Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C., Pfander, B., Moldovan, G., Pyrowolakis, G., & Jentsch, S. (2002) · Nature · doi:10.1038/nature00991 · Cited by 2,202 · see citing works

The Transcriptional Program of Sporulation in Budding Yeast

Chu, S., DeRisi, J. L., Eisen, M. B., Mulholland, J., Botstein, D., Brown, P. O., & Herskowitz, I. (1998) · Science · doi:10.1126/science.282.5389.699 · Cited by 1,860 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292 · see citing works

Regulation of DNA repair throughout the cell cycle

Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228 · see citing works

A constant rate of spontaneous mutation in DNA-based microbes.

Drake, J. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7160 · Cited by 1,199 · see citing works

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

Maga, G., & Hübscher, U. (2003) · Journal of Cell Science · doi:10.1242/jcs.00653 · Cited by 1,100 · see citing works

Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation

Rupp, W. D., & Howard-flanders, P. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90445-2 · Cited by 1,093 · see citing works

EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 999 · see citing works

The Y-Family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

Stelter, P., & Ulrich, H. D. (2003) · Nature · doi:10.1038/nature01965 · Cited by 849 · see citing works

Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA

Kannouche, P. L., Wing, J., & Lehmann, A. R. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00259-x · Cited by 845 · see citing works

DNA Replication Fidelity

Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754 · see citing works

Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη

Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736 · see citing works

<i>hRAD30</i> Mutations in the Variant Form of Xeroderma Pigmentosum

Johnson, R. E., Kondratick, C. M., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.285.5425.263 · Cited by 732 · see citing works

Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes

Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727 · see citing works

Repair of Endogenous DNA Damage

LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714 · see citing works

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., et al. (2005) · Science · doi:10.1126/science.1120615 · Cited by 712 · see citing works

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Science · doi:10.1126/science.272.5268.1646 · Cited by 654 · see citing works

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

Mutation as a Stress Response and the Regulation of Evolvability

Galhardo, R. S., Hastings, P. J., & Rosenberg, S. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648502 · Cited by 643 · see citing works

Crystal Structure of a Y-Family DNA Polymerase in Action

Ling, H., Boudsocq, F., Woodgate, R., & Yang, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00515-3 · Cited by 610 · see citing works

Regulation of monoubiquitinated PCNA by DUB autocleavage

Huang, T. T., Nijman, S. M. B., Mirchandani, K. D., Galardy, P. J., Cohn, M. A., Haas, W., Gygi, S. P., Ploegh, H. L., Bernards, R., & D’Andrea, A. D. (2006) · Nature Cell Biology · doi:10.1038/ncb1378 · Cited by 585 · see citing works

Deoxycytidyl transferase activity of yeast REV1 protein

Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Nature · doi:10.1038/382729a0 · Cited by 573 · see citing works

Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

Kato, T., & Shinoura, Y. (1977) · Molecular and General Genetics MGG · doi:10.1007/bf00283484 · Cited by 569 · see citing works

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 538 · see citing works

Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

Watanabe, K., Tateishi, S., Kawasuji, M., Tsurimoto, T., Inoue, H., & Yamaizumi, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600383 · Cited by 538 · see citing works

DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli.

Kenyon, C. J., & Walker, G. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2819 · Cited by 537 · see citing works

Stress-Induced Mutagenesis in Bacteria

Foster, P. L. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648494 · Cited by 536 · see citing works

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

Callebaut, I., & Mornon, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01312-9 · Cited by 524 · see citing works

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.Preprint

Burns, N. A., Grimwade, B. G., Ross‐Macdonald, P., Choi, E. Y., Finberg, K. E., Roeder, G. S., & Snyder, M. P. (1994) · Genes & Development · doi:10.1101/gad.8.9.1087 · Cited by 490 · see citing works

The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis

Wagner, J. E., Grúz, P., Kim, S.-R., Yamada, M., Matsui, K., Fuchs, R. P., & Nohmi, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80376-7 · Cited by 474 · see citing works

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

Friedberg, E. C., Wagner, R., & Radman, M. (2002) · Science · doi:10.1126/science.1070236 · Cited by 443 · see citing works

Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434 · see citing works

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

Edgar, B. A., & Lehner, C. F. (1996) · Science · doi:10.1126/science.274.5293.1646 · Cited by 389 · see citing works

Translesion synthesis: Y-family polymerases and the polymerase switch

LEHMANN, A., NIIMI, A., OGI, T., BROWN, S., SABBIONEDA, S., WING, J., KANNOUCHE, P., & GREEN, C. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.003 · Cited by 389 · see citing works

What a difference a decade makes: Insights into translesion DNA synthesis

Yang, W., & Woodgate, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704219104 · Cited by 377 · see citing works

Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?

Friedberg, E. C., Lehmann, A. R., & Fuchs, R. P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.032 · Cited by 376 · see citing works

Low fidelity DNA synthesis by human DNA polymerase-η

Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372 · see citing works

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

Guo, C., Fischhaber, P. L., Luk‐Paszyc, M. J., Masuda, Y., Zhou, J., Kamiya, K., Kisker, C., & Friedberg, E. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg626 · Cited by 355 · see citing works

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 349 · see citing works

Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sitesPreprint

Haracska, L., Unk, I., Johnson, R. E., Johansson, E., Burgers, P., Prakash, S., & Prakash, L. (2001) · Genes & Development · doi:10.1101/gad.882301 · Cited by 347 · see citing works

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

Trincão, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L., & Aggarwal, A. K. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00306-9 · Cited by 344 · see citing works

Polymerases and the Replisome: Machines within Machines

Baker, T. A., & Bell, S. P. (1998) · Cell · doi:10.1016/s0092-8674(00)80923-x · Cited by 344 · see citing works

Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

Prakash, S., & Prakash, L. (2002) · Genes &amp; Development · doi:10.1101/gad.1009802 · Cited by 344 · see citing works

Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.

