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Cited by 61Lymphoma Diagnosis and TreatmentCNS Lymphoma Diagnosis and TreatmentViral-associated cancers and disorders

Adrenal involvement in non-Hodgkin’s lymphoma: four cases and review of literature

Singh, Devinder, Kumar, Lalit, Sharma, Atul, Vijayaraghavan, M, Thulkar, Sanjay, Tandon, N·2004·Leukemia & Lymphoma
DOI 10.1080/10428190310001615756
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Abstract

Primary adrenal non-Hodgkin's lymphoma is very rare. We have seen 2 such cases among 241 cases of non-Hodgkin's lymphoma (0.83%) over the past 4 years. We could detect 2 more cases who had adrenal involvement, in addition to other extra nodal disease sites. Review of English literature revealed 65 cases of primary adrenal non-Hodgkin's lymphoma, most being single case reports. Salient features included-median age of 68 years (mean age of 47.25 years in our series), bilateral adrenal involvement in 60%, and predominantly diffuse large cell histology with 'B' cell immunophenotype. Adrenal insufficiency was present in two-thirds of the patients at diagnosis. Chemotherapy with or without radiotherapy is the mainstay of treatment. About half the patients respond to treatment, with median survival of 4 months. The high index of suspicion for early diagnosis and prompt treatment may improve outcome.

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Crossref · 10.1080/10428190310001615756

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Primary adrenal lymphoma accounts for less than 1% of all cases of non-Hodgkin lymphoma.

    “Conversely primary adrenal lymphoma is much rarer accounting for <1% of all cases of non-Hodgkin lymphoma (183).”

    From Adrenal incidentaloma (2020) · cites this paper as [183]

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  • Adrenal incidentaloma

    Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works

    “Conversely primary adrenal lymphoma is much rarer accounting for 1% of all cases of non-Hodgkin lymphoma (183).”
    Background

Related

Authors
Singh, D., Kumar, L., Sharma, A., Vijayaraghavan, M., Thulkar, S., & Tandon, N.
Affiliations
DR. B.R.A. Institute Rotary Cancer Hospital (IN)
Corresponding author
Singh, Devinder
ORCID
Venue
Leukemia & Lymphoma
Publisher
Informa UK Limited
Published
2004-04
Volume
45
Issue
4
Pages
789-794
ISSN
  • 1026-8022 (ISSN-L)
  • 1042-8194
  • 1029-2403
DOI
10.1080/10428190310001615756
OpenAlex
W2123608504
Cited by
61
References
57
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 5
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Locations
  • Leukemia & lymphoma/Leukemia and lymphoma (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Neurology › CNS Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
adrenal lymphoma, extranodal lymphoma, bilateral adrenal involvement, diffuse large cell lymphoma, B-cell immunophenotype, adrenal insufficiency, chemotherapy, radiotherapy, survival
MeSH terms
Adrenal Gland Neoplasms, Adult, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Female, Humans, Lymphoma, Non-Hodgkin, Male, Middle Aged, Tomography, X-Ray Computed, Salvage Therapy, Treatment Outcome

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