Sickle Red Cell–Endothelium Interactions
Open accessAbstract
Periodic recurrence of painful vaso‐occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell–endothelium interaction has been implicated as a potential initiating mechanism in vaso‐occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and microcirculatory findings on sickle red cell adhesion, its potential role in vaso‐occlusion, and the current understanding of receptor‐ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte–red cell interaction) to vaso‐occlusion, as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.
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Sickling-dependent erythrocyte membrane damage exposes adhesion molecules and binding motifs not normally present on erythrocytes, including phosphatidyl serine, B-CAM-1/Lu, IAP, and ICAM-4.
“Importantly, sickling-dependent damage of erythrocyte membranes also promotes exposure of adhesion molecules and binding motifs not normally expressed on erythrocytes, such as phosphatidyl serine (PS), basal cell adhesion molecule-1/Lutheran (B-CAM-1/Lu), integrin-associated protein (IAP), and intercellular-adhesion-molecule-4 (ICAM-4) (7, 9, 15).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [15]
The ADHESION MOLECULES section (page not supplied) identifies exposed PS and lists B-CAM-1/Lu, IAP, and ICAM-4 as molecules involved in sickle red-cell adhesion. It says the latter three require activation via signal transduction, not that sickling-dependent membrane damage exposes them. It also describes ICAM-4 as expressed on erythroid cells, so the claim that these molecules are not normally expressed on erythrocytes is not supported. (LLM, conf=0.89)
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Cites
Identification of the platelet ADP receptor targeted by antithrombotic drugs
Hollopeter, G., Jantzen, H., Vincent, D., Li, G., England, L. J., Ramakrishnan, V., Yang, R., Nurden, P., Nurden, A. T., Julius, D. J., et al. (2001) · Nature · doi:10.1038/35051599 · Cited by 1,421 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., et al. (2002) · Nature Medicine · doi:10.1038/nm799 · Cited by 1,097 · see citing works
Stuart, M. J., & Nagel, R. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17192-4 · Cited by 847 · see citing works
Circulating Activated Endothelial Cells in Sickle Cell Anemia
Solovey, A. N., Lin, Y., Browne, P., Choong, S., Wayner, E. A., & Hebbel, R. P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372203 · Cited by 626 · see citing works
Pfaff, M., Tangemann, K., Müller, B., Gurrath, M., Müller, G., Kessler, H., Timpl, R., & Engel, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31981-6 · Cited by 535 · see citing works
Erythrocyte Adherence to Endothelium in Sickle-Cell Anemia
Hebbel, R. P., Boogaerts, M., Eaton, J. W., & Steinberg, M. H. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005013021803 · Cited by 518 · see citing works
Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
Turhan, A., Weiss, L. A., Mohandas, N., Coller, B. S., & Frenette, P. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052522799 · Cited by 487 · see citing works
The Endothelial Biology of Sickle Cell Disease: Inflammation and a Chronic Vasculopathy
Hebbel, R. P., Osarogiagbon, R. U., & Kaul, D. K. (2004) · Microcirculation · doi:10.1080/10739680490278402 · Cited by 463 · see citing works
Self-citationSpontaneous oxygen radical generation by sickle erythrocytes.
Hebbel, R. P., Eaton, J. W., Balasingam, M., & Steinberg, M. H. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110724 · Cited by 441 · see citing works
Hemoglobin S gelation and sickle cell disease
Eaton, W., & Hofrichter, J. (1987) · Blood · doi:10.1182/blood.v70.5.1245.1245 · Cited by 425 · see citing works
Abnormal Adherence of Sickle Erythrocytes to Cultured Vascular Endothelium
Hebbel, R. P., Yamada, O., Moldow, C. F., Jacob, H. S., White, J. G., & Eaton, J. W. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109646 · Cited by 421 · see citing works
Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
Kaul, D. K., & Hebbel, R. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9225 · Cited by 413 · see citing works
Self-citationFetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea
Steinberg, M. H., Lu, Z.-H., Barton, F. B., Terrin, M. L., Charache, S., Dover, G. J., & Hydroxyurea, T. M. S. O. (1997) · Blood · doi:10.1182/blood.v89.3.1078 · Cited by 407 · see citing works
Villagra, J., Shiva, S., Hunter, L. A., Machado, R. F., Gladwin, M. T., & Kato, G. J. (2007) · Blood · doi:10.1182/blood-2006-12-061697 · Cited by 384 · see citing works
Čokić, V. P., Smith, R. D., Beleslin‐Čokić, B. B., Njoroge, J. M., Miller, J. L., Gladwin, M. T., & Schechter, A. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316672 · Cited by 377 · see citing works
Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology
Hebbel, R. (1991) · Blood · doi:10.1182/blood.v77.2.214.bloodjournal772214 · Cited by 362 · see citing works
Hemoglobin S gelation and sickle cell disease
Eaton, W., & Hofrichter, J. (1987) · Blood · doi:10.1182/blood.v70.5.1245.bloodjournal7051245 · Cited by 353 · see citing works
Kaul, D. K., Fabry, M. E., & Nagel, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3356 · Cited by 347 · see citing works
Self-citationHydroxyurea and Sickle Cell Anemia Clinical Utility of a Myelosuppressive “Switching” Agent
Charache, S., Barton, F. B., Moore, R. D., Terrin, M. L., Steinberg, M. H., Dover, G. J., Ballas, S. K., McMahon, R. P., Castro, O. L., & Orringer, E. P. (1996) · Medicine · doi:10.1097/00005792-199611000-00002 · Cited by 335 · see citing works
Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist
Storgard, C. M., Stupack, D. G., Jonczyk, A., Goodman, S. L., Fox, R. I., & Cheresh, D. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3756 · Cited by 310 · see citing works
Sickle cell anemia as an inflammatory disease
Platt, O. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10726 · Cited by 293 · see citing works
Swerlick, R., Eckman, J., Kumar, A. F., Jeitler, M., & Wick, T. (1993) · Blood · doi:10.1182/blood.v82.6.1891.1891 · Cited by 275 · see citing works
Regulation of Erythrocyte Cation and Water Content in Sickle Cell Anemia
Brugnara, C., Bunn, H. F., & Tosteson, D. C. (1986) · Science · doi:10.1126/science.3961486 · Cited by 268 · see citing works
Adhesive interactions of sickle erythrocytes with endothelium.