Kim, S.-R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., & Ohmori, H. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13792 · Cited by 343 · see citing works

MUTANTS OF YEAST DEFECTIVE IN MUTATION INDUCED BY ULTRAVIOLET LIGHT

Lemontt, J. F. (1971) · Genetics · doi:10.1093/genetics/68.1.21 · Cited by 325 · see citing works

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.Preprint

Bailly, V., Lamb, J., Sung, P., Prakash, S., & Prakash, L. (1994) · Genes & Development · doi:10.1101/gad.8.7.811 · Cited by 321 · see citing works

Replication fork reactivation downstream of a blocked nascent leading strand

Heller, R. C., & Marians, K. J. (2006) · Nature · doi:10.1038/nature04329 · Cited by 318 · see citing works

The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism

McDonald, J. P., Levine, A. S., & Woodgate, R. (1997) · Genetics · doi:10.1093/genetics/147.4.1557 · Cited by 314 · see citing works

Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

Nair, D. T., Johnson, R. E., Prakash, S., Prakash, L., & Aggarwal, A. K. (2004) · Nature · doi:10.1038/nature02692 · Cited by 309 · see citing works

Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

McIlwraith, M. J., Vaisman, A., Liu, Y., Fanning, E., Woodgate, R., & West, S. C. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.001 · Cited by 306 · see citing works

The Fanconi Anaemia Gene FANCC Promotes Homologous Recombination and Error-Prone DNA Repair

Niedźwiedź, W., Mosedale, G., Johnson, M. A., Ong, C. Y., Pace, P., & Patel, K. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.009 · Cited by 306 · see citing works

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ

Gibbs, P., McGregor, W. G., Maher, V. M., Nisson, P. E., & Lawrence, C. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6876 · Cited by 301 · see citing works

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

Bailly, V., Lauder, S., Prakash, S., & Prakash, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23360 · Cited by 292 · see citing works

Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cellsPreprint

Kannouche, P., Broughton, B. C., Volker, M., Hanaoka, F., Mullenders, L. H. F., & Lehmann, A. R. (2001) · Genes & Development · doi:10.1101/gad.187501 · Cited by 278 · see citing works

REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

Morrison, A., Christensen, R. B., Alley, J., Beck, A. K., Bernstine, E. G., Lemontt, J. F., & Lawrence, C. W. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.10.5659-5667.1989 · Cited by 271 · see citing works

Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon.

Burgers, P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54625-1 · Cited by 265 · see citing works

A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates

Jarosz, D. F., Godoy, V. G., Delaney, J. C., Essigmann, J. M., & Walker, G. C. (2006) · Nature · doi:10.1038/nature04318 · Cited by 262 · see citing works

Interaction of hREV1 with three human Y‐family DNA polymerases

Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., & Ohmori, H. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00747.x · Cited by 257 · see citing works

Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2005) · Science · doi:10.1126/science.1116336 · Cited by 249 · see citing works

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., & Kunkel, T. A. (2004) · Nature · doi:10.1038/nature02352 · Cited by 246 · see citing works

PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40

Edmunds, C. E., Simpson, L. J., & Sale, J. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.024 · Cited by 239 · see citing works

Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases η and REV1

Garg, P., & Burgers, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505949102 · Cited by 236 · see citing works

Physical and Functional Interactions of Human DNA Polymerase η with PCNA

Haracska, L., Johnson, R. E., Unk, I., Phillips, B., Hurwitz, J., Prakash, L., & Prakash, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7199-7206.2001 · Cited by 235 · see citing works

Dual Roles for DNA Polymerase η in Homologous DNA Recombination and Translesion DNA Synthesis

Kawamoto, T., Araki, K., Sonoda, E., Yamashita, Y. M., Harada, K. H., Kikuchi, K., Masutani, C., Hanaoka, F., Nozaki, K., Hashimoto, N., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.016 · Cited by 231 · see citing works

Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7

Murakumo, Y., Ogura, Y., Ishii, H., Numata, S., Ichihara, M., Croce, C. M., Fishel, R. A., & Takahashi, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102051200 · Cited by 230 · see citing works

Polκ protects mammalian cells against the lethal and mutagenic effects of benzo[ a ]pyrene

Ogi, T., Shinkai, Y., Tanaka, K., & Ohmori, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222377899 · Cited by 229 · see citing works

Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene

Ohashi, E., Bębenek, K., Matsuda, T., Feaver, W. J., Gerlach, V. L., Friedberg, E. C., Ohmori, H., & Kunkel, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005309200 · Cited by 225 · see citing works

Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass

Lone, S., Townson, S. A., Uljon, S., Johnson, R. E., Brahma, A., Nair, D. T., Prakash, S., Prakash, L., & Aggarwal, A. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.018 · Cited by 225 · see citing works

