Arterial thrombosis in four patients treated with thalidomide
Abstract
Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.
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The increased risk seen with concomitant use of corticosteroids such as dexamethasone and chemotherapeutic agents such as anthracyclines raises the possibility of thrombosis secondary to endothelial cell injury.
“The increased risk seen with concomitant use of corticosteroids, such as dexamethasone, and chemotherapeutic agents, such as anthracyclines, raises the possibility of thrombosis secondary to endothelial cell injury133.”
From Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide (2021) · cites this paper as [133]
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Kristinsson, S. Y., Pfeiffer, R. M., Björkholm, M., Goldin, L. R., Schulman, S., Blimark, C., Mellqvist, U.-H., Wahlin, A., Turesson, I., & Landgren, O. (2010) · Blood · doi:10.1182/blood-2009-11-252072 · Cited by 255 · see citing works
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
Jan, M., Sperling, A. S., & Ebert, B. L. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00479-z · Cited by 137 · see citing works
- Authors
- Scarpace, S., Hahn, T., Roy, H., Brown, K., Paplham, P., Chanan-Khan, A., van Besien, K., & McCarthy, Jr.
- Affiliations
- Albany College of Pharmacy and Health Sciences (US)
- Roswell Park Comprehensive Cancer Center (US)
- Venue
- Leukemia & Lymphoma
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 46
- Issue
- 2
- Pages
- 239-242
- ISSN
- 1026-8022 (ISSN-L)
- 1042-8194
- 1029-2403
- OpenAlex
- W2059311525
- Cited by
- 50
- References
- 13
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 4 · 2018: 1 · 2017: 2 · 2016: 4 · 2014: 1 · 2012: 2
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia & lymphoma/Leukemia and lymphoma (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- thalidomide, arterial thrombosis, venous thrombosis, lymphoma, multiple myeloma, aspirin, warfarin, anticoagulation, adverse drug reactions, drug safety
- MeSH terms
- Aged, Arterial Occlusive Diseases, Aspirin, Drug Therapy, Combination, Female, Humans, Lymphoma, Male, Middle Aged, Multiple Myeloma, Thalidomide, Thrombosis, Warfarin, Intracranial Thrombosis
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