Hebbel, R. P. (1997) · PubMed · Cited by 263 · see citing works
P-selectin mediates the adhesion of sickle erythrocytes to the endothelium
Matsui, N. M., Borsig, L., Rosen, S. D., Yaghmai, M., Varki, A. P., & Embury, S. H. (2001) · Blood · doi:10.1182/blood.v98.6.1955 · Cited by 241 · see citing works
Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures
Hoover, R. L., Rubin, R. W., Wise, G., & Warren, R. (1979) · Blood · doi:10.1182/blood.v54.4.872.872 · Cited by 233 · see citing works
Kaul, D. K., Fabry, M. E., Windisch, P., Baez, S., & Nagel, R. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110960 · Cited by 226 · see citing works
Self-citationRole of erythrocyte phosphatidylserine in sickle red cell–endothelial adhesion
Setty, Y. B. N., Kulkarni, S., & Stuart, M. J. (2002) · Blood · doi:10.1182/blood.v99.5.1564 · Cited by 211 · see citing works
Brittain, H. A., Eckman, J., Swerlick, R., Rj, H., & Wick, T. M. (1993) · Blood · doi:10.1182/blood.v81.8.2137.2137 · Cited by 206 · see citing works
Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells
Sugihara, K., Sugihara, T., Mohandas, N., & Hebbel, R. (1992) · Blood · doi:10.1182/blood.v80.10.2634.bloodjournal80102634 · Cited by 206 · see citing works
Supersaturation in sickle cell hemoglobin solutions.
Hofrichter, J., Ross, P. D., & Eaton, W. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3035 · Cited by 202 · see citing works
Cation transport and volume regulation in sickle red blood cells
Joiner, C. H. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c251 · Cited by 189 · see citing works
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy
Bridges, K., Barabino, G., Brugnara, C., Cho, M., Christoph, G., Dover, G., Ewenstein, B., Golan, D., Guttmann, C., Hofrichter, J., et al. (1996) · Blood · doi:10.1182/blood.v88.12.4701.bloodjournal88124701 · Cited by 184 · see citing works
Self-citationKaul, D. K., Tsai, H., Liu, X. D., Nakada, M. T., Nagel, R. L., & Coller, B. S. (2000) · Blood · doi:10.1182/blood.v95.2.368 · Cited by 181 · see citing works
Self-citationNovel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion
Hines, P. C., Zen, Q., Burney, S. N., Shea, D. A., Ataga, K. I., Orringer, E. P., Telen, M. J., & Parise, L. V. (2003) · Blood · doi:10.1182/blood-2001-12-0289 · Cited by 180 · see citing works
Barabino, G., McIntire, L., Eskin, S. G., Sears, D. A., & Udden, M. M. (1987) · Blood · doi:10.1182/blood.v70.1.152.bloodjournal701152 · Cited by 165 · see citing works
Self-citationRheologic predictors of the severity of the painful sickle cell crisis
Ballas, S., Larner, J. M., Smith, E. R., Surrey, S., Schwartz, E., & Rappaport, E. F. (1988) · Blood · doi:10.1182/blood.v72.4.1216.1216 · Cited by 158 · see citing works
Wick, T. M., Moake, J. L., Udden, M. M., Eskin, S. G., Sears, D. A., & McIntire, L. V. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113151 · Cited by 157 · see citing works
Zennadi, R., Hines, P. C., Castro, L. M. D., Cartron, J., Parise, L. V., & Telen, M. J. (2004) · Blood · doi:10.1182/blood-2004-01-0042 · Cited by 153 · see citing works
Hebbel, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119442 · Cited by 147 · see citing works
Mohandas, N., & Evans, E. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112144 · Cited by 145 · see citing works
Embury, S. H. (2004) · Blood · doi:10.1182/blood-2004-02-0713 · Cited by 141 · see citing works
Kaul, D. K., Fabry, M. E., Costantini, F. D., Rubin, E. M., & Nagel, R. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118355 · Cited by 132 · see citing works
Self-citationSultana, C., Shen, Y. M., Rattan, V., Johnson, C. S., & Kalra, V. K. (1998) · Blood · doi:10.1182/blood.v92.10.3924 · Cited by 130 · see citing works
Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin
Matsui, N. M., Varki, A., & Embury, S. H. (2002) · Blood · doi:10.1182/blood-2002-02-0626 · Cited by 123 · see citing works
Brittain, J. E., Mlinar, K. J., Anderson, C., Orringer, E. P., & Parise, L. V. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10817 · Cited by 119 · see citing works
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo
Zennadi, R., Moeller, B. J., Whalen, E. J., Batchvarova, M., Xu, K., Shan, S., Delahunty, M. D., Dewhirst, M. W., & Telen, M. J. (2007) · Blood · doi:10.1182/blood-2006-11-056101 · Cited by 118 · see citing works
Fabry, M. E., & Nagel, R. L. (1982) · PubMed · Cited by 111 · see citing works
Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice
Kaul, D. K., Liu, X.-D., Chang, H.-Y., Nagel, R. L., & Fabry, M. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21633 · Cited by 108 · see citing works
Self-citationHydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells
Čokić, V. P., Andrić, S. A., Stojilković, S. S., Noguchi, C. T., & Schechter, A. N. (2007) · Blood · doi:10.1182/blood-2007-05-088732 · Cited by 104 · see citing works
