Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery
Open accessAbstract
Objective: We assessed the effect on lower urinary tract symptoms (LUTS) of a supplement containing cranberry, D-mannose and anti-inflammatory molecules in postmenopausal women undergoing surgery for cystocele.Study design: Forty postmenopausal women were randomized 1:1 to an active group receiving the nutritional supplement twice a day for 2 weeks starting from surgery, or to a control group receiving surgery only. Primary outcomes were the effectiveness in the postoperative LUTS and urinary tract infections (UTI). LUTS were investigated by a validated questionnaire (ICIQ-FLUTS) at baseline and at week 4. Secondary outcomes were the safety and tolerability of the supplement and other perioperative outcomes.Results: No significant differences were found in perioperative outcomes and in incidence of UTI. After surgery, women treated with the supplement experienced significantly better scores on the filling domain of the questionnaire. A non-significant decrease in voiding scores was also found. No adverse events were detected.Conclusion: The use of an oral supplement containing cranberry, D-mannose and anti-inflammatory molecules decreases the perception of LUTS in postmenopausal women after anterior colporraphy. Our data suggest that perioperative use of nutritional supplements may be useful in the management of postoperative LUTS.
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Perioperative interventions in pelvic organ prolapse surgery
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- Authors
- Russo, E., Montt Guevara, M., Giannini, A., Mannella, P., Palla, G., Caretto, M., Pancetti, F., Genazzani, A. D., & Simoncini, T.
- Affiliations
- University of Pisa (IT)
- Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Simoncini, T.
- Venue
- Climacteric
- Publisher
- Informa UK Limited
- Published
- 2019-11-01
- Volume
- 23
- Issue
- 2
- Pages
- 201-205
- ISSN
- 1369-7137 (ISSN-L)
- 1473-0804
- OpenAlex
- W2987083102
- Cited by
- 17
- References
- 28
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- Climacteric (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- cranberry, D-mannose, anti-inflammatory agents, lower urinary tract symptoms, cystocele, anterior colporrhaphy, postmenopausal women, urinary tract infection, dietary supplements, perioperative supplementation, voiding dysfunction, postoperative symptoms
- MeSH terms
- Aged, Anti-Inflammatory Agents, Drug Therapy, Combination, Female, Humans, Mannose, Postoperative Complications, Preoperative Care, Prospective Studies, Vaccinium macrocarpon, Pelvic Organ Prolapse, Lower Urinary Tract Symptoms
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