The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Protein oxidation and aging
Abstract
Organisms are constantly exposed to various forms of reactive oxygen species (ROS) that lead to oxidation of proteins, nucleic acids, and lipids. Protein oxidation can involve cleavage of the polypeptide chain, modification of amino acid side chains, and conversion of the protein to derivatives that are highly sensitive to proteolytic degradation. Unlike other types of modification (except cysteine oxidation), oxidation of methionine residues to methionine sulfoxide is reversible; thus, cyclic oxidation and reduction of methionine residues leads to consumption of ROS and thereby increases the resistance of proteins to oxidation. The importance of protein oxidation in aging is supported by the observation that levels of oxidized proteins increase with animal age. The age-related accumulation of oxidized proteins may reflect age-related increases in rates of ROS generation, decreases in antioxidant activities, or losses in the capacity to degrade oxidized proteins.
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Cites
Moskovitz, J., Rahman, M. A., Strassman, J., Yancey, S. O., Kushner, S. R., Brot, N., & Weissbach, H. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.3.502-507.1995 · Cited by 294
2‐Oxo‐histidine as a novel biological marker for oxidatively modified proteins
Uchida, K., & Kawakishi, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80632-5 · Cited by 146
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Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087
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Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
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Lee, B.-H., Lee, M. J., Park, S., Oh, D.-C., Elsasser, S., Chen, P.-C., Gartner, C., Dimova, N., Hanna, J., Gygi, S. P., et al. (2010) · Nature · doi:10.1038/nature09299 · Cited by 893
Molecular Mechanisms of Dermal Aging and Antiaging Approaches
Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875
Metadata
- Authors
- Stadtman, E. R.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 40
- Issue
- 12
- Pages
- 1250-1258
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W1999921360
- Cited by
- 1,056
- References
- 2
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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