The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies
Abstract
Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process involving multiple organs (liver, kidney, and intestine). Although UA metabolism in the liver and kidneys has been elucidated, only a few studies have focused on the process in the intestine. With our growing knowledge of the effects of gut microorganisms on health, the gut microbiota has been identified as a new target for HUA treatment. In this review, the relationship between HUA and the gut microbiota is elucidated, and anti-hyperuricemia mechanisms targeting the intestine are discussed, such as the promotion of purine and UA catabolism by the gut microbiota, increases in UA excretion by the gut microbiota and its metabolites, regulation of UA absorption or secretion in the intestinal tract by certain transporters, and the intestinal inflammatory response to the gut microbiota. Additionally, probiotics (Bifidobacteria and Lactobacilli) and prebiotics (polyphenols, peptides, and phytochemicals) with UA-lowering effects targeting the intestinal tract are summarized, providing reference and guidance for further research.
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Cites
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Cited by
Hyperuricemia and its related diseases: mechanisms and advances in therapy
Du, L., Zong, Y., Li, H., Wang, Q., Xie, L., Yang, B., Pang, Y., Zhang, C., Zhong, Z., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01916-y · Cited by 631
Metadata
- Authors
- Wang, J., Chen, Y., Zhong, H., Chen, F., Regenstein, J., Hu, X., Cai, L., & Feng, F.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2021-01-22
- Volume
- 62
- Issue
- 14
- Pages
- 3979-3989
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W3146850553
- Cited by
- 317
- References
- 70
- FWCI
- 25.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, J., Chen, Y., Zhong, H., Chen, F., Regenstein, J., Hu, X., Cai, L., & Feng, F. (2022). The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2021.1874287
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