Cited by 208Hemoglobinopathies and Related DisordersBlood properties and coagulationCell Adhesion Molecules Research

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Sickle Red Cell–Endothelium Interactions

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KAUL, DHANANJAY K., FINNEGAN, EILEEN, BARABINO, GILDA A.·2009·Microcirculation

DOI 10.1080/10739680802279394PMC PMC3059190

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Abstract

Periodic recurrence of painful vaso‐occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell–endothelium interaction has been implicated as a potential initiating mechanism in vaso‐occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and microcirculatory findings on sickle red cell adhesion, its potential role in vaso‐occlusion, and the current understanding of receptor‐ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte–red cell interaction) to vaso‐occlusion, as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.

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Identification of the platelet ADP receptor targeted by antithrombotic drugs
Hollopeter, G., Jantzen, H., Vincent, D., Li, G., England, L. J., Ramakrishnan, V., Yang, R., Nurden, P., Nurden, A. T., Julius, D. J., et al. (2001) · Nature · doi:10.1038/35051599 · Cited by 1,421
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., et al. (2002) · Nature Medicine · doi:10.1038/nm799 · Cited by 1,097
Sickle-cell disease
Stuart, M. J., & Nagel, R. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17192-4 · Cited by 867
Circulating Activated Endothelial Cells in Sickle Cell Anemia
Solovey, A. N., Lin, Y., Browne, P., Choong, S., Wayner, E. A., & Hebbel, R. P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372203 · Cited by 626
Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.
Pfaff, M., Tangemann, K., Müller, B., Gurrath, M., Müller, G., Kessler, H., Timpl, R., & Engel, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31981-6 · Cited by 535
Erythrocyte Adherence to Endothelium in Sickle-Cell Anemia
Hebbel, R. P., Boogaerts, M., Eaton, J. W., & Steinberg, M. H. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005013021803 · Cited by 518
Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
Turhan, A., Weiss, L. A., Mohandas, N., Coller, B. S., & Frenette, P. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052522799 · Cited by 487
The Endothelial Biology of Sickle Cell Disease: Inflammation and a Chronic Vasculopathy
Hebbel, R. P., Osarogiagbon, R. U., & Kaul, D. K. (2004) · Microcirculation · doi:10.1080/10739680490278402 · Cited by 464
Self-citation
Spontaneous oxygen radical generation by sickle erythrocytes.
Hebbel, R. P., Eaton, J. W., Balasingam, M., & Steinberg, M. H. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110724 · Cited by 444

Show all 85 references

Research works printed but not linked: 3

10.1172/JCI200421633 · DOI
Kaul DK, 1995, Sickle Cell Disease and Thalassemias: New Trends in Therapy (INSERM Symposium), 497
10.1182/blood.V80.10.2634.2634 · DOI

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Authors: KAUL, D. K., FINNEGAN, E., & BARABINO, G. A.
Affiliations: Albert Einstein College of Medicine (US)
Georgia Institute of Technology (US)
Corresponding author: KAUL, DHANANJAY K.
ORCID: BARABINO, GILDA A.
Venue: Microcirculation
Publisher: Wiley
Published: 2009-01
Volume: 16
Issue: 1
Pages: 97-111
ISSN: 1073-9688 (ISSN-L)
1549-8719
DOI: 10.1080/10739680802279394
PMC: PMC3059190
OpenAlex: W2067770510
Cited by: 208
References: 85
Citations by year: 2026: 5 · 2025: 11 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 9 · 2020: 20 · 2019: 15 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 16 · 2013: 12 · 2012: 6
FWCI: 0.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 390 d)
Locations: Microcirculation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (U54 070994)
National Heart, Lung, and Blood Institute (HL071631, R01HL070047, K25HL071631)
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: sickle cell disease, endothelium, vascular occlusion, ligand-receptor interactions, adhesion molecules, leukocyte recruitment, endothelial activation, anti-adhesion therapy
MeSH terms: Anemia, Sickle Cell, Animals, Cell Adhesion, Cell Communication, Endothelium, Vascular, Erythrocytes, Abnormal, Humans, Leukocytes, Mice, Transgenic, Mice

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