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Cited by 122Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorOpioid Use Disorder Treatment

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Pharmacotherapy for Methamphetamine Dependence: A Review of the Pathophysiology of Methamphetamine Addiction and the Theoretical Basis and Efficacy of Pharmacotherapeutic Interventions

Rose, Mark E., Grant, Jon E.·2008·Annals of Clinical Psychiatry
DOI 10.1080/10401230802177656
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Abstract

BACKGROUND: Methamphetamine (METH) dependence is a significant public health, criminal justice, and social service concern, and although abuse of this drug spans the past 40 years in the U.S., effective treatments have only recently been developed and evaluated. Psychosocial therapies comprise the mainstay of treatment, yet many patients experience ongoing impairments in mood, cognition, emotional control, and motivation, suggesting a role for pharmacotherapy. METHODS: A search of the literature was performed to identify drug therapies utilized with METH dependent patients and the outcome of these trials. RESULTS: With the exception of bupropion, most trials employing direct monoamine agonists yielded negative or inclusive results, a counterintuitive finding. Positive results were produced by a trial of the mixed monoamine agonist/antagonist mirtazapine and by several studies employing indirect dopamine- and glutamate-modulating GABA agonists. Most trials were hampered by high rates of subject attrition, mirroring the difficulty in treating these patients in the outpatient setting. CONCLUSIONS: Although considered preliminary, several therapeutic agents were identified that may prove beneficial in treating METH-dependent patients, including bupropion, mirtazapine, baclofen, and topiramate. Psychosocial therapy remains the cornerstone of treatment, and drug therapy should be regarded as an adjunct, rather than a replacement for psychosocial approaches.

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Crossref · 10.1080/10401230802177656

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Metadata

Authors
Rose, M. E., & Grant, J. E.
Affiliations
University of Minnesota (US)
ORCID
Grant, Jon E.
Venue
Annals of Clinical Psychiatry
Publisher
SAGE Publications
Published
2008-08
Volume
20
Issue
3
Pages
145-155
ISSN
  • 1040-1237 (ISSN-L)
  • 1547-3325
DOI
10.1080/10401230802177656
OpenAlex
W2123983203
Cited by
121
References
74
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 42 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
7.14
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
methamphetamine dependence, pharmacotherapy, bupropion, mirtazapine, baclofen, topiramate, GABA agonists, dopaminergic modulation, glutamate modulation, treatment discontinuation, psychosocial interventions, adjunctive therapy
MeSH terms
Amygdala, Central Nervous System Stimulants, Chronic Disease, Humans, Methamphetamine, Nucleus Accumbens, Recurrence, Neurotransmitter Agents, Amphetamine-Related Disorders

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