eBooks · doi:10.1201/b14669-13 · Cited by 2
Self-citationZokaei, N. (2013) · UCL Discovery (University College London) · Cited by 2
Stimulant Reversal of Cognitive Deficits
Wesensten, N. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511783005.007 · Cited by 1
Alternatives for Sustaining Cognitive Performance During Sleep Loss
Wesensten, N. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511783005.015 · Cited by 1
Dietary Protein, Cognitive Decline, and Dementia
van de Rest, O., van der Zwaluw, N. L., & de Groot, C. P. G. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00071-9 · Cited by 1
Nutritional countermeasures for cognitive performance decrements following sleep deprivation
Mahoney, C. R., & Lieberman, H. R. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511783005.016 · Cited by 1
Self-citationStress and Metabolism: The Role of Individual Micronutrients in Correcting Disorders
Никитина, Е. А., Орлова, С. В., Batysheva, T. T., Balashova, N. V., Alekseeva, М. V., Prokopenko, E. V., & Vodolazkaya, A. N. (2024) · Medical alphabet · doi:10.33667/2078-5631-2024-16-31-38 · Cited by 1
Relevant Pharmacology and Interventions
Watson, A., & Hand, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-72862-4_3 · Cited by 1
l -Tyrosine to alleviate the effects of stress?
Young, S. N. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0721 · Cited by 1
Macek, C. C. (2005) · PUB – Publications at Bielefeld University (Bielefeld University) · Cited by 1
Estrogen therapy and the cognitive impairments of sleep deprivation
Regestein, Q. R. (2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200512020-00004 · Cited by 1
Plini, E. R. G., Melnychuk, M. C., Harkin, A., Dahl, M. J., McAuslam, M., Kühn, S., Boyle, R. T., Whelan, R., Andrews, R., Düzel, S., et al. (2023) · Preprints.org · doi:10.20944/preprints202304.0406.v1
Lim, J. (2010) · ScholarlyCommons (University of Pennsylvania)
Military Nutrition Research: Four Tasks to Address Personnel Readiness and Warfighter Performance
Ryan, D. H. (2006) · Defense Technical Information Center (DTIC)
Self-citation
Metadata
- Authors
- Magill, R. A., Waters, W. F., Bray, G. A., Volaufova, J., Smith, S. R., Lieberman, H. R., McNevin, N., & Ryan, D. H.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 6
- Issue
- 4
- Pages
- 237-246
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W1999076139
- Cited by
- 114
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- sleep deprivation, tyrosine, phentermine, caffeine, d-amphetamine, cognitive performance, motor performance, visual vigilance, Stroop task, serial reaction time, long-term memory, amino acid supplementation
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Caffeine, Cognition, Dextroamphetamine, Double-Blind Method, Humans, Male, Motor Activity, Phentermine, Placebos, Sleep Deprivation, Tyrosine
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