Replication of a cis–syn thymine dimer at atomic resolution

Ling, H., Boudsocq, F., Plosky, B. S., Woodgate, R., & Yang, W. (2003) · Nature · doi:10.1038/nature01919 · Cited by 216 · see citing works

REV1 Protein Interacts with PCNA: Significance of the REV1 BRCT Domain In Vitro and In Vivo

Guo, C., Sonoda, E., Tang, T.-S., Parker, J. L., Bielen, A. B., Takeda, S., Ulrich, H. D., & Friedberg, E. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.038 · Cited by 213 · see citing works

Efficient Translesion Replication Past Oxaliplatin and Cisplatin GpG Adducts by Human DNA Polymerase η

Vaisman, A., Masutani, C., Hanaoka, F., & Chaney, S. G. (2000) · Biochemistry · doi:10.1021/bi000130k · Cited by 212 · see citing works

The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair

Ogi, T., & Lehmann, A. R. (2006) · Nature Cell Biology · doi:10.1038/ncb1417 · Cited by 211 · see citing works

Interactions between BRCT repeats and phosphoproteins: tangled up in two

Glover, J. N. M., Williams, R. S., & Lee, M. S. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.09.010 · Cited by 211 · see citing works

The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair

Aravind, L., & Koonin, E. V. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01257-2 · Cited by 208 · see citing works

A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage

Albertella, M. R., Green, C., Lehmann, A. R., & O’Connor, M. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1095 · Cited by 208 · see citing works

Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REVl protein

Tissier, A., Kannouche, P. L., Reck, M.-P., Lehmann, A. R., Fuchs, R. P., & Cordonnier, A. M. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.015 · Cited by 207 · see citing works

Evidence for a second function forSaccharomyces cerevisiaeRev1p

Nelson, J. R., Gibbs, P., Nowicka, A., Hinkle, D. C., & Lawrence, C. W. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01997.x · Cited by 205 · see citing works

Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA

Andersen, P. L., Xu, F., & Xiao, W. (2007) · Cell Research · doi:10.1038/cr.2007.114 · Cited by 204 · see citing works

Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase η

Alt, A., Lammens, K., Chiocchini, C., Lammens, A., Pieck, J. C., Kuch, D., Hopfner, K., & Carell, T. (2007) · Science · doi:10.1126/science.1148242 · Cited by 204 · see citing works

Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

Tissier, A., Frank, E. G., McDonald, J. P., Iwai, S., Hanaoka, F., & Woodgate, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.19.5259 · Cited by 202 · see citing works

DNA polymerase zeta (pol ζ) in higher eukaryotes

Gan, G. N., Wittschieben, J. P., Wittschieben, B. Ø., & Wood, R. D. (2007) · Cell Research · doi:10.1038/cr.2007.117 · Cited by 202 · see citing works

Cellular roles of DNA polymerase ζ and Rev1 protein

Lawrence, C. W. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00038-1 · Cited by 202 · see citing works

Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

Zhou, B.-L., Pata, J. D., & Steitz, T. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00310-0 · Cited by 198 · see citing works

Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

Haracska, L., Kondratick, C. M., Unk, I., Prakash, S., & Prakash, L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00319-7 · Cited by 198 · see citing works

Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage

Guo, C., Tang, T.-S., Bienko, M., Parker, J. L., Bielen, A. B., Sonoda, E., Takeda, S., Ulrich, H. D., Đikić, I., & Friedberg, E. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01118-06 · Cited by 198 · see citing works

A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiae

Holbeck, S. L., & Strathern, J. N. (1997) · Genetics · doi:10.1093/genetics/147.3.1017 · Cited by 198 · see citing works

Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin

Plosky, B. S., Vidal, A. E., de Henestrosa, A. R. F., McLenigan, M. P., McDonald, J. P., Mead, S., & Woodgate, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601178 · Cited by 196 · see citing works

A Sliding-Clamp Toolbelt Binds High- and Low-Fidelity DNA Polymerases Simultaneously

Indiani, C., McInerney, P., Georgescu, R. E., Goodman, M. F., & O’Donnell, M. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.011 · Cited by 194 · see citing works

Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

Haracska, L., Johnson, R. E., Unk, I., Phillips, B. B., Hurwitz, J., Prakash, L., & Prakash, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261560798 · Cited by 193 · see citing works

Localization of DNA polymerases η and ι to the replication machinery is tightly co‐ordinated in human cells

Kannouche, P. L., de Henestrosa, A. R. F., Coull, B. J., Vidal, A. E., Gray, C., Zicha, D., Woodgate, R., & Lehmann, A. R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf618 · Cited by 190 · see citing works

Error-prone lesion bypass by human DNA polymerase eta

Zhang, Y. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.23.4717 · Cited by 188 · see citing works

Prokaryotic DNA polymerase I: evolution, structure, and “base flipping” mechanism for nucleotide selection

Patel, P. H., Suzuki, M., Adman, E. T., Shinkai, A., & Loeb, L. A. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4619 · Cited by 185 · see citing works

The X family portrait: Structural insights into biological functions of X family polymerases

Moon, A. F., García–Díaz, M., Batra, V. K., Beard, W. A., Bębenek, K., Kunkel, T. A., Wilson, S. H., & Pedersen, L. C. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.05.009 · Cited by 185 · see citing works

