Cited by 37Seaweed-derived Bioactive CompoundsProtein Hydrolysis and Bioactive PeptidesMedicinal Plant Research

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Exploring bioactive fraction of Sargassum wightii: In vitro elucidation of angiotensin-I-converting enzyme inhibition and antioxidant potential

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Vijayan, Raji, Chitra, Loganathan, Penislusshiyan, Sakayanathan, Palvannan, Thayumanavan·2018·International Journal of Food Properties

Abstract

Bioactive fraction of brown algae Sargassum wightii (SWE) was obtained using silica column chromatography and preparative Thin Layer Chromatography (TLC). FT-IR and LC–mass spectrometry ESI analysis revealed presence of various phlorotannins in the SWE. The IC50 value of SWE was found to be 59.91, 51.04, and 55.21 μg/ml for scavenging of 2,2-diphenyl-1-picrylhydrazyl, 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), and Ferric Reducing Antioxidant Power assay, respectively. SWE inhibited angiotensin-I-converting enzyme (ACE) in mixed-type manner with IC50 value of 56.96 µg/ml and Ki value of 45 µg/ml. The dual function such as antioxidant and ACE inhibition of SWE warrants further study to understand the antihypertensive potential in vivo.

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Crossref · 10.1080/10942912.2018.1454465

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  1. 10.1111/fis.2006.72.issue-6 · DOI

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Metadata

Authors
Vijayan, R., Chitra, L., Penislusshiyan, S., & Palvannan, T.
Affiliations
  • Department of Biochemistry, Periyar University
  • Periyar University (IN)
Corresponding author
Palvannan, Thayumanavan
Venue
International Journal of Food Properties
Published
2018-01
Volume
21
Issue
1
Pages
674-684
ISSN
  • 1094-2912 (ISSN-L)
  • 1532-2386
OpenAlex
W2802260184
Cited by
37
References
36
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3
FWCI
3.01
Type
journal article
Language
en
Open access
Locations
  • International Journal of Food Properties (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University Grants Commission (RGNF-2015-17-SC-TAM-20532)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Sargassum wightii, brown algae, phlorotannins, angiotensin-converting enzyme inhibition, antioxidant activity, bioactive fractions, mixed-type inhibition, DPPH radical scavenging, ABTS radical scavenging, FRAP, marine natural products

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