Chang, J., Shi, P. A., Chiang, E. Y., & Frenette, P. S. (2007) · Blood · doi:10.1182/blood-2007-04-084061 · Cited by 101 · see citing works
Hebbel, R., Moldow, C., & Steinberg, M. (1981) · Blood · doi:10.1182/blood.v58.5.947.947 · Cited by 100 · see citing works
Turhan, A., Jenab, P., Bruhns, P., Ravetch, J. V., Coller, B. S., & Frenette, P. S. (2003) · Blood · doi:10.1182/blood-2003-07-2209 · Cited by 93 · see citing works
Increased circulating endothelial cells in sickle cell crisis
Sowemimo-Coker, S. O., Meiselman, H. J., & Francis, R. B. (1989) · American Journal of Hematology · doi:10.1002/ajh.2830310409 · Cited by 90 · see citing works
In vivo visualization of oxidative changes in microvessels during neutrophil activation
Suematsu, M., Schmid‐Schönbein, G. W., Chavez-Chavez, R. H., Yee, T. T., Tamatani, T., Miyasaka, M., DeLano, F. A., & Zweifach, B. W. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.3.h881 · Cited by 90 · see citing works
Blockade of Adhesion of Sickle Cells to Endothelium by Monoclonal Antibodies
Hebbel, R. P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422512 · Cited by 82 · see citing works
In Vivo Studies of Sickle Red Blood Cells
Kaul, D. K., & Fabry, M. E. (2004) · Microcirculation · doi:10.1080/10739680490278457 · Cited by 82 · see citing works
Self-citationThe percentage of dense red cells does not predict incidence of sickle cell painful crisis
Billett, H., Kim, K., Fabry, M. E., & Nagel, R. L. (1986) · Blood · doi:10.1182/blood.v68.1.301.301 · Cited by 78 · see citing works
Wood, K. C., Hebbel, R. P., & Granger, D. N. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01056.2003 · Cited by 68 · see citing works
Barabino, G. A., Liu, X. D., Ewenstein, B. M., & Kaul, D. K. (1999) · Blood · doi:10.1182/blood.v93.4.1422 · Cited by 63 · see citing works
Self-citationMankelow, T. J., Spring, F. A., Parsons, S. F., Brady, R. L., Mohandas, N., Chasis, J. A., & Anstee, D. J. (2003) · Blood · doi:10.1182/blood-2003-08-2792 · Cited by 60 · see citing works
Second generation knockout sickle mice: the effect of HbF
Fabry, M. E., Suzuka, S. M., Weinberg, R. S., Lawrence, C., Factor, S. M., Gilman, J. G., Costantini, F. D., & Nagel, R. L. (2001) · Blood · doi:10.1182/blood.v97.2.410 · Cited by 59 · see citing works
Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants
Kaul, D. K., Liu, X.-D., Zhang, X., Ma, L., Hsia, C. J. C., & Nagel, R. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01096.2005 · Cited by 57 · see citing works
Self-citationAn Unusual Pattern of Neutrophil Kinetics in Sickle Cell Anemia
Boggs, D. R., Hyde, F. W., & Srodes, C. H. (1973) · Blood · doi:10.1182/blood.v41.1.59.59 · Cited by 55 · see citing works
Kaul, D. K., Fabry, M. E., & Nagel, R. L. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb24179.x · Cited by 53 · see citing works
Self-citationKaul, D. K., Liu, X.-D., Zhang, X., Mankelow, T. J., Parsons, S. F., Spring, F., An, X., Mohandas, N., Anstee, D. J., & Chasis, J. A. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00639.2005 · Cited by 53 · see citing works
Self-citationErythrocyte-endothelial cell adherence in sickle cell disorders
Smith, B., & Celle, P. L. (1986) · Blood · doi:10.1182/blood.v68.5.1050.1050 · Cited by 49 · see citing works
Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso‐occlusion
Finnegan, E. M., Turhan, A., Golan, D. E., & Barabino, G. A. (2006) · American Journal of Hematology · doi:10.1002/ajh.20819 · Cited by 47 · see citing works
Self-citationA 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
Cao, Z., & Ferrone, F. A. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0079 · Cited by 45 · see citing works
Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesion
Setty, Y. B. N., Kulkarni, S., Dampier, C., & Stuart, M. J. (2001) · Blood · doi:10.1182/blood.v97.9.2568 · Cited by 41 · see citing works
Manodori, A. B., Matsui, N. M., Chen, J. Y., & Embury, S. H. (1998) · Blood · doi:10.1182/blood.v92.9.3445 · Cited by 36 · see citing works
Rheologic and hemodynamic characteristics of red cells of mouse, rat and human
Chen, D., & Kaul, D. K. (1994) · Biorheology · doi:10.3233/bir-1994-31109 · Cited by 36 · see citing works
Self-citationCytokines and Soluble Adhesion Molecules in Sickle Cell Anemia Patients during Hydroxyurea Therapy
Saleh, A. W., Duits, A. J., Gerbers, A., de Vries, C., & Hillen, H. F. P. (1998) · Acta Haematologica · doi:10.1159/000040859 · Cited by 35 · see citing works
Finnegan, E. M., Barabino, G. A., Liu, X.-D., Chang, H.-Y., Jonczyk, A., & Kaul, D. K. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01054.2006 · Cited by 35 · see citing works
Self-citationRheological studies of erythrocyte-endothelial cell interactions in sickle cell disease.
