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Sickle Red Cell–Endothelium Interactions
Open accessAbstract
Periodic recurrence of painful vaso‐occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell–endothelium interaction has been implicated as a potential initiating mechanism in vaso‐occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and microcirculatory findings on sickle red cell adhesion, its potential role in vaso‐occlusion, and the current understanding of receptor‐ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte–red cell interaction) to vaso‐occlusion, as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.
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“Importantly, sickling-dependent damage of erythrocyte membranes also promotes exposure of adhesion molecules and binding motifs not normally expressed on erythrocytes, such as phosphatidyl serine (PS), basal cell adhesion molecule-1/Lutheran (B-CAM-1/Lu), integrin-associated protein (IAP), and intercellular-adhesion-molecule-4 (ICAM-4) (7, 9, 15).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [15]
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Metadata
- Authors
- KAUL, D. K., FINNEGAN, E., & BARABINO, G. A.
- Affiliations
- Albert Einstein College of Medicine (US)
- Georgia Institute of Technology (US)
- Corresponding author
- KAUL, DHANANJAY K.
- ORCID
- BARABINO, GILDA A.
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 16
- Issue
- 1
- Pages
- 97-111
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- PMC
- PMC3059190
- OpenAlex
- W2067770510
- Cited by
- 208
- References
- 85
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 9 · 2020: 20 · 2019: 15 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 16 · 2013: 12 · 2012: 6
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (U54 070994)
- National Heart, Lung, and Blood Institute (HL071631, R01HL070047, K25HL071631)
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- sickle cell disease, endothelium, vascular occlusion, ligand-receptor interactions, adhesion molecules, leukocyte recruitment, endothelial activation, anti-adhesion therapy
- MeSH terms
- Anemia, Sickle Cell, Animals, Cell Adhesion, Cell Communication, Endothelium, Vascular, Erythrocytes, Abnormal, Humans, Leukocytes, Mice, Transgenic, Mice
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