The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases
Abstract
Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars and the free amines of amino acids. The Maillard reaction is related to sensory characteristics in thermal processed food, while AGEs are formed in food matrix in this process. AGEs are a key link between carbonyl stress and neurodegenerative disease. AGEs can interact with receptors for AGEs (RAGE), causing oxidative stress, inflammation response and signal pathways activation related to neurodegenerative diseases. Neurodegenerative diseases are closely related to gut microbiota imbalance and intestinal inflammation. Polyphenols with multiple hydroxyl groups showed a powerful ability to scavenge ROS and capture α-dicarbonyl species, which led to the formation of mono- and di- adducts, thereby inhibiting AGEs formation. Neurodegenerative diseases can be effectively prevented by inhibiting AGEs production, and interaction with RAGEs, or regulating the microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on AGEs inhibition, RAGE-ligand interactions blocking, and regulating the abundance and diversity of gut microbiota, and intestinal inflammation alleviation to delay or prevent neurodegenerative diseases progress. It is a wise and promising strategy to supplement dietary polyphenols for preventing neurodegenerative diseases via AGEs-RAGE axis and microbiota-gut-brain axis regulation.
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“The gut microbiota is an important participant in the bidirectional exchange of information between the gut and the brain, which is described as the microbiota–gut–brain axis [5].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [5]
Citations
Cites
1 retracted
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RetractedCryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 1×
“(v) Controlling the production of neurotransmitters that may enter the blood circulation and cross blood brain barrier (BBB), which mainly included gamma-aminobutyric acid (GABA), acetylcholine, 5-HT and dopamine (Cryan et al. 2019; Kennedy et al. 2017; Morais, Schreiber, and Mazmanian 2021).”
BackgroundHost microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180 · cited 1×
“Therefore, the content of serotonin in the brain can be affected via regulating the amount of serotonin precursor-tryptophan produced by the microbiota (Agus, Planchais, and Sokol 2018).”
BackgroundOxidative Stress: A Key Modulator in Neurodegenerative Diseases
Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2019) · Molecules · doi:10.3390/molecules24081583 · Cited by 2,398
The gut microbiota–brain axis in behaviour and brain disorders
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Cited by
Sorted by citations
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2023) · Nutrients · doi:10.3390/nu15092150 · Cited by 213
Chehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8
Metadata
- Authors
- Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X.
- Affiliations
- Ningbo University (CN)
- Guangzhou University (CN)
- Corresponding author
- Liu, Lianliang
- Yang, Xinquan
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2022-05-19
- Volume
- 63
- Issue
- 29
- Pages
- 9816-9842
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W4280616897
- Cited by
- 156
- References
- 256
- Citations by year
- 2026: 24 · 2025: 42 · 2024: 29 · 2023: 58 · 2022: 3
- FWCI
- 22.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32172210)
- Zhejiang Provincial Natural Science Foundation (LY21C200005)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- dietary polyphenols, advanced glycation end products, RAGE, Maillard reaction, neurodegenerative diseases, gut microbiota, microbiota-gut-brain axis, oxidative stress, intestinal inflammation, AGE formation inhibition, dietary supplementation
- MeSH terms
- Brain-Gut Axis, Humans, Inflammation, Glycation End Products, Advanced, Dietary Supplements, Neurodegenerative Diseases, Polyphenols
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