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Extracellular Vesicles and Cancer Therapy: Insights into the Role of Oxidative Stress

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Chemotherapy-induced cognitive impairment and glia: A new take on chemobrain?

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Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis

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Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment

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Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus

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Anthocyanins from purple sweet potato alleviate doxorubicin‐induced cardiotoxicity in vitro and in vivo

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Ranolazine alleviated cardiac/brain dysfunction in doxorubicin-treated rats

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Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations

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Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward

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Inhibition of NLRP3 alleviated chemotherapy-induced cognitive impairment in rats

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Methotrexate Neurotoxicity Is Related to Epigenetic Modification of the Myelination Process

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Chemotherapy-induced cognitive impairment: Mechanisms, emerging biomarkers, and therapeutic interventions

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Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice

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More than a small adult brain: Lessons from chemotherapy-induced cognitive impairment for modelling paediatric brain disorders

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Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway

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Protective Effect of HMG-CoA Reductase Inhibitor Rosuvastatin on Doxorubicin-Induced Cognitive Impairment, Oxidative Stress and Neuroinflammation: Possible Role of CREB, ERK1/2, and BDNF

Yeni, Y., Çiçek, B., Hacımüftüoğlu, A., Özkaraca, M., & Lacın, B. B. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10213-6 · Cited by 15 · see citing works

Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice

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Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

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Complex Interplay between DNA Damage and Autophagy in Disease and Therapy

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New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo

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Breast‐to‐brain metastasis is exacerbated with chemotherapy through blood–cerebrospinal fluid barrier and induces Alzheimer's‐like pathology

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Sex, senescence, senolytics, and cognition

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Manool, a diterpene from Salvia officinalis , exerts preventive effects on chromosomal damage and preneoplastic lesions

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Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

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Wnt3a/GSK3β/β-catenin Signalling Modulates Doxorubicin-associated Memory Deficits in Breast Cancer

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Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example

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The Promise of Nutrient-Derived Bioactive Compounds and Dietary Components to Ameliorate Symptoms of Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

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Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways

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Antipsychotics inhibit the mitochondrial bioenergetics of pancreatic beta cells isolated from CD1 mice

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Epirubicin Treatment Induces Neurobehavioral, Oxido-Inflammatory and Neurohistology Alterations in Rats: Protective Effect of the Endogenous Metabolite of Tryptophan − 3-Indolepropionic Acid

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Mechanistic insights and therapeutic interventions of mitochondrial quality control in chemotherapy-related cognitive impairment

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Chemobrain: An accelerated aging process linking adenosine A2A receptor signaling in cancer survivors

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Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial

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Comparative Neurotoxic Effects of Doxorubicin and Sunitinib: An In Vitro Study on Human Dopaminergic Neuronal Cells

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A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment

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A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer

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Multimodal Cancer Therapy and Accelerated Brain Aging: Mechanisms, Biomarkers, and Clinical Consequences

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Neuroimaging advances in chemotherapy-related cognitive impairment: from clinical to preclinical research

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Triaptosis and Cancer: Next Hope?

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Chemobrain in Cancer Treatment: Mechanisms and Its Prevention

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Mechanisms of chemotherapy-related cognitive impairment

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Effect of l-Dopa in acute temozolomide-induced cognitive impairment in male mice: a possible antineuroinflammatory role

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Extracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage

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The PI3K-AKT-VEGF Signaling Pathway Contributes to Doxorubicin-induced Chemotherapy-related Cognitive Impairment

Zhang, X.-C., Jiang, L.-C., Song, J.-X., Peng, J., Ni, K., Shen, F., & Zhou, C. (2026) · Current Neuropharmacology · doi:10.2174/011570159x414493251121073748 · Cited by 1 · see citing works

STUDIES OF OXIDATIVE DAMAGE, BRAIN PROTEOME, AND NEUROCHEMICAL METABOLITES IN COGNITIVE AND NEURODEGENERATIVE DISORDERS

Ren, X. (2020) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2020.024

The APOE4 Mouse as a Model of Chemotherapy-induced Cognitive Impairments and Senescence