Novel Human and Mouse Homologs of Saccharomyces cerevisiae DNA Polymerase η

McDonald, J. P., Rapić-Otrin, V., Epstein, J. A., Broughton, B. C., Wang, X., Lehmann, A. R., Wolgemuth, D. J., & Woodgate, R. (1999) · Genomics · doi:10.1006/geno.1999.5906 · Cited by 183 · see citing works

Fission Yeast Eso1p Is Required for Establishing Sister Chromatid Cohesion during S Phase

Tanaka, K., Yonekawa, T., Kawasaki, Y., Kai, M., Furuya, K., Iwasaki, M., Murakami, H., Yanagida, M., & Okayama, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3459-3469.2000 · Cited by 182 · see citing works

The human DINB1 gene encodes the DNA polymerase Polθ

Johnson, R. E., Prakash, S., & Prakash, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.3838 · Cited by 182 · see citing works

Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

Washington, M. T., Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36835 · Cited by 181 · see citing works

A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2

Murakumo, Y., Roth, T., Ishii, H., Rasio, D., Numata, S., Croce, C. M., & Fishel, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4391 · Cited by 181 · see citing works

The human REV1 gene codes for a DNA template-dependent dCMP transferase

Lin, W., Xin, H., Zhang, Y., Wu, X., Yuan, F., & Wang, Z. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.22.4468 · Cited by 180 · see citing works

The Relative Roles in Vivo of Saccharomyces cerevisiae Pol η, Pol ζ, Rev1 Protein and Pol32 in the Bypass and Mutation Induction of an Abasic Site, T-T (6-4) Photoadduct and T-T cis-syn Cyclobutane Dimer

Gibbs, P., McDonald, J. P., Woodgate, R., & Lawrence, C. W. (2004) · Genetics · doi:10.1534/genetics.104.034611 · Cited by 180 · see citing works

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

Silvian, L. F., Toth, E. A., Pham, P., Goodman, M. F., & Ellenberger, T. E. (2001) · Nature Structural Biology · doi:10.1038/nsb1101-984 · Cited by 179 · see citing works

Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells

Avkin, S., Goldsmith, M., Velasco-Miguel, S., Geacintov, N. E., Friedberg, E. C., & Livneh, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409155200 · Cited by 177 · see citing works

Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA

Haracska, L., Unk, I., Johnson, R. E., Phillips, B. B., Hurwitz, J., Prakash, L., & Prakash, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.3.784-791.2002 · Cited by 177 · see citing works

The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

Gibbs, P., Wang, X.-D., Li, Z., McManus, T. P., McGregor, W. G., Lawrence, C. W., & Maher, V. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4186 · Cited by 175 · see citing works

Crystal structure of a benzo[ a ]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

Ling, H., Sayer, J. M., Plosky, B. S., Yagi, H., Boudsocq, F., Woodgate, R., Jerina, D. M., & Yang, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308332100 · Cited by 175 · see citing works

Disruption of the developmentally regulated Rev3l gene causes embryonic lethality

Wittschieben, J. P., Shivji, M. K. K., Lalani, E., Jacobs, M. A., Marini, F., Gearhart, P. J., Rosewell, I. R., Stamp, G., & Wood, R. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00725-9 · Cited by 173 · see citing works

129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

McDonald, J. P., Frank, E. G., Plosky, B. S., Rogozin, I. B., Masutani, C., Hanaoka, F., Woodgate, R., & Gearhart, P. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030767 · Cited by 172 · see citing works

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G 2 /M phase rather than S phase

Waters, L. S., & Walker, G. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510167103 · Cited by 171 · see citing works

Gaps and forks in DNA replication: rediscovering old models

Lehmann, A. R., & Fuchs, R. P. (2006) · DNA Repair · doi:10.1016/j.dnarep.2006.07.002 · Cited by 170 · see citing works

A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling

Iwai, H., Kim, M., Yoshikawa, Y., Ashida, H., Ogawa, M., Fujita, Y., Muller, D., Kirikae, T., Jackson, P. K., Kotani, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.06.043 · Cited by 169 · see citing works

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

Niimi, A., Brown, S. E., Sabbioneda, S., Kannouche, P. L., Scott, A., Yasui, A., Green, C., & Lehmann, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802727105 · Cited by 166 · see citing works

DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.

Lawrence, C. W., & Hinkle, D. C. (1996) · PubMed · Cited by 166 · see citing works

Nucleotide excision repair and cancer

Leibeling, D., Laspe, P., & Emmert, S. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9041-x · Cited by 164 · see citing works

Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV‐induced DNA breaks

Garinis, G. A., Mitchell, J. R., Moorhouse, M. J., Hanada, K., de Waard, H., Vandeputte, D., Jans, J. J. M., Brand, K., Smid, M., van der Spek, P. J., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600849 · Cited by 163 · see citing works

Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

Esposito, G., Godin, I., Klein, U., Yaspo, M., Cumano, A., & Rajewsky, K. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00726-0 · Cited by 161 · see citing works

Checkpoint activation regulates mutagenic translesion synthesisPreprint

Kai, M., & Wang, T. S. ‐. (2003) · Genes & Development · doi:10.1101/gad.1043203 · Cited by 158 · see citing works

The Saccharomyces cerevisiae RAD6 Group Is Composed of an Error-Prone and Two Error-Free Postreplication Repair Pathways

Xiao, W., Chow, B. L., Broomfield, S., & Hanna, M. D. (2000) · Genetics · doi:10.1093/genetics/155.4.1633 · Cited by 155 · see citing works

