The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Regulatory mechanisms of cellular response to oxidative stress
Abstract
An antioxidant responsive element (ARE) or electrophile responsive element (EpRE) mediates the transcriptional activation of genes encoding phase II drug metabolizing enzymes. The ARE consensus sequence shows high similarity to an erythroid gene regulatory element, and based on the observation, we have recently found that transcription factor Nrf2 is essential for the coordinate induction of phase II detoxifying enzymes. The expression of anti-oxidative stress enzyme genes is also regulated by Nrf2. Detailed analysis of the regulatory mechanisms of Nrf2 activity has ultimately led us to the identification of a new protein, which we have named Keap1, that suppresses Nrf2 activity by specific binding to its evolutionarily-conserved N-terminal Neh2 regulatory domain.
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Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Self-citationMoi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607
Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464
Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., Yamamoto, M., & Igarashi, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6083 · Cited by 656
Self-citationChan, K., Lu, R., Chang, J. C., & Kan, Y. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13943 · Cited by 645
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
Andrews, N. C., Erdjument-Bromage, H., Davidson, M. B., Tempst, P., & Orkin, S. H. (1993) · Nature · doi:10.1038/362722a0 · Cited by 639
Friling, R. S., Bensimon, A., Tichauer, Y., & Daniel, V (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6258 · Cited by 475
Mulcahy, R. T., Wartman, M. A., Bailey, H. H., & Gipp, J. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7445 · Cited by 455
Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
Igarashi, K., Kataokat, K., Itoh, K., Hayashi, N., Nishizawa, M., & Yamamoto, M. (1994) · Nature · doi:10.1038/367568a0 · Cited by 443
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Cited by
Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,015
Molecular basis of the Keap1–Nrf2 system
Suzuki, T., & Yamamoto, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.006 · Cited by 995
Self-citationLee, J.-M., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 786
Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 785
Metadata
- Authors
- Itoh, K., Ishii, T., Wakabayashi, N., & Yamamoto, M.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 31
- Issue
- 4
- Pages
- 319-324
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2005568856
- Cited by
- 347
- References
- 32
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