Barabino, G. A., McIntire, L. V., Eskin, S. G., Sears, D. A., & Udden, M. M. (1987) · PubMed · Cited by 32 · see citing works
Self-citationIyamu, W. E., Adunyah, S. E., Fasold, H., Horiuchi, K., Elford, H. L., Asakura, T., & Turner, E. (2000) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(200004)63:4 · Cited by 27 · see citing works
Hebbel, R. P., Eaton, J. W., Steinberg, M. H., & Jg, W. (1982) · PubMed · Cited by 26 · see citing works
Oxidative Stress During Platelet‐Activating Factor‐Induced Microvascular Dysfunction
Kurose, I., Argenbright, L. W., Wolf, R., & Granger, D. N. (1996) · Microcirculation · doi:10.3109/10739689609148313 · Cited by 23 · see citing works
Kaul, D. K., Kollander, R., Mahaseth, H., Liu, X. D., Solovey, A. N., Belcher, J. D., Kelm, R. J., Vercellotti, G. M., & Hebbel, R. P. (2006) · Microcirculation · doi:10.1080/10739680600778456 · Cited by 19 · see citing works
Self-citationSickle erythrocytes adhere to endothelial cell monolayers (ECM's) exposed to flowing blood.
Ef, G. (1987) · PubMed · Cited by 18 · see citing works
Alterations by leukocytes of erythrocyte flow in microchannels.
Celle, P. L. L. (1986) · PubMed · Cited by 15 · see citing works
Erythrocyte/endothelial interactions and the vasocclusive severity of sickle cell disease.
Hebbel, R., Eaton, J. W., Steinberg, M. H., & Jg, W. (1981) · PubMed · Cited by 14 · see citing works
Kinetic Models and the Pathophysiology of Sickle Cell Diseasea
Ferrone, F. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb24151.x · Cited by 14 · see citing works
Circulating endothelial cells in sickle cell anemia.
Ortiz, A. J. (1998) · PubMed · Cited by 10 · see citing works
Circulating Endothelial Cells in Sickle Cell Anemia
Hughes-Davies, T. H. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804163381617 · Cited by 6 · see citing works
Flagged first, then by citations
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- [52]Kaul DK Tsai HM Nagel RL Chen D Beuzard Y Platelet-activating factor enhances adhesion of sickle erythrocytes to vascular endothelium: the role of vascular integrin αvβ3 and von Willebrand factor Sickle cell disease and thalassemias:New trends in therapy (INSERM Symposium) 1995 497 500 INSERM/John Libbey Eurotext Montrouge, France
Cited by
Sorted by citations
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Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813 · see citing works
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Manwani, D., & Frenette, P. S. (2013) · Blood · doi:10.1182/blood-2013-05-498311 · Cited by 428 · see citing works
Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood · doi:10.1182/blood-2015-09-618538 · Cited by 413 · see citing works
Barabino, G. A., Platt, M. O., & Kaul, D. K. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105339 · Cited by 311 · see citing works
Self-citationTsai, M., Kita, A., Leach, J., Rounsevell, R., Huang, J. N., Moake, J., Ware, R. E., Fletcher, D. A., & Lam, W. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58753 · Cited by 297 · see citing works
Role of red blood cells in haemostasis and thrombosis
Игоревич, Л. Р., & Weisel, J. W. (2016) · ISBT Science Series · doi:10.1111/voxs.12331 · Cited by 217 · see citing works
Shear-induced particle migration and margination in a cellular suspension
Zhao, H., Shaqfeh, E. S. G., & Narsimhan, V. (2012) · Physics of Fluids · doi:10.1063/1.3677935 · Cited by 189 · see citing works
Biomarkers in sickle cell disease
Rees, D. C., & Gibson, J. S. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08961.x · Cited by 153 · see citing works
Sickle Cell Disease: Advances in Treatment
Gardner, R. V. (2018) · Ochsner Journal · doi:10.31486/toj.18.0076 · Cited by 134 · see citing works
Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis
Du, E., Diez-Silva, M., Kato, G. J., Dao, M., & Suresh, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424111112 · Cited by 120 · see citing works
Daak, A. A., Ghebremeskel, K., Hassan, Z., Attallah, B., Azan, H. H., Elbashir, M. I., & Crawford, M. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.036319 · Cited by 120 · see citing works
Biomechanics and biorheology of red blood cells in sickle cell anemia
Li, X., Dao, M., Lykotrafitis, G., & Karniadakis, G. E. (2016) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2016.11.022 · Cited by 119 · see citing works
Microvascular thrombosis: experimental and clinical implications
Bray, M. A., Sartain, S. E., Gollamudi, J., & Rumbaut, R. E. (2020) · Translational research · doi:10.1016/j.trsl.2020.05.006 · Cited by 119 · see citing works
Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease
Alapan, Y., Little, J. A., & Gurkan, U. A. (2014) · Scientific Reports · doi:10.1038/srep07173 · Cited by 113 · see citing works
Chadebech, P., Habibi, A., Nzouakou, R., Bachir, D., Meunier‐Costes, N., Bonin, P., Rodet, M., Chami, B., Galactéros, F., Bierling, P., et al. (2009) · Transfusion · doi:10.1111/j.1537-2995.2009.02199.x · Cited by 113 · see citing works