Damage repair DNA polymerases Y

Yang, W. (2003) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00003-9 · Cited by 153 · see citing works

Low-fidelity DNA synthesis by human DNA polymerase theta

Arana, M. E., Seki, M., Wood, R. D., Rogozin, I. B., & Kunkel, T. A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn310 · Cited by 153 · see citing works

Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro

Bemark, M., Khamlichi, A. A., Davies, S. L., & Neuberger, M. S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00724-7 · Cited by 149 · see citing works

Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae

Rasmussen, A. K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg446 · Cited by 149 · see citing works

Specificity of DNA Lesion Bypass by the Yeast DNA Polymerase η

Yuan, F., Zhang, Y., Rajpal, D. K., Wu, X., Guo, D., Wang, M., Taylor, J., & Wang, Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8233 · Cited by 146 · see citing works

Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk

Sakiyama, T., Kohno, T., Mimaki, S., Ohta, T., Yanagitani, N., Sobue, T., Kunitoh, H., Saito, R., Shimizu, K., Hirama, C., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20790 · Cited by 146 · see citing works

The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis

Larimer, F. W., Perry, J. R., & Hardigree, A. A. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.1.230-237.1989 · Cited by 145 · see citing works

Efficient and accurate bypass of N 2 -(1-carboxyethyl)-2′-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

Yuan, B., Cao, H., Jiang, Y., Hong, H., & Wang, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711546105 · Cited by 144 · see citing works

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1

Ross, A.-L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki279 · Cited by 144 · see citing works

MAD2B is an inhibitor of the anaphase-promoting complexPreprint

Chen, J., & Fang, G. (2001) · Genes & Development · doi:10.1101/gad.898701 · Cited by 144 · see citing works

Replication of damaged DNA by translesion synthesis in human cells

Lehmann, A. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.029 · Cited by 142 · see citing works

Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion

Zhang, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.7.1630 · Cited by 141 · see citing works

Fidelity of Escherichia coli DNA Polymerase IV

Kobayashi, S., Valentine, M. R., Pham, P., O’Donnell, M. E., & Goodman, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204826200 · Cited by 141 · see citing works

Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein DinB

Ogi, T., Kato, T., Kato, T., & Ohmori, H. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00289.x · Cited by 141 · see citing works

DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint

Bi, X., Slater, D., Ohmori, H., & Vaziri, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501562200 · Cited by 140 · see citing works

Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1Preprint

Pfleger, C. M., Salic, A. N., Lee, E. N., & Kirschner, M. W. (2001) · Genes & Development · doi:10.1101/gad.897901 · Cited by 140 · see citing works

Investigating the Role of the Little Finger Domain of Y-family DNA Polymerases in Low Fidelity Synthesis and Translesion Replication

Boudsocq, F., Kokoska, R. J., Plosky, B. S., Vaisman, A., Ling, H., Kunkel, T. A., Yang, W., & Woodgate, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405249200 · Cited by 139 · see citing works

Replication past O 6 -Methylguanine by Yeast and Human DNA Polymerase η

Haracska, L., Prakash, S., & Prakash, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8001-8007.2000 · Cited by 139 · see citing works

Cellular Functions of DNA Polymerase ζ and Rev1 Protein

Lawrence, C. W. (2004) · Advances in protein chemistry · doi:10.1016/s0065-3233(04)69006-1 · Cited by 137 · see citing works

Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

Haracska, L., Unk, I., Prakash, L., & Prakash, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510924103 · Cited by 136 · see citing works

Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability

Roush, A. A., Suarez, M., Friedberg, E. C., Radman, M., & Siede, W. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050698 · Cited by 135 · see citing works

The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 Genes Are Required for Tolerating Irreparable, Ultraviolet-Induced DNA Damage

Paulovich, A. G., Armour, C. D., & Hartwell, L. H. (1998) · Genetics · doi:10.1093/genetics/150.1.75 · Cited by 133 · see citing works

Defining the position of the switches between replicative and bypass DNA polymerases

藤井, 慎., & Fuchs, R. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600438 · Cited by 133 · see citing works

Translesion Synthesis by Human DNA Polymerase η across Thymine Glycol Lesions

Kusumoto, R., Masutani, C., Iwai, S., & Hanaoka, F. (2002) · Biochemistry · doi:10.1021/bi025549k · Cited by 132 · see citing works

Complex Formation with Rev1 Enhances the Proficiency of Saccharomyces cerevisiae DNA Polymerase ζ for Mismatch Extension and for Extension Opposite from DNA Lesions

Acharya, N., Johnson, R. E., Prakash, S., & Prakash, L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01671-06 · Cited by 128 · see citing works

Ubiquitination of PCNA and the Polymerase Switch in Human Cells

Kannouche, P. L., & Lehmann, A. R. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1074 · Cited by 127 · see citing works

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

Stary, A., Kannouche, P. L., Lehmann, A. R., & Sarasin, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211838200 · Cited by 127 · see citing works

p53 and p21 Regulate Error-Prone DNA Repair to Yield a Lower Mutation Load

Avkin, S., Sevilya, Z., Toube, L., Geacintov, N. E., Chaney, S. G., Oren, M., & Livneh, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.022 · Cited by 124 · see citing works

The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins

Zhong, X., Garg, P., Stith, C. M. W., McElhinny, S. A. N., Kissling, G. E., Burgers, P., & Kunkel, T. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl465 · Cited by 124 · see citing works

