Vitamin C exhibits pro-oxidant properties
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher doses of vitamin C can behave as a prooxidant.
“Higher doses of vitamin C can behave as a prooxidant [156,168,169]”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [168]
Cited by
Sorted by citations
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178 · see citing works
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949 · see citing works
Oxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · see citing works
Free radical-induced damage to DNA: mechanisms and measurement
Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953 · see citing works
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works
Vitamin C: The known and the unknown and Goldilocks
Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753 · see citing works
Halliwell, B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02075-4 · Cited by 655 · see citing works
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
Lin, J., Cook, N. R., Albert, C., Zaharris, E., Gaziano, J. M., Van Denburgh, M., Buring, J. E., & Manson, J. E. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn438 · Cited by 309 · see citing works
Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291 · see citing works
Mitochondria and cardiovascular diseases-from pathophysiology to treatment
Siasos, G., Tsigkou, V., Kosmopoulos, M., Theodosiadis, D., Simantiris, S., Tagkou, N. M., Tsimpiktsioglou, A., Stampouloglou, P. K., Oikonomou, E., Mourouzis, K., et al. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.06.21 · Cited by 245 · see citing works
Coronary Heart Disease in Smokers: Vitamin C Restores Coronary Microcirculatory Function
Kaufmann, P. A., Gnecchi-Ruscone, T., di Terlizzi, M., Schäfers, K. P., Lüscher, T. F., & Camici, P. G. (2000) · Circulation · doi:10.1161/01.cir.102.11.1233 · Cited by 246 · see citing works
Nutrition, Well-Being and Health
(2012) · doi:10.5772/1864 · Cited by 178 · see citing works
Seo, M.-Y., & Lee, S.-M. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00236-7 · Cited by 131 · see citing works
Common Presence of Non–Transferrin-Bound Iron Among Patients With Type 2 Diabetes
Lee, D.-H., Liu, D. Y., Jacobs, D. R., Shin, H.-R., Song, K., Lee, I.-K., Kim, B., & Hider, R. C. (2006) · Diabetes Care · doi:10.2337/dc05-2471 · Cited by 128 · see citing works
Kuhn, S.-O., Meissner, K., Mayes, L. M., & Bartels, K. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000549 · Cited by 82 · see citing works
Hininger, I., Waters, R., Osman, M., Garrel, C., Fernholz, K., Roussel, A. M., & Anderson, R. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.016 · Cited by 53 · see citing works
Cheignon, C., Collin, F., Faller, P., & Hureau, C. (2016) · Dalton Transactions · doi:10.1039/c6dt01979j · Cited by 39 · see citing works
- Authors
- Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J.
- Affiliations
- University of Leicester (GB)
- Venue
- Nature
- Published
- 1998-04-09
- Volume
- 392
- Issue
- 6676
- Pages
- 559-559
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1566419077
- Cited by
- 800
- References
- 0
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 17 · 2023: 22 · 2022: 22 · 2021: 19 · 2020: 26 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 24 · 2015: 19 · 2014: 25 · 2013: 32 · 2012: 31
- FWCI
- 48.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C, pro-oxidant activity, antioxidant activity, dietary supplements, oxidative stress, in vivo effects
- MeSH terms
- Adenine, Adult, Antioxidants, Ascorbic Acid, DNA, DNA Damage, Female, Humans, Lymphocytes, Male, Gas Chromatography-Mass Spectrometry, Middle Aged, Oxidants, Reactive Oxygen Species, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review