Advances in the Treatment of Sickle Cell Disease
Kapoor, S., Little, J. A., & Pecker, L. H. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.08.001 · Cited by 104 · see citing works
Advances in understanding the pathogenesis of cerebrovascular vasculopathy in sickle cell anaemia
Connes, P., Verlhac, S., & Bernaudin, F. (2013) · British Journal of Haematology · doi:10.1111/bjh.12300 · Cited by 102 · see citing works
Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies
Manwani, D. G., & Frenette, P. S. (2013) · Hematology · doi:10.1182/asheducation-2013.1.362 · Cited by 91 · see citing works
Tebbi, C. K. (2022) · Hemato · doi:10.3390/hemato3020024 · Cited by 89 · see citing works
Alapan, Y., Kim, C., Adhikari, A., Gray, K. E., Gürkan-Çavusoglu, E., Little, J. A., & Gurkan, U. A. (2016) · Translational research · doi:10.1016/j.trsl.2016.03.008 · Cited by 76 · see citing works
Leonard, A. K., Bonifacino, A. C., Dominical, V. M., Luo, M., Haro‐Mora, J. J., Demirci, S., Uchida, N., Pierciey, F. J., & Tisdale, J. F. (2019) · British Journal of Haematology · doi:10.1111/bjh.15902 · Cited by 76 · see citing works
Dynamic deformability of sickle red blood cells in microphysiological flow
Alapan, Y., Matsuyama, Y., Little, J. A., & Gurkan, U. A. (2016) · TECHNOLOGY · doi:10.1142/s2339547816400045 · Cited by 76 · see citing works
Hemoglobin disorders and endothelial cell interactions
Conran, N., & Costa, F. F. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.024 · Cited by 75 · see citing works
Simultaneous polymerization and adhesion under hypoxia in sickle cell disease
Papageorgiou, D. P., Abidi, S. Z., Chang, H.-Y., Li, X., Kato, G. J., Karniadakis, G. E., Suresh, S., & Dao, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807405115 · Cited by 75 · see citing works
Ischemia-Reperfusion Injury in Sickle Cell Disease
Ansari, J., & Gavins, F. N. E. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.12.012 · Cited by 78 · see citing works
Clinical biomarkers in sickle cell disease
Damanhouri, G. A., Jarullah, J. S., Marouf, S., Hindawi, S., Mushtaq, G., & Kamal, M. A. (2014) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2014.09.005 · Cited by 72 · see citing works
AAAPT Diagnostic Criteria for Acute Sickle Cell Disease Pain
Field, J. J., Ballas, S. K., Campbell, C. M., Crosby, L. E., Dampier, C., Darbari, D. S., McClish, D. K., Smith, W. R., & Zempsky, W. T. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.12.003 · Cited by 71 · see citing works
Kucukal, E., Man, Y., Hill, A., Liu, S., Bode, A., An, R., Kadambi, J. R., Little, J. A., & Gurkan, U. A. (2020) · American Journal of Hematology · doi:10.1002/ajh.25933 · Cited by 71 · see citing works
Role of Endothelial Cells in Acute and Chronic Thrombosis
Bochenek, M. L., & Schäfer, K. (2019) · Hämostaseologie · doi:10.1055/s-0038-1675614 · Cited by 71 · see citing works
Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
Wun, T., Styles, L., DeCastro, L., Telen, M. J., Kuypers, F., Cheung, A., Kramer, W., Flanner, H., Rhee, S., Magnani, J. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101301 · Cited by 69 · see citing works
Henry, E. R., Cellmer, T., Dunkelberger, E. B., Metaferia, B., Hofrichter, J., Li, Q., Ostrowski, D., Ghirlando, R., Louis, J. M., Moutereau, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922004117 · Cited by 65 · see citing works
Emerging point-of-care technologies for sickle cell disease screening and monitoring
Alapan, Y., Fraiwan, A., Kucukal, E., Hasan, M. N., Ung, R., Kim, M., Odame, I., Little, J. A., & Gurkan, U. A. (2016) · Expert Review of Medical Devices · doi:10.1080/17434440.2016.1254038 · Cited by 63 · see citing works
Review/overview of pain in sickle cell disease
Ballas, S. K., & Darbari, D. S. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102327 · Cited by 60 · see citing works
The delay time in sickle cell disease after 40 years: A paradigm assessed
Ferrone, F. A. (2015) · American Journal of Hematology · doi:10.1002/ajh.23958 · Cited by 56 · see citing works
PERIOPERATIVE MANAGEMENT OF SICKLE CELL DISEASE: A NARRATIVE REVIEW
Adjepong, K., Otegbeye, F., & Adjepong, Y. (2018) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2018.032 · Cited by 56 · see citing works
Daak, A. A., Elderdery, A. Y., Elbashir, L. M., Mariniello, K., Mills, J. J., Scarlett, G. P., Elbashir, M. I., & Ghebremeskel, K. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.03.014 · Cited by 54 · see citing works
Hatzipantelis, E., Pana, Z. D., Gombakis, N., Ταπάρκου, Ά., Tzimouli, V., Kleta, D., Zafeiriou, D., Garipidou, V., Kanakoudi, F. G., & Athanassiou, M. (2013) · International Journal of Hematology · doi:10.1007/s12185-013-1392-y · Cited by 54 · see citing works
Does physical activity increase or decrease the risk of sickle cell disease complications?
