Review on Characteristics and Analytical Methods of Tazarotene: An Update
Abstract
Tazarotene (TZR) is the first topical receptor-selective retinoid prodrug derived from vitamin A used for management of plaque psoriasis and efficacious in dealing of acne vulgaris, and photo aging. As per US food and drug administration (FDA), 0.1% strength of TZR is permitted for the treatment of acne. This article draws attention to various advanced and conventional analytical methods. The hyphenated and conventional chromatographic techniques such as LC-MS/MS and HPTLC, HPLC respectively. Moreover, spectrophotometric methods like UV/visible spectroscopy also used to quantify TZR as active pharmaceutical ingredient and its formulations, especially in topical preparations. Moreover, the TZR is required alternative methods for routine quality control and to estimate TZR in pharmaceutical dosage form especially in pharmacokinetic studies of topical preparation. This write up focus on critical review of characteristics, uses and the information about the physicochemical, pharmacokinetics properties, mechanisms of action and more emphasis on different analytical methods for estimation of TZR in pharmaceutical formulations.
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Tazarotene and adapalene formulations have high affinity and selectivity for RARβ and RARγ, although tazarotene showed more toxicity than adapalene in dermatological applications.
“Tazarotene and adapalene formulations have high affinity and selectivity for RARβ and RARγ, although the first one showed more toxicity than the second in dermatological applications33.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [33]
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- Authors
- Gaikwad, J., Sharma, S., & Hatware, K. V.
- Affiliations
- Narsee Monjee Institute of Management Studies (IN)
- Corresponding author
- Sharma, Sanjay
- Venue
- Critical Reviews in Analytical Chemistry
- Publisher
- Informa UK Limited
- Published
- 2019-04-03
- Volume
- 50
- Issue
- 1
- Pages
- 90-96
- ISSN
- 1040-8347 (ISSN-L)
- 1547-6510
- OpenAlex
- W2932835115
- Cited by
- 37
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- tazarotene, topical retinoids, plaque psoriasis, acne, photoaging, pharmacokinetics, physicochemical properties, mechanism of action
- MeSH terms
- Administration, Topical, Chromatography, High Pressure Liquid, Drug Compounding, Humans, Nicotinic Acids, Prodrugs, Retinoids, Spectrophotometry, Ultraviolet, Drug Delivery Systems, Tandem Mass Spectrometry, Green Chemistry Technology
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