Human DNA Polymerase ι Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2005) · Structure · doi:10.1016/j.str.2005.08.010 · Cited by 123 · see citing works

Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

Washington, M. T., Prakash, L., & Prakash, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00613-4 · Cited by 123 · see citing works

A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic Agents

Chen, Y., Cleaver, J. E., Hanaoka, F., Chang, C., & Chou, K.-M. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0118 · Cited by 122 · see citing works

Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

Zhuang, Z., Johnson, R. E., Haracska, L., Prakash, L., Prakash, S., & Benkovic, S. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801310105 · Cited by 121 · see citing works

UmuD and RecA Directly Modulate the Mutagenic Potential of the Y Family DNA Polymerase DinB

Godoy, V. G., Jarosz, D. F., Simon, S. M., Abyzov, A. S., Ilyin, V., & Walker, G. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.025 · Cited by 121 · see citing works

DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.

O‐Wang, J., Kawamura, K., Tada, Y., Ohmori, H., Kimura, H., Sakiyama, S., & Tagawa, M. (2001) · PubMed · Cited by 121 · see citing works

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., & Kunkel, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152126799 · Cited by 120 · see citing works

Evidence that in Xeroderma Pigmentosum Variant Cells, which Lack DNA Polymerase η, DNA Polymerase ι Causes the Very High Frequency and Unique Spectrum of UV-Induced Mutations

Wang, Y., Woodgate, R., McManus, T. P., Mead, S., McCormick, J. J., & Maher, V. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3073 · Cited by 120 · see citing works

REV7, a new gene concerned with UV mutagenesis in yeast

Lawrence, C. W., Das, G., & Christensen, R. B. (1985) · Molecular and General Genetics MGG · doi:10.1007/bf00383316 · Cited by 118 · see citing works

The 9-1-1 Checkpoint Clamp Physically Interacts with Polζ and Is Partially Required for Spontaneous Polζ-dependent Mutagenesis in Saccharomyces cerevisiae

Sabbioneda, S., Minesinger, B. K., Giannattasio, M., Plevani, P., Muzi-Falconi, M., & Jinks-Robertson, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507638200 · Cited by 118 · see citing works

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Jin, Y., Chen, Z., Liu, Y., Hickey, R. J., & Malkas, L. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0603 · Cited by 117 · see citing works

The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo

Lenne‐Samuel, N., Wagner, J. E., Etienne, H., & Fuchs, R. P. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf007 · Cited by 116 · see citing works

A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with Ubiquitinated Proliferating Cell Nuclear Antigen in Response to DNA Damage

Wood, A., Garg, P., & Burgers, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702366200 · Cited by 116 · see citing works

Increased Catalytic Activity and Altered Fidelity of Human DNA Polymerase ι in the Presence of Manganese

Frank, E. G., & Woodgate, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702159200 · Cited by 115 · see citing works

Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase IV

Fiala, K. A., & Suo, Z. (2004) · Biochemistry · doi:10.1021/bi035746z · Cited by 114 · see citing works

Crystal Structure of the Catalytic Core of Human DNA Polymerase Kappa

Uljon, S., Johnson, R. E., Edwards, T. A., Prakash, S., Prakash, L., & Aggarwal, A. K. (2004) · Structure · doi:10.1016/j.str.2004.05.011 · Cited by 114 · see citing works

Multiple Roles of Vertebrate REV Genes in DNA Repair and Recombination

Okada, T., Sonoda, E., Yoshimura, M., Kawano, Y., Saya, H., Kohzaki, M., & Takeda, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6103-6111.2005 · Cited by 112 · see citing works

Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

Plosky, B. S., & Woodgate, R. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.002 · Cited by 111 · see citing works

UV-B Radiation Induces Epithelial Tumors in Mice Lacking DNA Polymerase η and Mesenchymal Tumors in Mice Deficient for DNA Polymerase ι

Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01076-06 · Cited by 111 · see citing works

Inefficient Bypass of an Abasic Site by DNA Polymerase η

Haracska, L., Washington, M. T., Prakash, S., & Prakash, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008021200 · Cited by 110 · see citing works

Human DNA polymerase iota protects cells against oxidative stress

Lajus, T. B. P., Nakajima, S., Zlatanou, A., Despras, E., Couvé, S., Ishchenko, A. A., Sarasin, A. R., Yasui, A., & Kannouche, P. L. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.210 · Cited by 108 · see citing works

Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

Dumstorf, C. A., Clark, A. B., Lin, Q., Kissling, G. E., Yuan, T., Kucherlapati, R., McGregor, W. G., & Kunkel, T. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605247103 · Cited by 106 · see citing works

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase in Saccharomyces cerevisiae

Parker, J. L., Bielen, A. B., Đikić, I., & Ulrich, H. D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1102 · Cited by 104 · see citing works

The Roles of REV3 and RAD57 in Double-Strand-Break-Repair-Induced Mutagenesis of Saccharomyces cerevisiae

Rattray, A. J., Shafer, B. K., McGill, C. B., & Strathern, J. N. (2002) · Genetics · doi:10.1093/genetics/162.3.1063 · Cited by 101 · see citing works

Properties and Functions of Escherichia Coli: Pol IV and Pol V

Fuchs, R. P., Fujii, S., & Wagner, J. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69008-5 · Cited by 100 · see citing works

