Psychosocial characteristics of patients undergoing cellular immunotherapies and their caregivers across time
Open accessAbstract
Chimeric antigen receptor T-cells and other immunotherapies have markedly changed the paradigm of treatment for patients with relapsed or refractory hematologic malignancies. While notable in efficacy, immunotherapy is characterized by a significant possibility of life-threatening side effects. Consequently, patients are often required to have informal family caregivers present and to stay near the treating center for several weeks after cell infusion. Further, the responsibility of managing a great deal of physical care and emotional support falls to these caregivers. Given the novelty of immunotherapy treatment, there is a need to better understand the psychosocial experience of patients receiving this treatment and their caregivers. This article describes the psychosocial characteristics of patients undergoing cellular immunotherapies and their caregivers across time, including patient/caregiver distress, coping, and caregiver burden and preparedness.
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Quantitative studies have shown that 15% of family caregivers of patients receiving CAR-T-cell therapy experience moderate to severe burdens, and 47.7% exhibit symptoms of depression.
“Quantitative studies have shown that 15% of family caregivers of patients receiving CAR-T-cell therapy experience moderate to severe burdens, and 47.7% exhibit symptoms of depression.”
From The burdens, coping strategies, and unmet needs of family caregivers of Chinese patients with lymphoma receiving commercial CAR-T-cell therapy: A qualitative study (2026) · cites this paper as [27]
The Results report caregiver burden and depression among people receiving cellular immunotherapies, but give mean scores rather than the claimed percentages. They describe average caregiver burden as mild and do not report that 15% had moderate-to-severe burden or that 47.7% had depressive symptoms. (LLM, conf=0.86)
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- Authors
- Kirtane, K., Reblin, M., Oswald, L. B., Irizarry-Arroyo, N., McCormick, R., Locke, F. L., & Ketcher, D.
- Affiliations
- Moffitt Cancer Center (US)
- University of Vermont (US)
- University of Minnesota (US)
- Corresponding author
- Kirtane, Kedar
- ORCID
- Venue
- Leukemia & Lymphoma
- Publisher
- Informa UK Limited
- Published
- 2022-11-23
- Volume
- 64
- Issue
- 2
- Pages
- 364-370
- ISSN
- 1026-8022 (ISSN-L)
- 1042-8194
- 1029-2403
- PMC
- PMC10329860
- OpenAlex
- W4309830166
- Cited by
- 6
- References
- 33
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Leukemia & lymphoma/Leukemia and lymphoma (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- ECOG-ACRIN (5UG1CA189828-07)
- Federal Award (UG1CA189828)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Health Sciences › Health Professions › Pharmacy › Nursing care and research
- Keywords
- CAR T-cell therapy, cellular immunotherapy, socio-psychological factors, caregivers, caregiver burden, caregiver preparedness, patient distress, coping, relapsed or refractory hematologic malignancies, time course
- MeSH terms
- Adaptation, Psychological, Humans, Immunotherapy, Quality of Life, Caregivers, Hematologic Neoplasms
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