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Exploring bioactive fraction of Sargassum wightii: In vitro elucidation of angiotensin-I-converting enzyme inhibition and antioxidant potential
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Bioactive fraction of brown algae Sargassum wightii (SWE) was obtained using silica column chromatography and preparative Thin Layer Chromatography (TLC). FT-IR and LC–mass spectrometry ESI analysis revealed presence of various phlorotannins in the SWE. The IC50 value of SWE was found to be 59.91, 51.04, and 55.21 μg/ml for scavenging of 2,2-diphenyl-1-picrylhydrazyl, 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), and Ferric Reducing Antioxidant Power assay, respectively. SWE inhibited angiotensin-I-converting enzyme (ACE) in mixed-type manner with IC50 value of 56.96 µg/ml and Ki value of 45 µg/ml. The dual function such as antioxidant and ACE inhibition of SWE warrants further study to understand the antihypertensive potential in vivo.
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Metadata
- Authors
- Vijayan, R., Chitra, L., Penislusshiyan, S., & Palvannan, T.
- Affiliations
- Department of Biochemistry, Periyar University
- Periyar University (IN)
- Corresponding author
- Palvannan, Thayumanavan
- Venue
- International Journal of Food Properties
- Publisher
- Informa UK Limited
- Published
- 2018-01
- Volume
- 21
- Issue
- 1
- Pages
- 674-684
- ISSN
- 1094-2912 (ISSN-L)
- 1532-2386
- OpenAlex
- W2802260184
- Cited by
- 37
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Food Properties (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University Grants Commission (RGNF-2015-17-SC-TAM-20532)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Sargassum wightii, brown algae, phlorotannins, angiotensin-converting enzyme inhibition, antioxidant activity, bioactive fractions, mixed-type inhibition, DPPH radical scavenging, ABTS radical scavenging, FRAP, marine natural products
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