The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies
Abstract
Damage to DNA by oxygen radicals and other reactive oxygen/nitrogen/chlorine species occurs in vivo despite the presence of multiple antioxidant defence and repair systems. Such damage is thought to make a significant contribution to the age-related development of cancer. Modulation of oxidative DNA damage by diet thus constitutes a "biomarker" putatively predictive of the effect of diet on cancer incidence, provided that DNA damage can be accurately quantitated by validated methods. Current issues addressed in this article include the problems of artifactual DNA oxidation during isolation and analysis, the relative merits of different analytical methods, the advantages and disadvantages of relying on measurement of 8-hydroxydeoxyguanosine (8OHdG, 8-oxodG) as an index of oxidative DNA damage, and the limited data that are so far available on how diet can affect "steady-state" levels of oxidative DNA damage in humans. It appears that such damage can be modulated by vegetable intake, although the effects of vegetables may be mediated by components different from the "classical" antioxidants vitamin C, alpha-tocopherol and beta-carotene.
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Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Alam, Z. I., Jenner, A., Daniel, S. E., Lees, A. J., Cairns, N., Marsden, C. D., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031196.x · Cited by 845
Self-citationVitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800
Lyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531
Self-citationRehman, A., Collis, C. S., Yang, M., Kelly, M., Diplock, A. T., Halliwell, B., & Rice-Evans, C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8592 · Cited by 202
Self-citation
Cited by
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Self-citationAntioxidant defence mechanisms: From the beginning to the end (of the beginning)
Halliwell, B. (1999) · Free Radical Research · doi:10.1080/10715769900300841 · Cited by 1,020
Self-citationBiomarkers of Oxidative Stress and Antioxidant Defense
Demirci-Çekiç, S., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114477 · Cited by 587
The gastrointestinal tract: A major site of antioxidant action?
Halliwell, B., Zhao, K., & Whiteman, M. (2000) · Free Radical Research · doi:10.1080/10715760000301341 · Cited by 513
Self-citationLeporatti, M. L., & Ivancheva, S. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00047-3 · Cited by 323
Metadata
- Authors
- Halliwell, B.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 29
- Issue
- 6
- Pages
- 469-486
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2129912243
- Cited by
- 170
- References
- 6
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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