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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
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Note: This article was originally published with an incorrect version of the Acknowledgments, which appeared on p. 218 of the print version. The correct version of the Acknowledgments appeared on pp. 1–2. The corrected article is available below.
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“The total body burden of Al in healthy humans has been reported to be approximately 30–50 mg/kg body weight and normal levels of Al in serum are approximately 1–3μg/L (Krewski et al., 2007).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Krewski et al., 2007
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“Al levels increase with age in tissues and organs (bone, muscle, lung, liver, and kidney) of experimental animals (Krewski et al., 2007).”
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“The Al ion in blood circulation is eliminated primarily by the kidneys (about 95%) in the urine, presumably as Al citrate (Shirley and Lote, 2005; Krewski et al., 2007; Anon, 2008c).”
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“Moreover, Al has been shown to rapidly enter the brain, extracellular fluid and the cerebrospinal fluid, with smaller concentrations in these organs than in the blood (Martin, 1992; Krewski et al., 2007).”
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Metadata
- Authors
- Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V.
- Affiliations
- University of Ottawa (CA)
- University of Kentucky (US)
- UiT The Arctic University of Norway (NO)
- University of Florida (US)
- Tufts Medical Center (US)
- National Institutes of Health (US)
- Public Health Agency of Canada (CA)
- Environmental Protection Agency (US)
- Inserm (FR)
- Corresponding author
- Krewski, Daniel
- Venue
- Journal of Toxicology and Environmental Health, Part B
- Publisher
- Informa UK Limited
- Published
- 2007-11-16
- Volume
- 10
- Issue
- sup1
- Pages
- 1-269
- ISSN
- 1093-7404 (ISSN-L)
- 1521-6950
- PMC
- PMC2782734
- OpenAlex
- W2100043100
- Cited by
- 998
- References
- 1,426
- Citations by year
- 2026: 29 · 2025: 54 · 2024: 61 · 2023: 89 · 2022: 71 · 2021: 98 · 2020: 109 · 2019: 92 · 2018: 79 · 2017: 58 · 2016: 57 · 2015: 42 · 2014: 44 · 2013: 30 · 2012: 27
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Toxicology and Environmental Health Part B (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- National Institutes of Health (Z99-ES999999)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- aluminum, alumina, aluminum hydroxide, human health risk assessment, aluminum toxicity
- MeSH terms
- Aluminum, Aluminum Hydroxide, Aluminum Oxide, Animals, Environmental Exposure, Humans, Tissue Distribution, Occupational Exposure, Aluminum Compounds, Risk Assessment, Toxicity Tests
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