The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015
Open accessAbstract
INTRODUCTION: There are dozens of drugs in development for AD with billions of dollars invested. Despite the massive investment in AD drugs and a burgeoning pipeline, there have been more setbacks and failures than treatment successes. Areas covered: The classes of drugs that have failed to date include the monoclonal antibodies, the gamma secretase inhibitors, dimebon, neurochemical enhancers, and one tau drug. Data for these compounds were sought through a PubMed search and a clinicaltrials.gov search. Expert opinion: The obvious question to be posed is: Why are they failing? Is the treatment of symptomatic dementia too late? Are the therapeutic targets incorrect? Are the clinical methodologies imprecise, misleading, or inaccurate? This review summarizes the drugs that have failed during 2010-2015 and offers possible theories as to why they have failed.
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Cites
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Self-citationPhase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
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A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease
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Cited by
Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044
Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
Baker, D. J., & Petersen, R. C. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95145 · Cited by 514
Synaptic degeneration in Alzheimer disease
Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504
Nativio, R., Lan, Y., Donahue, G., Sidoli, S., Berson, A., Srinivasan, A. R., Shcherbakova, O., Amlie-Wolf, A., Nie, J., Cui, X., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0696-0 · Cited by 380
Amyloid Beta in Aging and Alzheimer’s Disease
Sehar, U., Rawat, P., Reddy, A. P., Kopel, J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112924 · Cited by 361
Metadata
- Authors
- Mehta, D., Jackson, R., Paul, G., Shi, J., & Sabbagh, M.
- Venue
- Expert Opinion on Investigational Drugs
- Publisher
- Informa UK Limited
- Published
- 2017-05-02
- Volume
- 26
- Issue
- 6
- Pages
- 735-739
- ISSN
- 1354-3784 (ISSN-L)
- 1744-7658
- OpenAlex
- W2610795807
- Cited by
- 607
- References
- 25
- FWCI
- 37.25
- Type
- journal article
- Language
- en
- Open access
- green
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