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

Soria, G., Podhajcer, O. L., Prives, C. L., & Gottifredi, V. (2005) · Oncogene · doi:10.1038/sj.onc.1209315 · Cited by 100 · see citing works

Efficient and Error-Free Replication past a Minor-Groove N2-Guanine Adduct by the Sequential Action of Yeast Rev1 and DNA Polymerase ζ

Washington, M. T., Minko, I. G., Johnson, R. E., Haracska, L., Harris, T. M., Lloyd, R. S., Prakash, S., & Prakash, L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.6900-6906.2004 · Cited by 98 · see citing works

A novel function of DNA polymerase ζ regulated by PCNA

Northam, M. R., Garg, P., Baitin, D., Burgers, P., & Shcherbakova, P. V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601320 · Cited by 98 · see citing works

Polymerase η deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

Limoli, C. L., Giedzinski, E., Morgan, W. F., & Cleaver, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130182897 · Cited by 98 · see citing works

Pol32, a Subunit of Saccharomyces cerevisiae DNA Polymerase δ, Suppresses Genomic Deletions and Is Involved in the Mutagenic Bypass Pathway

Huang, M., Rio, A.-G., Galibert, M., & Galibert, F. (2002) · Genetics · doi:10.1093/genetics/160.4.1409 · Cited by 98 · see citing works

REV3 and REV1 Play Major Roles in Recombination-independent Repair of DNA Interstrand Cross-links Mediated by Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA)

Shen, X. H., Jun, S., O'Neal, L. E., Sonoda, E., Bemark, M., Sale, J. E., & Li, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600071200 · Cited by 97 · see citing works

Enzymatic switching for efficient and accurate translesion DNA replication.

McCulloch, S. D., Kokoska, R., Chilkova, O., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh777 · Cited by 97 · see citing works

Addendum

Kannouche, P. L., de Henestrosa, A. R. F., Coull, B. J., Vidal, A. E., Gray, C., Zicha, D., Woodgate, R., & Lehmann, A. R. (2003) · The EMBO Journal · doi:10.1093/emboj/7595006 · Cited by 96 · see citing works

Role of DNA polymerases η, ι and ζ in UV resistance and UV-induced mutagenesis in a human cell line

Guéranger, Q., Stary, A., Aoufouchi, S., Faili, A., Sarasin, A. R., Reynaud, C., & Weill, J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.05.012 · Cited by 95 · see citing works

Yeast DNA polymerase zeta (ζ) is essential for error-free replication past thymine glycolPreprint

Johnson, R. E., Yu, S., Prakash, S., & Prakash, L. (2003) · Genes & Development · doi:10.1101/gad.1048303 · Cited by 95 · see citing works

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

Soria, G., Speroni, J., Podhajcer, O. L., Prives, C., & Gottifredi, V. (2008) · Journal of Cell Science · doi:10.1242/jcs.027730 · Cited by 94 · see citing works

Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase ζ

Garg, P., Stith, C. M. W., Majka, J., & Burgers, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500173200 · Cited by 93 · see citing works

The RAD6 Pathway: Control of DNA Damage Bypass and Mutagenesis by Ubiquitin and SUMO

Ulrich, H. D. (2005) · ChemBioChem · doi:10.1002/cbic.200500139 · Cited by 93 · see citing works

Portraits of a Y‐family DNA polymerase

Yang, W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.047 · Cited by 92 · see citing works

Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

Bavoux, C., Leopoldino, A. M., Bergoglio, V., Wang, J. O., Ogi, T., Bieth, A., Judde, J., Pena, S. D. J., Poupon, M., Helleday, T., et al. (2005) · PubMed · Cited by 92 · see citing works

Inactivation of Human MAD2B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents

Cheung, H. W., Chun, A. C. S., Wang, Q., Deng, W., Hu, L., Guan, X., Nicholls, J. M., Ling, M., Wong, Y. C., Tsao, S. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3602 · Cited by 91 · see citing works

Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι

Vidal, A. E., Kannouche, P. L., Podust, V. N., Yang, W., Lehmann, A. R., & Woodgate, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406511200 · Cited by 90 · see citing works

Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage

Sloun, P. P. H. V., Varlet, I., Sonneveld, E., Boei, J. J. W. A., Romeijn, R. J., Eeken, J. C. J., & de Wind, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2159-2169.2002 · Cited by 89 · see citing works

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

Mirchandani, K. D., McCaffrey, R. M., & D’Andrea, A. D. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.001 · Cited by 88 · see citing works

Complex Formation of Yeast Rev1 and Rev7 Proteins: a Novel Role for the Polymerase-Associated Domain

Acharya, N., Haracska, L., Johnson, R. E., Unk, I., Prakash, S., & Prakash, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9734-9740.2005 · Cited by 88 · see citing works

Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase

Yamada, A., Masutani, C., Iwai, S., & Hanaoka, F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2473 · Cited by 87 · see citing works

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

Jansen, J. G. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki189 · Cited by 85 · see citing works

Glycogen Synthase Kinase 3β Phosphorylates p21WAF1/CIP1 for Proteasomal Degradation after UV Irradiation

Lee, J. Y., Yu, S., Park, Y. G., Kim, J., & Sohn, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01461-06 · Cited by 85 · see citing works

Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells

Avkin, S., & Livneh, Z. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00254-3 · Cited by 84 · see citing works

