The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain
Abstract
Adriamycin (ADR) is a chemotherapeutic agent useful in treating various cancers. ADR is a quinone-containing anthracycline chemotherapeutic and is known to produce reactive oxygen species (ROS) in heart. Application of this drug can have serious side effects in various tissues, including brain, apart from the known cardiotoxic side effects, which limit the successful use of this drug in treatment of cancer. Neurons treated with ADR demonstrate significant protein oxidation and lipid peroxidation. Patients under treatment with this drug often complain of forgetfulness, lack of concentration, dizziness (collectively called somnolence or sometimes called chemobrain). In this study, we tested the hypothesis that ADR induces oxidative stress in brain. Accordingly, we examined the in vivo levels of brain protein oxidation and lipid peroxidation induced by i.p. injection of ADR. We also measured levels of the multidrug resistance-associated protein (MRP1) in brain isolated from ADR- or saline-injected mice. MRP1 mediates ATP-dependent export of cytotoxic organic anions, glutathione S-conjugates and sulphates. The current results demonstrated a significant increase in levels of protein oxidation and lipid peroxidation and increased expression of MRP1 in brain isolated from mice, 72 h post i.p injection of ADR. These results are discussed with reference to potential use of this redox cycling chemotheraputic agent in the treatement of cancer and its chemobrain side effect in brain.
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Cites
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
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“Reactive oxygen species (ROS) leads to protein oxidation [2,3], lipid peroxidation [4,5], DNA and RNA oxidation in brain [6] with concomitant neuronal dysfunction and death.”
BackgroundSelf-citationCastegna, A., Aksenov, M., Aksenova, M., Thongboonkerd, V., Klein, J. B., Pierce, W. M., Booze, R., Markesbery, W. R., & Butterfield, D. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00914-0 · Cited by 581
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“Free radical scavengers are known to reduce this effect [19].”
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Evaluation of the use of therapeutic peptides for cancer treatment
Marqus, S., Pirogova, E., & Piva, T. J. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0328-x · Cited by 512
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Butterfield, D. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.006 · Cited by 126
Self-citationManganese superoxide dismutase: Beyond life and death
Holley, A. K., Dhar, S. K., Xu, Y., & St. Clair, D. K. (2012) · Amino Acids · doi:10.1007/s00726-010-0600-9 · Cited by 122
Self-citationRen, X., Keeney, J. T. R., Miriyala, S., Noel, T., Powell, D. K., Chaiswing, L., Bondada, S., St. Clair, D. K., & Butterfield, D. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.029 · Cited by 88
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Metadata
- Authors
- Joshi, G., Sultana, R., Tangpong, J., Cole, M. P., St Clair, D. K., Vore, M., Estus, S., & Butterfield, D. A.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 39
- Issue
- 11
- Pages
- 1147-1154
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W1985363254
- Cited by
- 184
- References
- 5
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Joshi, G., Sultana, R., Tangpong, J., Cole, M. P., St Clair, D. K., Vore, M., Estus, S., & Butterfield, D. A. (2005). Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain. Free Radical Research. https://doi.org/10.1080/10715760500143478
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