Martin, C., Pialoux, V., Faës, C., Charrin, E., Skinner, S. C., & Connes, P. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095317 · Cited by 55 · see citing works
Kucukal, E., Ilich, A., Key, N. S., Little, J. A., & Gurkan, U. A. (2018) · American Journal of Hematology · doi:10.1002/ajh.25159 · Cited by 52 · see citing works
THE EVOLVING PHARMACOTHERAPEUTIC LANDSCAPE FOR THE TREATMENT OF SICKLE CELL DISEASE
Ballas, S. K. (2020) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2020.010 · Cited by 52 · see citing works
Koehl, B., Nivoit, P., Nemer, W. E., Lenoir, O., Hermand, P., Pereira, C., Brousse, V. A. M., Guyonnet, L., Ghinatti, G., Benkerrou, M., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.156869 · Cited by 47 · see citing works
Man, Y., Goreke, U., Kucukal, E., Hill, A., An, R., Liu, S., Bode, A., Solis-Fuentes, A., Nayak, L. V., Little, J. A., et al. (2020) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2020.102424 · Cited by 46 · see citing works
The relation of C-reactive protein to vasoocclusive crisis in children with sickle cell disease
Mohammed, F. A.-K., Mahdi, N., Sater, M. S., Al‐Ola, K., & Almawi, W. Y. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.08.003 · Cited by 45 · see citing works
Red cell adhesion in human diseases
Colin, Y., Kim, C. L. V., & Nemer, W. E. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000036 · Cited by 41 · see citing works
Cellular-level near-wall unsteadiness of high-hematocrit erythrocyte flow using confocal μPIV
Patrick, M. J., Chen, C., Frakes, D. H., Dur, O., & Pekkan, K. (2010) · Experiments in Fluids · doi:10.1007/s00348-010-0943-8 · Cited by 40 · see citing works
Foell, J. L., Pfirstinger, B., Rehe, K., Wolff, D., Holler, E., & Corbacioglu, S. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.49 · Cited by 38 · see citing works
Bennewitz, M. F., Watkins, S. C., & Sundd, P. (2014) · IntraVital · doi:10.4161/intv.29748 · Cited by 37 · see citing works
Daak, A. A., Dampier, C., Fuh, B., Kanter, J., Alvarez, O. A., Black, L. V., McNaull, M. A., Callaghan, M. U., George, A., Neumayr, L., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021444 · Cited by 37 · see citing works
Aich, A., Jones, M. K., & Gupta, K. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000491 · Cited by 37 · see citing works
Eleutério, R. M. N., Nascimento, F. O., de Araújo, T. G., de Castro, M. F., Filho, T. P. D. A., Filho, P. A. M., Eleutério, J., Elias, D. B. D., & Lemes, R. P. G. (2019) · Advances in Hematology · doi:10.1155/2019/4397150 · Cited by 36 · see citing works
Hermand, P., Azouzi, S., Gautier, E., Guillonneau, F., Bondet, V., Duffy, D., Dechavanne, S., Tharaux, P., Mayeux, P., Kim, C. L. V., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.238295 · Cited by 34 · see citing works
Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells
Deng, Y., Papageorgiou, D. P., Chang, H.-Y., Abidi, S. Z., Li, X., Dao, M., & Karniadakis, G. E. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.12.008 · Cited by 33 · see citing works
Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications
Obeagu, E. I., Ubosi, N. I., Obeagu, G. U., Egba, S. I., & Bluth, M. H. (2024) · Medicine · doi:10.1097/md.0000000000036898 · Cited by 27 · see citing works
Microarchitectural and mechanical characterization of the sickle bone
Green, M., Akinsami, I., Lin, A., Banton, S., Ghosh, S., Chen, B., Platt, M. O., Osunkwo, I., Ofori-Acquah, S. F., Guldberg, R. E., et al. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.04.019 · Cited by 27 · see citing works
Self-citationHypoxia/reoxygenation stress increases markers of vaso-occlusive crisis in sickle SAD mice
Aufradet, É., DeSouza, G., Bourgeaux, V., Bessaad, A., Campion, Y., Canet‐Soulas, E., Pialoux, V., Chirico, E. N., Chevrier, A., Godfrin, Y., et al. (2013) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-131735 · Cited by 27 · see citing works
Sickle cell disease: Hemostatic and inflammatory changes, and their interrelation
Toledo, S. L. D. O., Guedes, J. V. M., Alpoim, P. N., Rios, D. R. A., & Pinheiro, M. D. B. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.026 · Cited by 26 · see citing works
Research in Sickle Cell Disease: From Bedside to Bench to Bedside
Cisneros, G. S., & Thein, S. L. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000584 · Cited by 25 · see citing works
State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease
Puri, L., Nottage, K. A., Hankins, J. S., & Anghelescu, D. L. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0263-z · Cited by 28 · see citing works
Emerging drugs for sickle cell anemia
Singh, P. C., & Ballas, S. K. (2014) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2015.985587 · Cited by 24 · see citing works
Airway inflammation in sickle cell disease—A translational perspective
De, A., Manwani, D. G., & Rastogi, D. (2018) · Pediatric Pulmonology · doi:10.1002/ppul.23932 · Cited by 24 · see citing works
