Cited by 243Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorOpioid Use Disorder Treatment

Pharmacological approaches to methamphetamine dependence: a focused review

Open access
Karila, Laurent, Weinstein, Aviv, Aubin, Henri‐Jean, Benyamina, Amine, Reynaud, Michel, Batki, Steven L.·2010·British Journal of Clinical Pharmacology

Abstract

Methamphetamine dependence is a serious worldwide public health problem with major medical, psychiatric, socioeconomic and legal consequences. Various neuronal mechanisms implicated in methamphetamine dependence have suggested several pharmacological approaches. A literature search from a range of electronic databases (PubMed, EMBASE, PsycInfo, the NIDA research monograph index and the reference list of clinicaltrials.gov) was conducted for the period from January 1985 to October 2009. There were no restrictions on the identification or inclusion of studies in terms of publication status, language and design type. A variety of medications have failed to show efficacy in clinical trials, including a dopamine partial agonist (aripiprazole), GABAergic agents (gabapentin) and serotonergic agents (SSRI, ondansetron, mirtazapine). Three double‐blind placebo‐controlled trials using modafinil, bupropion and naltrexone have shown positive results in reducing amphetamine or methamphetamine use. Two studies employing agonist replacement medications, one with d‐amphetamine and the other with methylphenidate, have also shown promise. Despite the lack of success in most studies to date, increasing efforts are being made to develop medications for the treatment of methamphetamine dependence and several promising agents are targets of further research.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2125.2010.03639.x

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Karila, L., Weinstein, A., Aubin, H., Benyamina, A., Reynaud, M., & Batki, S. L.
Affiliations
  • Inserm (FR)
  • Hadassah Medical Center (IL)
  • San Francisco VA Medical Center (US)
Corresponding author
Karila, Laurent
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2010-05-10
Volume
69
Issue
6
Pages
578-592
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
OpenAlex
W1747110054
Cited by
242
References
135
Citations by year
2026: 8 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 8 · 2019: 13 · 2018: 20 · 2017: 15 · 2016: 18 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 29
FWCI
2.46
Type
journal article
Language
en
Open access
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (U10DA015815, R01DA016764, UG1DA015815)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
methamphetamine dependence, pharmacotherapy, partial dopamine agonist, aripiprazole, GABAergic agents, gabapentin, serotonergic agents, modafinil, bupropion, naltrexone, d-amphetamine, methylphenidate, drug addiction
MeSH terms
Animals, Calcium Channel Blockers, Humans, Immunotherapy, Methamphetamine, Narcotic Antagonists, Antipsychotic Agents, Neurotransmitter Agents, Amphetamine-Related Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review