Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy
Open accessAbstract
Periplocymarin (PPM), a cardiac glycoside, has a narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity which hinder its wide clinical applications in cancer treatment. Herein, we report novel redox-responsive prodrug-nanoparticles (MPSSV-NPs) self-assembled by co-nanoprecipitation of PPM-vitamin E conjugate and a PEG derivative of linoleate (mPEG2000-LA) in water. It was found that the characteristics of PPM-vitamin E nanoparticles (PSSV-NPs) were improved through co-nanoprecipitation with increased percentages of mPEG2000-LA. Moreover, the MPSSV-NPs were optimized according to the in vitro release and cytotoxicity study. Furthermore, the optimized MPSSV-NPs dramatically enhanced the circulation time and tumor distribution of PSSV-NPs after single intravenous injection. The in vivo studies in malignant H22-bearing mice revealed that MPSSV-NPs could effectively suppress tumor growth without causing obvious systemic toxicity. Altogether, these results suggested that MPSSV-NPs could offer a safe, multifunctional and viable nanoplatform for cardiac glycosides in cancer treatment.
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MPSSV-NPs displayed prolonged circulation with an elimination half-life of 30.04 h, compared to PPM with 0.327 h.
“The pharmacokinetics of PSSV-NPs and MPSSV-NPs have displayed a prolonged circulation time with an elimination phase half-life (t1/2) of 3.339 and 30.04 h, respectively, compared to PPM with 0.327 h [40].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [40]
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- Authors
- Zhang, H., Xu, W., Omari-Siaw, E., Liu, Y., Chen, B., Chen, D., Yu, J., & Xu, X.
- Affiliations
- Jiangsu University (CN)
- Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People’s Republic of China;
- Affiliated Hospital of Jiangsu University (CN)
- Corresponding author
- Yu, Jiangnan
- Xu, Ximing
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2017-01-01
- Volume
- 24
- Issue
- 1
- Pages
- 1170-1178
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- PMC
- PMC8241199
- OpenAlex
- W2749402434
- Cited by
- 26
- References
- 45
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Drug Delivery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- cardiac glycosides, disulfide bonds, PEGylated nanoparticles, nanoparticle self-assembly, liver cancer chemotherapy, tumor targeting, circulation time, H22 hepatocellular carcinoma, drug delivery nanoplatform
- MeSH terms
- Animals, Cardiac Glycosides, Disulfides, Humans, Liver Neoplasms, Oxidation-Reduction, Prodrugs, Vitamin E, Mice, Nanoparticles
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