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Cited by 489

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Retention in medication-assisted treatment for opiate dependence: A systematic review

Open access
Timko, Christine, Schultz, Nicole R., Cucciare, Michael A., Vittorio, Lisa, Garrison-Diehn, Christina·2016·Journal of Addictive Diseases

Abstract

Retention in medication-assisted treatment among opiate-dependent patients is associated with better outcomes. This systematic review (55 articles, 2010-2014) found wide variability in retention rates (i.e., 19%-94% at 3-month, 46%-92% at 4-month, 3%-88% at 6-month, and 37%-91% at 12-month follow-ups in randomized controlled trials), and identified medication and behavioral therapy factors associated with retention. As expected, patients who received naltrexone or buprenorphine had better retention rates than patients who received a placebo or no medication. Consistent with prior research, methadone was associated with better retention than buprenorphine/naloxone. And, heroin-assisted treatment was associated with better retention than methadone among treatment-refractory patients. Only a single study examined retention in medication-assisted treatment for longer than 1 year, and studies of behavioral therapies may have lacked statistical power; thus, studies with longer-term follow-ups and larger samples are needed. Contingency management showed promise to increase retention, but other behavioral therapies to increase retention, such as supervision of medication consumption, or additional counseling, education, or support, failed to find differences between intervention and control conditions. Promising behavioral therapies to increase retention have yet to be identified.

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Metadata

Authors
Timko, C., Schultz, N. R., Cucciare, M. A., Vittorio, L., & Garrison-Diehn, C.
Venue
Journal of Addictive Diseases
Published
2015-10-14
Volume
35
Issue
1
Pages
22-35
ISSN
  • 1055-0887 (ISSN-L)
  • 1545-0848
OpenAlex
W2248705888
Cited by
489
References
86
FWCI
2.73
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Retention in medication-assisted treatment for opiate dependence: A systematic review. https://app.cochat.ai/papers/10.1080/10550887.2016.1100960
The paper
Timko, C., Schultz, N. R., Cucciare, M. A., Vittorio, L., & Garrison-Diehn, C. (2016). Retention in medication-assisted treatment for opiate dependence: A systematic review. Journal of Addictive Diseases. https://doi.org/10.1080/10550887.2016.1100960

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.