Terman, D. S., Viglianti, B. L., Zennadi, R., Fels, D. R., Boruta, R. J., Yuan, H., Dreher, M. R., Grant, G. A., Rabbani, Z. N., Moon, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052543 · Cited by 23 · see citing works
Trauma-Hemorrhagic Shock Induces a CD36-Dependent RBC Endothelial-Adhesive Phenotype
Deitch, E. A., Condon, M. R., Feketeova, E., Machiedo, G. W., Mason, L., Vinluan, G. M., Alli, V. V., Neal, M. D., Tomaio, J. N., Fishman, J. E., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0000000000000119 · Cited by 23 · see citing works
Lu, X., Galarneau, M., Higgins, J. M., & Wood, D. K. (2017) · Microcirculation · doi:10.1111/micc.12357 · Cited by 23 · see citing works
Meier, E. R., Fasano, R. M., Estrada, M., He, J., Luban, N. L. C., & McCarter, R. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.10.031 · Cited by 22 · see citing works
Oxidative stress activates red cell adhesion to laminin in sickle cell disease
Lizarralde-Iragorri, M. A., Lefevre, S. D., Cochet, S., Hoss, S. E., Brousse, V. A. M., Filipe, A., Dussiot, M., Azouzi, S., Kim, C. L. V., Rodrigues‐Lima, F., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.261586 · Cited by 22 · see citing works
Neutrophils as drivers of vascular injury in sickle cell disease
Torres, L. S., & Hidalgo, A. (2022) · Immunological Reviews · doi:10.1111/imr.13146 · Cited by 22 · see citing works
Efficacy of homologous inositol hexaphosphate‐loaded red blood cells in sickle transgenic mice
Bourgeaux, V., Aufradet, É., Campion, Y., Souza, G. D., Horand, F., Bessaad, A., Chevrier, A., Canet‐Soulas, E., Godfrin, Y., & Martin, C. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09077.x · Cited by 20 · see citing works
Alkindi, S. S. A., Al-Ghadani, A. R., Al-Zeheimi, S. R., Alkindi, S. Y., Fawaz, N., Ballas, S. K., & Pathare, A. V. (2021) · Journal of International Medical Research · doi:10.1177/03000605211055385 · Cited by 18 · see citing works
Neutrophil microdomains: linking heterocellular interactions with vascular injury
Scheiermann, C., Kunisaki, Y., Jang, J.-E., & Frenette, P. S. (2009) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328333d2a3 · Cited by 18 · see citing works
Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -
Torres, L. S., Asada, N., Weiss, M. J., Trumpp, A., Suda, T., Scadden, D. T., & Ito, K. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.06.004 · Cited by 16 · see citing works
Abdul-Hussein, H. K., Al-Mamoori, H. S., & Hassan, M. K. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155534 · Cited by 15 · see citing works
MTHFR Polymorphic Variant C677T Is Associated to Vascular Complications in Sickle-Cell Disease
Hatzlhofer, B. L. D., Bezerra, M. A. C., Santos, M. N. N., de Albuquerque, D. M., Freitas, E. M., Costa, F. F., Araujo, A. S., & Muniz, M. T. C. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2011.0361 · Cited by 15 · see citing works
Riley, T. R., & Riley, T. T. (2019) · Journal of Blood Medicine · doi:10.2147/jbm.s191423 · Cited by 15 · see citing works
Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease
Venugopal, J., Wang, J., Mawri, J., Guo, C., & Eitzman, D. T. (2020) · Haematologica · doi:10.3324/haematol.2020.252395 · Cited by 15 · see citing works
Mean platelet volume can predict cerebrovascular events in patients with Sickle Cell Anemia
Çelik, T., Ünal, Ş., Ekıncı, O., Özer, C., İlhan, G., Oktay, G., & Arıca, V. (2014) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.311.4104 · Cited by 14 · see citing works
Erukainure, O. L., Ajiboye, J., Abbah, U., Asieba, G. O., Mamuru, S. A., Zaruwa, M. Z., Manhas, N., Singh, P., & Islam, M. (2017) · Human & Experimental Toxicology · doi:10.1177/0960327117712385 · Cited by 14 · see citing works
Sickle Cell Disease Pathophysiology and Related Molecular and Biophysical Biomarkers
Saah, E. N., Fadaei, P., Gurkan, U. A., & Sheehan, V. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.06.005 · Cited by 13 · see citing works
Opene, M., Kurantsin‐Mills, J., Husain, S., & Ibe, B. O. (2014) · Pulmonary Circulation · doi:10.1086/677363 · Cited by 13 · see citing works
Najjar, S. A., Adam, S. S., Ahmed, N., & Qari, M. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2823-7 · Cited by 13 · see citing works
Clinical Implications of Single-Cell Microfluidic Devices for Hematological Disorders
Hansen, C. E., & Lam, W. A. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b01013 · Cited by 13 · see citing works
Silva, M., & Faustino, P. (2023) · Antioxidants · doi:10.3390/antiox12111977 · Cited by 16 · see citing works
Plasma Ischemia Modified Albumin Levels and Dynamic Thiol / Disulfide Balance in Sickle Cell Disease
Özcan, O., Erdal, H., İlhan, G., Demir, D., Gürpınar, A. B., Neşeli̇oğlu, S., & Erel, Ö. (2018) · Turkish Journal of Hematology · doi:10.4274/tjh.2018.0119 · Cited by 12 · see citing works