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Taliun, D., Harris, D. N., Kessler, M. D., Carlson, J., Szpiech, Z. A., Torres, R., Taliun, S. A. G., Corvelo, A., Gogarten, S. M., Kang, H. M., et al. (2021) · Nature · doi:10.1038/s41586-021-03205-y · Cited by 2,213 · see citing works

DNA polymerases and cancer

Lange, S. S., Takata, K.-I., & Wood, R. D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2998 · Cited by 615 · see citing works

Mechanisms of trinucleotide repeat instability during human development

McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496 · see citing works

The role of DNA damage and repair in aging through the prism of Koch-like criteria

Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N., & Moldovan, G.-L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.020 · Cited by 325 · see citing works

Translesion DNA Polymerases

Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317 · see citing works

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

Sale, J. E. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012708 · Cited by 282 · see citing works

Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy

Doles, J., Oliver, T. G., Cameron, E. R., Hsu, G., Jacks, T., Walker, G. C., & Hemann, M. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011409107 · Cited by 190 · see citing works

USP7: Structure, substrate specificity, and inhibition

Pozhidaeva, A., & Bezsonova, I. (2019) · DNA Repair · doi:10.1016/j.dnarep.2019.02.005 · Cited by 178 · see citing works

Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies

Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication

Punchihewa, C., Inoue, A., Hishiki, A., Fujikawa, Y., Connelly, M., Evison, B., Shao, Y., Heath, R., Kuraoka, I., Rodrigues, P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.353201 · Cited by 135 · see citing works

Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

Walmacq, C., Cheung, A. C. M., Kireeva, M. L., Lubkowska, L., Ye, C., Gotte, D., Strathern, J. N., Carell, T., Cramer, P., & Kashlev, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.006 · Cited by 124 · see citing works

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

Mansilla, S. F., De La Vega, M. B., Calzetta, N. L., Siri, S. O., & Gottifredi, V. (2020) · Genes · doi:10.3390/genes11060593 · Cited by 114 · see citing works

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Yamanaka, K., Chatterjee, N., Hemann, M. T., & Walker, G. C. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006842 · Cited by 87 · see citing works

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

Korzhnev, D. M., & Hadden, M. K. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00596 · Cited by 58 · see citing works

G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets

Estep, K. N., Butler, T. J., Ding, J., & Brosh, R. M. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867324666171116123345 · Cited by 58 · see citing works

Postreplication gaps at UV lesions are signals for checkpoint activation

Callegari, A. J., Clark, E., Pneuman, A., & Kelly, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003449107 · Cited by 54 · see citing works

Control of DNA Damage Bypass by Ubiquitylation of PCNA

Ripley, B. M., Gildenberg, M. S., & Washington, M. T. (2020) · Genes · doi:10.3390/genes11020138 · Cited by 48 · see citing works

Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction

Sail, V., Rizzo, A. A., Chatterjee, N., Dash, R. C., Ozen, Z., Walker, G. C., Korzhnev, D. M., & Hadden, M. K. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01144 · Cited by 52 · see citing works

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome

Temviriyanukul, P., van Hees-Stuivenberg, S., Delbos, F., Jacobs, H., de Wind, N., & Jansen, J. G. (2012) · DNA Repair · doi:10.1016/j.dnarep.2012.03.007 · Cited by 41 · see citing works

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication

Ning, K., Kuz, C. A., Cheng, F., Feng, Z., Yan, Z., & Qiu, J. (2023) · mBio · doi:10.1128/mbio.03528-22 · Cited by 33 · see citing works

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Yamanaka, K., Dorjsuren, D., Eoff, R. L., Egli, M., Maloney, D. J., Jadhav, A., Simeonov, A., & Lloyd, R. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045032 · Cited by 35 · see citing works

The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight

Bertolin, A. P., Mansilla, S. F., & Gottifredi, V. (2015) · DNA Repair · doi:10.1016/j.dnarep.2015.04.027 · Cited by 30 · see citing works

Persistently stalled replication forks inhibit nucleotide excision repair in <i>trans</i> by sequestering Replication protein A

Tsaalbi-Shtylik, A., Moser, J., Mullenders, L. H. F., Jansen, J. G., & de Wind, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1412 · Cited by 28 · see citing works

Characterization of a New Murine Cellular DNA Polymerase

Livingston, D. M., Serxner, L. E., Howk, D. J. D., et al. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.57 · Cited by 22 · see citing works

Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases α and β

Eckert, K. A., & Hile, S. E. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00206-1 · Cited by 11 · see citing works

Serological Analysis of the Deoxyribonucleic Acid Polymerase of Avian Oncornaviruses II. Comparison of Avian Deoxyribonucleic Acid Polymerases

Nowinski, R. C., Watson, K. F., Yaniv, A., & Spiegelman, S. (1972) · Journal of Virology · doi:10.1128/jvi.10.5.959-964.1972 · Cited by 52 · see citing works

8-OxodGTP Incorporation by DNA Polymerase β Is Modified by Active-Site Residue Asn279

Miller, H., Prasad, R., Wilson, S. H., Johnson, F., & Grollman, A. P. (2000) · Biochemistry · doi:10.1021/bi991789x · Cited by 104 · see citing works

Properties of DNA polymerases from young and ageing human fibroblasts

Murray, V. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90017-8 · Cited by 31 · see citing works