The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
Abstract
PURPOSE: The blood-brain barrier (BBB) presents both a physical and electrostatic barrier to limit brain permeation of therapeutics. Previous work has demonstrated that nanoparticles (NPs) overcome the physical barrier, but there is little known regarding the effect of NP surface charge on BBB function. Therefore, this work evaluated: (1) effect of neutral, anionic and cationic charged NPs on BBB integrity and (2) NP brain permeability. METHODS: Emulsifying wax NPs were prepared from warm oil-in-water microemulsion precursors using neutral, anionic or cationic surfactants to provide the corresponding NP surface charge. NPs were characterized by particle size and zeta potential. BBB integrity and NP brain permeability were evaluated by in situ rat brain perfusion. RESULTS: Neutral NPs and low concentrations of anionic NPs were found to have no effect on BBB integrity, whereas, high concentrations of anionic NPs and cationic NPs disrupted the BBB. The brain uptake rates of anionic NPs at lower concentrations were superior to neutral or cationic formulations at the same concentrations. CONCLUSIONS: (1) Neutral NPs and low concentration anionic NPs can be utilized as colloidal drug carriers to brain, (2) cationic NPs have an immediate toxic effect at the BBB and (3) NP surface charges must be considered for toxicity and brain distribution profiles.
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Citations
Cites
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
Lockman, P. R., Mumper, R. J., Khan, M. A., & Allen, D. D. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120001481 · Cited by 592
Self-citation
Cited by
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Jiang, J., Oberdörster, G., & Biswas, P. (2009) · Journal of Nanoparticle Research · doi:10.1007/s11051-008-9446-4 · Cited by 1,713
Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609
Metadata
- Authors
- Lockman, P. R., Koziara, J. M., Mumper, R. J., & Allen, D. D.
- Venue
- Journal of Drug Targeting
- Publisher
- Informa UK Limited
- Published
- 2004-12
- Volume
- 12
- Issue
- 9-10
- Pages
- 635-641
- ISSN
- 1026-7158 (ISSN-L)
- 1061-186X
- 1029-2330
- OpenAlex
- W2020915539
- Cited by
- 742
- References
- 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lockman, P. R., Koziara, J. M., Mumper, R. J., & Allen, D. D. (2004). Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability. Journal of Drug Targeting. https://doi.org/10.1080/10611860400015936
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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