Al‐Subaie, A. M., Fawaz, N., Mahdi, N., Al‐Absi, I. K., Al‐Ola, K., Ameen, G., & Almawi, W. Y. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01339.x · Cited by 12 · see citing works
Sahu, T. A., Pande, B., Verma, H. K., Bhaskar, L. V., Sinha, M., Sinha, R., & Rao, P. V. (2023) · Thalassemia Reports · doi:10.3390/thalassrep13030019 · Cited by 11 · see citing works
Pathobiology of Sickle Cell Disease
Hebbel, R. P., & Vercellotti, G. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00041-x · Cited by 11 · see citing works
Thrombo-Inflammation in COVID-19 and Sickle Cell Disease: Two Faces of the Same Coin
Chiang, K. C., Gupta, A., Sundd, P., & Krishnamurti, L. (2023) · Biomedicines · doi:10.3390/biomedicines11020338 · Cited by 10 · see citing works
Ranque, B., Diaw, M., Dembélé, A. K., Lapouméroulie, C., Offredo, L., Tessougué, O., Gueye, S. M., Diallo, D. A., Diop, S., Colin, Y., et al. (2023) · British Journal of Haematology · doi:10.1111/bjh.19006 · Cited by 11 · see citing works
Sawadogo, D., Tolo-Dilkébié, A., Mahawa, S., Aguéhoundé, N., Kassi, H., & Latte, T. (2014) · Advances in Hematology · doi:10.1155/2014/273860 · Cited by 11 · see citing works
Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease.
Stirnemann, J., Letellier, E., Aras, N., Borne, M., Brinquin, L., & Fain, O. (2012) · PubMed · Cited by 10 · see citing works
Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease
Rached, N. A., Gbotosho, O. T., Archer, D. R., Jones, J. A., Sterling, M. S., & Hyacinth, H. I. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.976063 · Cited by 10 · see citing works
Role of blood viscosity in the microcirculation
Jung, F., & RAMPLING, M. W. (2016) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-168108 · Cited by 10 · see citing works
Identification of Aptamers That Bind to Sickle Hemoglobin and Inhibit Its Polymerization
Purvis, S. H., Keefer, J. R., Fortenberry, Y. M., Barron‐Casella, E. A., & Casella, J. F. (2017) · Nucleic Acid Therapeutics · doi:10.1089/nat.2016.0646 · Cited by 10 · see citing works
Chamouine, A., Saandi, T., Muszlak, M., Larmaraud, J., Lambrecht, L., Poisson, J. P., Balicchi, J., Pissard, S., & Elenga, N. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-02187-6 · Cited by 10 · see citing works
Niesor, E. J., Benghozi, R., Amouyel, P., Ferdinand, K. C., & Schwartz, G. G. (2015) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-015-6626-1 · Cited by 10 · see citing works
Targeting PIEZO1 ‐ TMEM16F Coupling to Mitigate Sickle Cell Disease Complications
Liang, P., Wan, Y., Shan, K. Z., Chou, R., Zhang, Y., Delahunty, M. D., Khandelwal, S., Francis, S., Arepally, G. M., Telen, M. J., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.70086 · Cited by 9 · see citing works
Lu, M., Kanne, C. K., Reddington, R. C., Lezzar, D. L., Sheehan, V., & Shevkoplyas, S. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.633080 · Cited by 9 · see citing works
Pain Control for Sickle Cell Crisis, a Novel Approach? A Retrospective Study
Rollé, A., Vidal, E., Laguette, P., Garnier, Y., Delta, D., Martino, F., Portecop, P., Etienne‐Julan, M., Piednoir, P., JONG, A. D., et al. (2023) · Medicina · doi:10.3390/medicina59122196 · Cited by 9 · see citing works
Enfermedades hematológicas: desde dentro del corazón
Xu, W., Wang, T. Y., & Becker, R. C. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.02.018 · Cited by 9 · see citing works
Inflammation and Sickle Cell Anemia
Almeida, C. B., Kato, G. J., & Conran, N. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_8 · Cited by 9 · see citing works
Nugent, W. H., Jubin, R., Buontempo, P. J., Kazo, F., & Song, B. K. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1543197 · Cited by 9 · see citing works
- Authors
- KAUL, D. K., FINNEGAN, E., & BARABINO, G. A.
- Affiliations
- Albert Einstein College of Medicine (US)
- Georgia Institute of Technology (US)
- Corresponding author
- KAUL, DHANANJAY K.
- ORCID
- BARABINO, GILDA A.
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 16
- Issue
- 1
- Pages
- 97-111
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- PMC
- PMC3059190
- OpenAlex
- W2067770510
- Cited by
- 208
- References
- 85
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 9 · 2020: 20 · 2019: 15 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 16 · 2013: 12 · 2012: 6
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (U54 070994)
- National Heart, Lung, and Blood Institute (HL071631, R01HL070047, K25HL071631)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- sickle cell disease, endothelium, vascular occlusion, ligand-receptor interactions, adhesion molecules, leukocyte recruitment, endothelial activation, anti-adhesion therapy
- MeSH terms
- Anemia, Sickle Cell, Animals, Cell Adhesion, Cell Communication, Endothelium, Vascular, Erythrocytes, Abnormal, Humans, Leukocytes, Mice, Transgenic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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