Cited by 163Natural Antidiabetic Agents StudiesBioactive natural compoundsCarbohydrate Chemistry and Synthesis

α-Glucosidase and α-amylase inhibitors from seed oil: a review of liposoluble substance to treat diabetes

Teng, Hui, Chen, Lei·2017·Critical Reviews in Food Science and Nutrition

Abstract

One of the effective managements of diabetes mellitus, in particular, noninsulin-dependent diabetes mellitus, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as α-glucosidase and α-amylase, in the digestive organs. Currently, there is renewed interest in plant-based medicines and functional foods modulating physiological effects in the inhibition of α-glucosidase and α-amylase. Accordingly, inhibitors of α-glucosidase or α-amylase derived from various sources have also been isolated, and majority of phenolic compounds and their effects have been investigated in animals as well. As such, when the presence of α-glucosidase inhibitor in many foodstuffs was screened for, we found that vegetable seed oil also strongly inhibited α-glucosidase and α-amylase. Seed oil is an important source of liposoluble constituents with potential for inhibition of these enzymes, hence can also be used as therapeutic or functional food sources. Therefore, this review is aimed at highlighting the main liposoluble classes of α-glucosidase and α-amylase inhibitors, but it is not intended to be an exhaustive review on the subject.

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Crossref · 10.1080/10408398.2015.1129309

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  • α-Glucosidase inhibitors prolong overall carbohydrate digestion duration and reduce the rate of glucose absorption.

    “Besides, α-Glucosidase Inhibitors contribute for prolonging the overall carbohydrate digestion duration and reducing the rate of glucose absorption (189).”

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Authors
Teng, H., & Chen, L.
Affiliations
Fujian Agriculture and Forestry University (CN)
Corresponding author
Chen, Lei
Venue
Critical Reviews in Food Science and Nutrition
Published
2017-05-25
Volume
57
Issue
16
Pages
3438-3448
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2276117594
Cited by
162
References
107
Citations by year
2026: 14 · 2025: 19 · 2024: 20 · 2023: 19 · 2022: 22 · 2021: 17 · 2020: 27 · 2019: 13 · 2018: 5 · 2017: 3 · 2016: 3
FWCI
8.35
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords
alpha-glucosidase inhibitors, alpha-amylase inhibitors, seed oil, type 2 diabetes, glucose absorption, carbohydrate hydrolysis, phenolic compounds, functional foods, plant-derived drugs, enzyme inhibition
MeSH terms
alpha-Amylases, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Enzyme Inhibitors, Humans, Intestinal Absorption, Plant Extracts, Glycoside Hydrolase Inhibitors

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