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Gastrointestinal absorption, tissue retention, and urinary excretion of dietary aluminum in rats determined by using 26Al
Abstract
We used accelerator mass spectrometry (AMS) and 26AI to study the plasma concentration, urinary excretion, and retention in bone, brain, and liver of a single dose of a dietary concentration of aluminum ingested either with or without citrate by 2-month-old Wistar rats. In the absence of citrate, cumulative urinary excretion and skeleton retention were each approximately 0.05% of the total 26AI dose ingested. 26AI retention in brain and liver were approximately 4 x 10(-8) and 2 x 10(-6), respectively. Concomitant citrate intake increased these median values by about two- to fivefold, although this factor was highly variable in individual rats. Independent of citrate administration, 90% of the 26AI excreted in urine (measured cumulatively over 30 days) was excreted within the first 48 h. Uptake by bone was rapid (approximately 1 h) and permanent over the 30-day duration of the experiment.
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“Inhalation and ingestion (via food and water) are the two main routes through which Al gets into the body (Alfrey, 1980; Teraoka, 1981; Jouhanneau et al., 1997).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Jouhanneau et al., 1997
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Cited by
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Inhalation and ingestion (via food and water) are the two main routes through which Al gets into the body (Alfrey, 1980; Teraoka, 1981; Jouhanneau et al., 1997).”
Background
Metadata
- Authors
- Jouhanneau, P., Raisbeck, G. M., Yiou, F., Lacour, B., Banide, H., & Drüeke, T. B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), CNRS-IN2P3, Bat 108, 91405 Orsay, France
- Hôpital Necker-Enfants Malades (FR)
- Département de Physiologie, Faculté de Pharmacie, Châtenay-Malabry, France
- INSERM U 90, Hôpital Necker, Paris, France
- Corresponding author
- Raisbeck, Grant M
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-06-01
- Volume
- 43
- Issue
- 6
- Pages
- 1023-1028
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2102659734
- Cited by
- 65
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- dietary aluminum, 26Al, gastrointestinal absorption, tissue retention, urinary excretion, citrate, bone preservation, brain, liver, plasma concentration, aluminum toxicity, rats
- MeSH terms
- Albumins, Albuminuria, Animals, Brain, Diet, Intestinal Absorption, Liver, Male, Radioisotopes, Serum Albumin, Mass Spectrometry, Time Factors, Tissue Distribution, Rats, Wistar, Rats
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