Demby, T. C. (2021) · DigitalGeorgetown (Georgetown University Library)

Chemobrain

Costa, V. M., Dias-Carvalho, A., Capela, J. P., & Carvalho, F. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85215-9.00049-0

Dietary zinc protects against methotrexate-induced neurotoxicity in rats via modulation of oxidative stress, inflammation and neuronal energy metabolismPreprint

Onaolapo, A. Y., Okunola, O. B., Olofinnade, A. T., & Onaolapo, O. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538169

Chemo brain: myth or clinical reality? Literature review and clinical case

Yakhin, K. K., Zagretdinova, D. T., & Sergienko, K. S. (2024) · Neurology Bulletin · doi:10.17816/nb635304

Polyvalent immunoglobulin therapy: preclinical evidence and potential for treating chemotherapy-induced peripheral neuropathy

Moret, W., Danigo, A., Frachet, S., Sturtz, F. G., Bourthoumieu, S., Magy, L., Demiot, C., & Rovini, A. M. F. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2522075

Chemobrain in Cancer Treatment: Mechanisms and Its Prevention

Ongnok, B., Thiankhaw, K., Chattipakorn, N., & Chattipakorn, S. C. (2025) · Springer eBooks · doi:10.1007/978-3-032-00775-9_352

Stimulation of TRPM2 Channel in Glioblastoma Tumour Cells by Gallic Acid Potentiated the Anti-Tumour and Oxidant Effects of Doxorubicin

Yazğan, Y., Yazğan, B., & Ahlatci, A. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700977

Exploration of the mechanism of chemobrain related to neuroinflammation from 1994 to 2023

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Effectiveness and Safety of Acupuncture for Cancer-Related Cognitive Impairment: A Systematic Review and Meta-Analysis

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Dusp22 deficiency in cardiomyocytes exacerbates doxorubicin-induced cardiotoxicity by aggravating mitochondria-dependent apoptosis via JNK pathway

Xiao, M., Liao, B., Zhou, B., Wen, S., Hu, Y., & Li, Z. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168256

Novel Cardiometabolic Factors Regulate Neurite Outgrowth in Cancer Chemotherapy-Induced CardiotoxicityPreprint

Sloan, O., Orr, S., & Rajagopalan, V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.12.731794

Attenuation of DOX‐Associated Biochemical and Histological Brain Alterations

Abdelhiee, E. Y., Fadl, S. E., Elsayed, F., Soliman, A. M., Aboubakr, M., Altalhi, R., Anajirih, N., Majrashi, M., Algahtani, M., Abdel‐Daim, M. M., et al. (2026) · Veterinary Medicine and Science · doi:10.1002/vms3.71161

Intranasal bFGF‑Els alleviate doxorubicin‑induced cognitive deficits in mice by modulating the PI3K/AKT pathway and suppressing oxidative stress, neuroinflammation, and apoptosis

Zhang, M., He, W.-Y., Ma, W.-C., & Yu, S.-F. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106983

Targeting Dectin-1/Syk axis alleviates chemotherapy-induced cognitive impairment via STING signaling pathway

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The triangle of death of neurons, oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules, in brains of mice treated with doxorubicin: advanced insights into mechanisms of “chemobrain”

Butterfield, D. A., Ren, X., Keeney, J. T. R., Bondada, S., & Clair, D. K. S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.129

STUDIES OF OXIDATIVE DAMAGE, BRAIN PROTEOME, AND NEUROCHEMICAL METABOLITES IN COGNITIVE AND NEURODEGENERATIVE DISORDERS

Ren, X. (2020) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2020.024

DOXORUBICIN-INDUCED, TNF-α-MEDIATED BRAIN OXIDATIVE STRESS, NEUROCHEMICAL ALTERATIONS, AND COGNITIVE DECLINE: INSIGHTS INTO MECHANISMS OF CHEMOTHERAPY INDUCED COGNITIVE IMPAIRMENT AND ITS PREVENTION

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Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNFα

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